Friday April 20, 2018

Studies reveal that Depression might lower the chances of motherhood

Depression has been associated with dysregulation of the hypothalamic-pituitary-adrenal axis, which may influence the menstrual cycle and affect the ability to conceive.

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There is 38 percent decrease in the average probability of conception in a given menstrual cycle among women who reported severe depressive symptoms compared to the women who had no or low symptoms, finds out a recent study. It also revealed that the results were similar, regardless of whether the women were on psychotropic medications.

Despite associations in prior studies between infertility and the use of antidepressants, antipsychotics or mood stabilisers among already infertile women, “current use of psychotropic medications did not appear to harm the probability of conception,” said lead author Yael Nillni, an assistant professor at Boston University Schools of Public Health and Medicine in the US.

“Our findings suggest that moderate to severe depressive symptoms, regardless of current psychotropic medication treatment, may delay conception,” Nillni said. The findings were published in the American Journal of Obstetrics and Gynecology.

Although the study does not answer why women with more depressive symptoms may take longer to become pregnant, the authors noted several potential mechanisms.

Depression has been associated with dysregulation of the hypothalamic-pituitary-adrenal axis, which might influence the menstrual cycle and affect the ability to conceive.

Study collected data from around 2,100 female pregnancy planners, ages 21-45 years, enrolled in a study known as PRESTO (Pregnancy Study Online) is looking at the factors influencing fertility.

All women who participated were asked to report their current depressive symptoms and psychotropic medication use, among many other factors.(IANS)

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Study: Depression Can Be Cut by Ketamine

Ketamine, the drug can be helpful to cut off depression and suicidality

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A man in depression. Pixabay

Recreational drug Ketamine is likely to have fast-acting benefits in treating symptoms of depression as well as reducing suicidal thoughts, say researchers, including one of an Indian-origin.

The findings of the trial, published in the American Journal of Psychiatry, showed use of Ketamine, also licensed as an anaesthetic, through a nasal spray, led to significant improvements in depressive symptoms and reduction in suicidal thoughts in the first 24 hours.

A woman in depression.
A woman suffering from depression.

Esketamine could be an important treatment to bridge the gap as it can help in the rapid treatment compared to the delayed effects of most common antidepressants, which take four to six weeks to become fully effective, said Jaskaran B. Singh, from the Janssen Research & Development in San Diego, US.

The results support nasal spray esketamine as a possible effective rapid treatment for depressive symptoms in patients assessed to be at imminent risk for suicide, the researchers noted.

For the study, a small group of participants randomly assigned to one of two groups – either receiving esketamine or placebo twice a week for four weeks, and found a significant improvement in depression scores and decreased suicidal ideation in the esketamine group compared to the placebo group at four hours and at 24 hours.

Also Read: Depression Can Negatively Impact Heart Patients

However, at 25 days, the effects had levelled out.

While there esketamine dependence or misuse was not observed in the trial, the researchers suggested for effective controls on the distribution and use of ketamine.

They argued that steps to control the use of ketamine would not be aimed at preventing its use for beneficial purposes but would allow for treatment to “continue to be available to those with need, while the population that is at-risk for abuse is protected from an epidemic of misuse.”  IANS

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