Tuesday July 23, 2019

Combination of Drugs for Diabetes and Hypertension may offer an effective new way to combat Cancer

the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed "suicide".

1
//
Suicide for cancer cells via a combination drug
A combination drug of diabeties and hypertension to cure cancer,pixabay

London, December 28, 2016: A combination of drugs for diabetes and hypertension may offer an effective new way to combat cancer, suggests a new research.

In their experiments, the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed “suicide”.

NewsGram brings to you current foreign news from all over the world.

 “We have been able to show that the two known drugs lead to more profound effects on cancer cell proliferation than each drug alone,” said study first author Don Benjamin from the University of Basel in Switzerland.

“The data from this study support the development of combination approaches for the treatment of cancer patients,” Benjamin noted.

NewsGram brings to you top news around the world today.

Metformin is a widely prescribed drug for the treatment of Type-2 diabetes.

Besides its blood sugar lowering effect, it also displays anti-cancer properties. The usual therapeutic dose, however, is too low to effectively fight cancer.

At higher doses, the antidiabetic drug inhibits the growth of cancer cells but could also induce unwanted side effects.

The new research published in the journal Science Advances showed that the antihypertensive drug syrosingopine enhances the anti-cancer efficacy of metformin.

The study showed the cocktail of these two drugs is effective in a wide range of cancers.

“For example, in samples from leukemia patients, we demonstrated that almost all tumour cells were killed by this cocktail and at doses that are actually not toxic to normal cells”, Benjamin said.

Check out NewsGram for latest international news updates.

“And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment,” Benjamin noted.

In mice with malignant liver cancer, enlargement of the liver was reduced after the therapy. Also the number of tumor nodules was less — in some animals the tumours disappeared completely.

The researchers found that the drugs interrupt the vital processes which provide energy for the cancer cell. (IANS)

  • Ruth

    I don’t like drink cocktail.

Next Story

Suspending Students Serve as Negative Turning Point in Adolescence; Makes Them More Prone to Hold Guns, Sell Drugs

Mowen and colleagues studied to what extent being suspended from middle and high school was a turning point that led to more deviant behaviour

0
suspending students, drugs
Offending was defined as attacking or assaulting someone, possessing a gun, selling illegal substances, destroying property and stealing. Pixabay

Suspending students from school can do more harm than good, said researchers, suggesting that suspending students can serve as a negative and harmful turning point in adolescence, resulting in more crime like assaults, stealing and selling drugs in the neighbourhood.

The study by researchers at Bowling Green State University and Eastern Kentucky University and published in Justice Quarterly found that rather than decreasing subsequent offending, school suspensions increase such behaviour.

“Intensifying disciplinary strategies — what some have called the criminalization of school discipline — may do more harm than good and could result in more crime in schools, neighbourhoods and communities,” said Thomas James Mowen, assistant professor of sociology at Bowling Green State University.

Mowen and colleagues studied to what extent being suspended from middle and high school was a turning point that led to more deviant behaviour. They also examined whether school suspensions, the most common response to youth’s misbehaviour at school, amplified the likelihood that adolescents would offend as they grew into young adults.

suspending students, drugs
Powder drugs. Wikimedia Commons

Offending was defined as attacking or assaulting someone, possessing a gun, selling illegal substances, destroying property and stealing. The study found that exclusionary school discipline (suspensions) increased subsequent offending, substantially amplifying deviant behaviour as the youth moved through adolescence and into adulthood. Repeated suspensions further amplified subsequent offending.

ALSO READ: Pakistan, India to Allow Sikh Pilgrims Visa-Free Access to Gurudwara Darbar Sahib Kartarpur

The researchers took into account a variety of factors that influence offending behaviour, including whether youth dropped out of school, how youth felt about their schools (whether they felt safe, though their teachers were interested in them, believed school discipline was fair), how they felt about their families and their families’ income.

“The findings point to the need for school officials and policymakers to recognize the negative consequences of these approaches, examine the underlying causes of students’ behaviour and change how we manage that misbehaviour,” said Mowen. (IANS)