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Gene showing opposite effect on some colorectal cancers

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New York: A gene that suppress the increase of many types of cancer is showing opposite effect in some forms of colorectal cancer, an Indian origin scientist said.

The research could lay the foundation for new colorectal cancer treatments.

“The gene is known as Sprouty2 has previously been shown to protect against metastasis, or the spreading of cancer to other parts of the body, in the breast, prostate and liver cancer,” said Sharad Khare, associate professor at University of Missouri School of Medicine in the US.

“However, our recent molecular studies found that this gene may actually help promote metastasis ( a spread of the disease to another organ) instead of suppressing it,” Khare noted.

For more than three years, Khare studied Sprouty2 in cancer cell models, mouse models and human biopsy samples.

Using different molecular methods, the researchers found that the gene functions differently in colorectal cancer than in other types of cancers.

Sprouty2 is known to block molecular circuits to prevent cancer cells from growing and spreading to other parts of the body.

However, the researchers found that in colorectal cancer, Sprouty2 may increase the ability of cancer cells to spread instead of suppressing it.

Khare believes this occurs when the gene is up-regulated or supercharged.

“This finding is a very significant step in our understanding of metastasis in colorectal cancer, but it’s important to note that we believe this phenomenon may occur in only a subset of colorectal cancer patients,” Khare said.

The findings appeared in the journal Oncogene.(IANS)(image:cellcan.com)

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  • Most bowel/colorectal cancers can be PREVENTED by removing pre-cancerous
    “polyps”. Google “Don’t get fined $35,000+ for missing a colonoscopy”.

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How Strength-based Exercise can keep you fit in a Long Run?

Some health benefits of doing strength-based exercise.

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Push ups is srength-based exercise.Pixabay
  • Do you want to stay fit and longer? Daily push-ups and sit-ups may add a few extra years to your lifespan, reveals new research.

Benefits of doing Strength-based Exercise

The research found that the people who did strength-based exercise had a 23 percent reduction in risk of premature death and a 31 percent reduction in cancer-related death.

“The study shows that strength-based exercise may be just as important for health as aerobic activities like jogging or cycling,” said Emmanuel Stamatakis, Associate Professor at the University of Sydney in Australia.

“And assuming our findings reflect cause and effect relationships, it may be even more vital when it comes to reducing the risk of death from cancer,” Stamatakis added.

The researchers observed 80,306 adults for two years and made some adjustments in order to reduce the influence of certain factors such as age, sex, health status, lifestyle behavior and educational level.

All participants with established cardiovascular disease or cancer at the baseline and those who passed away in the meanwhile were excluded from the study.

The research, published in the American Journal of Epidemiology, showed that exercises performed using one’s own body weight without specific equipment were just as effective as gym-based training.

“When people think of strength-based exercise, they instantly think of doing weights in a gym, but that doesn’t have to be the case,” noted Stamatakis.

“Many people are intimidated by gyms, the costs or the culture they promote, so it’s great to know that anyone can do classic exercises like triceps dips, sit-ups, push-ups or lunges in their own home or local park and potentially reap the same health benefits,” the researcher said. (IANS)

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Butterfly IQ : The iPhone-based Portable Ultrasound Machine to Detect Cancer

Developed by Connecticut-based start-up Butterfly Network, the pocket sized device works by shooting sound into the body and capturing the echoes.

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Butterfly IQ
There is a new portable device that might be able to detect cancer. Pixabay

New York, October 29, 2017 : A novel iPhone-based portable ultrasound machine that can help detect cancer easily at home has been developed by US researchers.

The device called Butterfly IQ is a scanner of the size of an electric razor that can display black-and-white imagery of the body, when paired with an iPhone.
Developed by Connecticut-based start-up Butterfly Network, the pocket sized device works by shooting sound into the body and capturing the echoes.
Usually, the sound waves are generated by a vibrating crystal. But Butterfly’s machine instead uses 9,000 tiny drums etched onto a semiconductor chip, reported the MIT Technology Review on Friday.
Earlier this year, John Martin, a US-based vascular surgeon and chief medical officer at Butterfly Network, discovered a cancerous mass in his own throat while testing the device.
Martin felt an uncomfortable feeling of thickness on his throat, thus he oozed out some gel and ran the probe along his neck.
On his smartphone, to which the device is connected, black-and gray images quickly appeared.
He found a 3 cm mass that was diagnosed as squamous-cell cancer — a form of skin cancer that develops in the cells of the outer layer of the skin.
Instead of vibrating crystals, Butterfly IQ uses “capacitive micro-machined ultrasound transducers”, or CMUTs, tiny ultrasonic emitters layered on a semiconductor chip a little larger than a postage stamp.
“The device gives you the ability to do everything at the bedside: you can pull it out of your pocket and scan the whole body,” Martin said.
The company now plans to combine the instrument with artificial-intelligence software that could help a novice position the probe, collect the right images, and interpret them.
By 2018, its software will let users automatically calculate how much blood a heart is pumping, or detect problems like aortic aneurisms, the report said.
The Butterfly IQ is the first solid-state ultrasound machine to reach the market in the US. The company plans to go on sale this year for $1,999-far less than any other model on the market. (IANS)

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Is their a link between sugar consumption and cancer? Scientists may finally be able to explain how tumors grow!

Previously, it was a topic of debate whether Warburg Effect was a symptom of cancer, or a cause of cancer.

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Can sugar contribute to growth of cancer in your body? Pixabay

Belgium, October 28, 2017: Is your sugar consumption causing, or spreading cancer in your body?

A new study published in the journal Nature Communications claims to have found the connection between sugar and cancer and scientists may finally be able to explain how tumors grow.

The nine-year-old study has revealed that cancer cells break down sugars at a faster rate than other cells which consequently stimulates the growth of tumors.

Scientists Study the Warburg Effect

Belgian scientists Veerle Janssens, Wim Versées and Johan Thevelein from VIB, KU Leuven, and Vrije Universiteit Brussel had first begun researching about sugar’s potential link to cancer in 2008 in an attempt to understand the Warburg Effect.

The Warburg Effect: First observed in 1924 by Otto Warburg, the Warburg Effect is a prominent feature of cancerous cells and if often put to use to detect brain tumors.

In simple terms, tumor cells make energy by rapidly breaking down proteins, which is not seen in normal cells. It is this energy that is fueling the growth of tumors.

The Study

For their research, scientists used yeast as a model organism as, like cancer cells, it employs a similar mechanism to produce energy from sugar- through fermentation.

Yeast also contains the ‘Ras’ proteins that are also found in cancer.

ALSO READ Sweet Tooth? Curb your Sugar Cravings with 7 Simple Steps!

Ras proteins are known to control the growth of cells in our body. If the genes that control Ras proteins mutate, they can cause an increased cell growth and an intensive production of cancer cells.

Thus, using yeast, the Belgian researchers analyzed the link between high sugar metabolism and Ras.

What Did The Study Reveal?

All cells in the body require sugar, but research has found that cancerous cells consume more sugar when compared to normal cells, breaking it down into glucose, which is then fermented into lactic acid. It is this fermentation that aids the spread of the tumor.

Previously, it was a topic of debate whether Warburg Effect was a symptom of cancer or a cause of cancer. The new study has revealed that it actually aids and stimulates cancerous tumors. However, this does not necessarily mean that sugar is causing cancer.

Explaining the “strength of the Warburg effect and tumor aggressiveness”, the study explains the consequences of the interaction of cancerous cells with sugar.

While these findings are monumental, scientists are not calling it a medical breakthrough. According to Prof. Johan Thevelein from KU Leuven in Belgium, the study will provide a foundation for future cancer research which will hopefully yield precise results.

– prepared by Soha Kala of NewsGram. Twitter @SohaKala