Saturday October 21, 2017

Combination of Drugs for Diabetes and Hypertension may offer an effective new way to combat Cancer

the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed "suicide".

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Suicide for cancer cells via a combination drug
A combination drug of diabeties and hypertension to cure cancer,pixabay

London, December 28, 2016: A combination of drugs for diabetes and hypertension may offer an effective new way to combat cancer, suggests a new research.

In their experiments, the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed “suicide”.

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 “We have been able to show that the two known drugs lead to more profound effects on cancer cell proliferation than each drug alone,” said study first author Don Benjamin from the University of Basel in Switzerland.

“The data from this study support the development of combination approaches for the treatment of cancer patients,” Benjamin noted.

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Metformin is a widely prescribed drug for the treatment of Type-2 diabetes.

Besides its blood sugar lowering effect, it also displays anti-cancer properties. The usual therapeutic dose, however, is too low to effectively fight cancer.

At higher doses, the antidiabetic drug inhibits the growth of cancer cells but could also induce unwanted side effects.

The new research published in the journal Science Advances showed that the antihypertensive drug syrosingopine enhances the anti-cancer efficacy of metformin.

The study showed the cocktail of these two drugs is effective in a wide range of cancers.

“For example, in samples from leukemia patients, we demonstrated that almost all tumour cells were killed by this cocktail and at doses that are actually not toxic to normal cells”, Benjamin said.

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“And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment,” Benjamin noted.

In mice with malignant liver cancer, enlargement of the liver was reduced after the therapy. Also the number of tumor nodules was less — in some animals the tumours disappeared completely.

The researchers found that the drugs interrupt the vital processes which provide energy for the cancer cell. (IANS)

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Prostate cancer, the second most common cause of cancer rises in rural India, according to experts

The rural masses need to be made aware of the treatment, drugs and technologies to combat the disease

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Prostate cancer
Sarcomatoid prostate carcinoma, abbreviated SPC. Wikimedia
  • Prostate cancer is the sixth leading cause of cancer deaths among men worldwide
  • Experts claim, that the second most common cause of cancer, is rising in rural India 
  • The rural masses need to be made aware of the treatment, drugs and technologies to combat the disease.

New Delhi, September 22, 2017: Prostate cancer, the second most common cause of cancer and the sixth leading cause of cancer deaths among men worldwide, is rising in rural India, experts claim.

Cancer projection data shows that the number of cases will be doubled by 2020.

“Most of the metastatic prostate cancer cases are from rural areas. Therefore, it’s a challenge to government and doctors to decrease the risk factors and take prostate cancer risk in the rural areas very seriously,” P.N. Dogra, Professor and Head of Urology at AIIMS, said in a statement on Thursday.

The rural masses need to be made aware of the treatment, drugs and technologies to combat the disease.

“There is an urgent need to create awareness about prostate cancer threat amongst the rural population,” said Anup Kumar, Head (Department of Urology and Renal Transplant) at Safdarjung Hospital.

Also read: Abdominal fat drives cancer in postmenopausal women: Study

Safdarjung Hospital sees more than one lakh patients every month from all over the country.

Of these, 20 per cent are prostate cancer patients, in which 40 per cent are clinically localised, 30 per cent are locally advanced and 30 per cent are metastatic prostate cancer cases, Kumar said.

“Prostate cancer has become a major health problem globally during the last few decades. This disease is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide,” Dogra said.

According to the Population Based Cancer Registries in Delhi, the disease is the second most frequently diagnosed cancer among men in the national capital, accounting for about 6.78 per cent of all malignancies. (IANS)

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Tomato a day, Keeps Doctors Away ! 7 Health Benefits of Tomatoes

Here are some interesting health benefits of tomatoes

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Health benefits of tomatoes
Health benefits of tomatoes. Pixabay

Sep 21, 2017: Tomatoes are loaded with nutrition and oxidants that help to keep you salubrious and your wellbeing fit as a fiddle. The numerous health benefits of tomatoes can be credited to their abundance of nutrition values and vitamins, including vitamin A, vitamin C, and vitamin K, and vitamin B6, folate, and thiamin.

Tomato is taken as both, a vegetable and fruit and is an essential part of cooking all over the globe, particularly in the Mediterranean locale. If you consume tomatoes daily, it tends to lift your lifestyle. You may find them in incalculable diverse sustenances, including pastas, pizzas, ketchup, different refreshments, and as an included flavor component in dishes from breakfast to supper.

Here are some interesting health benefits of tomatoes

Enhances vision

Vitamin A in tomatoes enhances your vision and also forestall night-visual deficiency and macular degeneration.

Keeping up blood wellbeing

Tomato contains vitamin A, potassium, and iron that is fundamental for keeping up ordinary blood wellbeing.

Health benefits of tomatoes

Decreases danger of heart disease

The lycopene in tomatoes can secure you against cardiovascular diseases. Expending tomatoes frequently helps diminish the levels of cholesterol and triglyceride in the blood, lessening the deposition of fats in the veins.

Also Read: Eat According to Your Blood Type and See the Benefits Yourself! 

Useful for digestion

Eating tomatoes on a regular basis can keep your digestion sound as it avoids constipation as well as and loose bowels.

Health benefits of tomatoes

Reduces hypertension

Tomato reduces hypertension, ie the ‘high blood pressure’. This is due to the potassium found in tomatoes. Potassium reduces the tightness in blood vessels, thus enhances the flow and lowers the stress on the heart.

Skin care

Tomatoes help in maintaining healthy bones, teeth, skin, and hair. Limited application of tomato juice can also cure severe sunburns. They are also dominant in fighting the skin aging.

Health benefits of tomatoes

Stops urinary tract infection

Tomato consumption also diminishes the frequency of urinary tract infections as they have relatively more water content that stimulates urination. It also eliminates toxins, salts, excess water, uric acid from the body.


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Percentage of US College Students Using Marijuana at the Highest Level in 30 Years, Claims New Study

The increasing use of marijuana among college students deserves immediate attention from college personnel as well as students and their parents

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Marijuana
Marijuana grower and activist Juan Vaz checks marijuana plants in Montevideo, Uruguay, VOA

Washington, September 12, 2017 : Percentage of US college students using marijuana was at the highest level in 2016 since the past three decades, according to a study conducted by University of Michigan researchers.

The national Monitoring the Future follow-up study, funded by the the National Institute on Drug Abuse, showed in 2016, 39 per cent of full-time college students aged 19-22 indicated that they used marijuana at least once in 12 months, and 22 per cent indicated that they used at least once in 30 days, reports Xinhua news agency.

ALSO READ Substance abuse of Marijuana rises in the United States

Both of these 2016 percentages were the highest since 1987, and represented a steady increase since 2006, when they were 30 and 17 per cent, respectively.

Daily or near daily use of marijuana-defined as having used 20 or more times in the prior 30 days-was at 4.9 per cent in 2016; this is among the highest levels seen in more than 30 years, though it has not shown any further rise in the past two years.

“These continuing increases in marijuana use, particularly heavy use, among the nation’s college students deserve attention from college personnel as well as students and their parents,” John Schulenberg, the current principal investigator of the Monitoring the Future follow-up study, said on Monday.

“We know from our research and that of others that heavy marijuana use is associated with poor academic performance and non-completion of college.

In 2016, 30 per cent of those aged 19-22 perceived regular use of marijuana as carrying great risk of harm, the lowest level reached since 1980.

These findings come from the long term Monitoring the Future study, which has been tracking substance use of all kinds among American college students for the past 37 years. (IANS)