London: British researchers have identified a key protein that can control how breast cancer cells spread in the body.
The study sheds light on how cancer cells leave the blood vessels to travel to a new part of the body, said the researchers from the University of Manchester in Britain.
When tumor cells spread, they first enter the blood stream and grip onto the inner walls of blood vessels, the researchers elicited.
The cancer cells control a receptor protein called EPHA2 in order to push their way out of the vessels, they added.
When these cancer cells interact with the walls of the blood vessels, EPHA2 is activated and the tumor cells remain inside the blood vessels. When the EPHA2 is inactive, the tumor cells can push out and spread, revealed the study published in the journal Science Signaling.
The researchers used a technique that allowed them to map how cancer cells interact and exchange information with cells that make up the blood vessels.
“The next step is to figure out how to keep this receptor switched on, so that the tumor cells can’t leave the blood vessels – stopping breast cancer spreading and making the disease easier to treat successfully,” concluded the lead researcher Claus Jorgensen from the University of Manchester. (IANS)
New York, Nov 19: Researchers have discovered a new protein that could reduce the spread of cancer by binding the cancer cells together and allowing them to invade tissues.
The study conducted by the researchers from University of Guelph, Ontario, has identified a protein called cadherin-22, a potential factor in cancer metastasis or the spread of cancer.
The protien also decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.
“Cadherin-22 could be a powerful prognostic marker for advanced cancer stages and patient outcomes,” said lead author Jim Uniacke, a professor at the varsity.
“If you can find a treatment or a drug that can block cadherin-22, you could potentially prevent cancer cells from moving, invading and metastasizing.”
The study, published in the journal Oncogene, looks specifically at hypoxia, a condition in which the tissues receive less oxygen.
The researchers found that it is precisely under conditions of low oxygen that cancer cells trigger the production of cadherin-22, putting in motion a kind of protein boost that helps bind cells together, enhancing cellular movement, invasion and likely metastasis.
Studying breast and brain cancer cells in a hypoxia incubator, the researchers discovered that cadherin-22 is involved in this process to enable the spread of cancer cells.
For both cancer types, the research team used molecular tools to reduce the amount of cadherin-22.
They placed the human cancer cells into the incubator and lowered the oxygen to a level comparable to that in a tumour. The cells failed to spread.
“One very powerful and common tool in cell and molecular biology labs is, you can remove a protein from a cell and see how that cell behaves without it.
“We culture our cancer cells in this very low-oxygen environment, and they start behaving like they are inside a low-oxygen tumour,” Uniacke added. (IANS)
New York, Nov 5: Undergoing a type of hormone replacement therapy — used for menopausal treatment — may help protect as well as improve working memory for some women as they age, according to a new study.
Hormone replacement therapy uses female hormones – oestrogen and progesterone – to treat common symptoms of menopause and ageing.
The findings showed that women taking oestrogen-only therapy had lower levels of the stress hormone cortisol and performed better on tests of “working memory” following exposure to stress compared to women taking a placebo.
“Our study suggests that oestrogen treatment after menopause protects the memory that is needed for short-term cognitive tasks from the effects of stress,” said lead author Alexandra Ycaza Herrera, a researcher at the University of Southern California – Davis.
To measure the effect of oestrogen therapy on working memory under stress, the team recruited 42 women with an average age of 66.
Half of the postmenopausal women had been on estradiol — a type of oestrogen therapy — for approximately five years, while the others had received a placebo.
The researchers, in the paper published in the Journal of Clinical Endocrinology and Metabolism, collected saliva to measure the women’s levels of cortisol, oestrogen, and progesterone.
They also ran a test of working memory called a “sentence span task”, in which the women were each given a series and then asked whether each sentence made sense. They also were asked to recall the last word of each one.
While women receiving oestrogen therapy had a smaller increase in cortisol and showed no decrease in working memory function, even after being exposed to stressful situation, those taking the placebo experienced a spike in cortisol levels as well as demonstrated a decrease in working memory function.
Previous studies have pointed to potential health risks — the Ahigher risk of breast cancer, heart disease, stroke and blood clots — of the treatment.
Thus, Herrera noted that “hormone replacement therapy may not be right for every woman, but women need to be able to have the conversation with their doctors”.(IANS)
New Delhi, Oct 7, 2017: Breast Cancer is one of the supreme causes of female deaths, however, it’s awareness is low in India. A leading Radiologist, Dr. Jyoti Arora, Associate Director, Medanta – the Medicity states that 8 out of 10 cases of breast lumps are not cancerous and undergoing biopsy is the only way to rule out breast cancer.
In India, two responses with respect to breast lumps are generally normal. Either the feeling of a lump formation in the breast is disregarded or the patient gets hysterical. The two responses are extreme and caused by the absence of proper awareness but in altogether different ways.
A recent study summarized that its predominance is as high as 25.8 per 1,00,000 women and its death rate are 12.7 per 1,00,000 women, mentioned ANI.
Dr. Arora has disclosed that because of the absence of awareness, a huge number of Indian women do not choose appropriate tests and treatment.
Arora said, “One of the first symptoms of breast cancer is the formation of lumps in the breast. While many women from not so educated and aware sections of society do not identify lump in the breast as a reason enough to see the doctor, those who are aware of the connection between breast lumps and cancer does not realize that in 8 out of 10 cases, lumps in breasts are non-cancerous. For them, a breast lump is the synonym of breast cancer and they feel it’s the end of their life so do not get it evaluated.”
As the lumps are associated with pain, some females do not seek medical advice. The non-cancerous lumps are cyst formation, fibro-adenoma which is an abnormal non-cancerous growth, or maybe a temporary sign due to woman’s menstrual cycle.
Cancerous lumps are usually hard to feel and not associated with pain.
So if a female feels a lump, she should visit a breast specialist who will get a mammography and ultrasound done. If a solid lump is confirmed on imaging then in most of the cases biopsy would be needed to confirm whether the lump is cancerous or not.
To check cancerous cells, a radiologist removes tissue while conducting a breast biopsy from the suspected area for lab testing.
“There are various types of biopsies that a patient is offered. Tru cut needle biopsy is performed in majority of the cases, however when the abnormality is very small, subtle or when seen only on the mammograms in the form of calcifications or only on the breast MRI, vacuum-assisted breast biopsies (VABB) are preferred as they increase the accuracy and sensitivity of getting a representative sample from the abnormal area. Through VABB, more tissue can be removed than by the true cut needle biopsy and hence a more accurate report can be generated by the pathologist,” added Arora.
One should look for changes in the breast in terms of size and shape. Other than formation of lump, observe whether there are skin changes such as swelling and redness, in drawing of the nipples or if there is pain, irritation, change of color, or peeling and flaking of nipple skin.