Monday January 21, 2019

Combination of Drugs for Diabetes and Hypertension may offer an effective new way to combat Cancer

the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed "suicide".

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Suicide for cancer cells via a combination drug
A combination drug of diabeties and hypertension to cure cancer,pixabay

London, December 28, 2016: A combination of drugs for diabetes and hypertension may offer an effective new way to combat cancer, suggests a new research.

In their experiments, the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed “suicide”.

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 “We have been able to show that the two known drugs lead to more profound effects on cancer cell proliferation than each drug alone,” said study first author Don Benjamin from the University of Basel in Switzerland.

“The data from this study support the development of combination approaches for the treatment of cancer patients,” Benjamin noted.

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Metformin is a widely prescribed drug for the treatment of Type-2 diabetes.

Besides its blood sugar lowering effect, it also displays anti-cancer properties. The usual therapeutic dose, however, is too low to effectively fight cancer.

At higher doses, the antidiabetic drug inhibits the growth of cancer cells but could also induce unwanted side effects.

The new research published in the journal Science Advances showed that the antihypertensive drug syrosingopine enhances the anti-cancer efficacy of metformin.

The study showed the cocktail of these two drugs is effective in a wide range of cancers.

“For example, in samples from leukemia patients, we demonstrated that almost all tumour cells were killed by this cocktail and at doses that are actually not toxic to normal cells”, Benjamin said.

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“And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment,” Benjamin noted.

In mice with malignant liver cancer, enlargement of the liver was reduced after the therapy. Also the number of tumor nodules was less — in some animals the tumours disappeared completely.

The researchers found that the drugs interrupt the vital processes which provide energy for the cancer cell. (IANS)

  • Ruth

    I don’t like drink cocktail.

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Over Three Lakh Drug Addicts Treated By Punjab Police in 2018

The action plan named Comprehensive Action against Drug Abuse is aimed at choking the supply of drugs through enforcement and reducing the demand through de-addiction and prevention.

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drugs
The action plan named Comprehensive Action against Drug Abuse is aimed at choking the supply of drug

Over three lakh drug addicts were treated in Punjab in 2018 and more than 63,000 people are currently being treated, out of which 25,000 are heroin addicts, a top police official said on Tuesday.

The retention rate is 91.71 per cent, Director General (Special Task Force) Mohammad Mustafa told reporters here.

The Special Task Force, constituted by the state in April 2017, has been implementing a three-pronged strategy of enforcement, de-addiction and prevention (EDP) to combat the menace of drugs.

The action plan named Comprehensive Action against Drug Abuse is aimed at choking the supply of drugs through enforcement and reducing the demand through de-addiction and prevention.

india-china trade
Generic drugs produced by Indian pharmaceutical companies make medicines affordable, but India says that China does not provide market access to its generic drugs. VOA

Mustafa said a multi-layered monitoring and implementing mechanism has been put in place. The Cabinet sub-committee on drugs headed by Chief Minister Amarinder Singh is monitoring it.

He said the outpatient treatment being rendered at 168 Outpatient Opioid Assisted Treatment Clinics is a great success.

To make students aware about the ill-effects of drugs, the Buddy Project has been implemented.

Approximately five lakh Drug Abuse Prevention Officers have been registered, 1,500 cluster coordinators and 15,000 Nasha Roku Nigran Committees are being trained through 523 master trainers.

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Over 3 lakh drug addicts treated in Punjab in 2018

Under this project, he said, 329 master trainers are training three lakh school teachers and college lecturers who will impart skills to approximately 40 lakh students.

He said 27 lakh students have already been covered.

A separate drug division is being set up in the Department of Health for efficient drug administration and better monitoring of de-addiction.

The Punjab Chief Minister in October 2018 sought a national drug policy to save the young generation, saying a comprehensive formula was needed at the central level to effectively check the drug abuse.

Punjab CM
Punjab CM Amarinder Singh

Earlier, six northern states unanimously decided to set up a common secretariat, to be based in Panchkula near Chandigarh, for data and information sharing, which was critical to the joint action.

Also Read: Here’s What Causes Cancer in Children

The states that have joined hands are Punjab, Haryana, Himachal Pradesh, Uttarakhand, Rajasthan and Delhi as also the Union Territory of Chandigarh.

The meeting accepted the suggestion of Amarinder Singh to hold regular meetings at various levels to tackle the problem and monitor the progress of the anti-drug fight. (IANS)