Wednesday December 13, 2017

Scientists discover new treatment for bone loss

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New York: Scientists from The Scripps Research Institute (TSRI), Florida, have developed a method to manipulate a protein that could result in the development of new bone-forming cells in patients suffering from bone loss.

The study, published in the journal Nature Communications, focused on a protein called PPARy (known as the master regulator of fat) and its impact on the fate of stem cells derived from bone marrow (mesenchymal stem cells).

Since these mesenchymal stem cells can develop into several different cell types — including fat, connective tissues, bone and cartilage — they have a number of potentially important therapeutic applications.

The scientists knew that a partial loss of PPARy in a genetically modified mouse model led to increased bone formation.

To see if they could mimic that effect using a drug candidate, the researchers designed a new compound that could repress the biological activity of PPARy.

The results showed that when human mesenchymal stem cells were treated with the new compound, which they called SR2595, there was a statistically significant increase in osteoblast formation, a cell type known to form bone.

“These findings demonstrate for the first time a new therapeutic application for drugs targeting PPARy, which has been the focus of efforts to develop insulin sensitisers to treat type 2 diabetes,” said Patrick Griffin, director of the Translational Research Institute at Scripps Florida.

“We have already demonstrated SR2595 has suitable properties for testing in mice. The next step is to perform an in-depth analysis of the drug’s efficacy in animal models of bone loss, ageing, obesity and diabetes,” Griffin added.

In addition to identifying a potential new therapeutic for bone loss, the study may have even broader implications.

“Because PPARG is so closely related to several proteins with known roles in disease, we can potentially apply these structural insights to design new compounds for a variety of therapeutic applications,” said David P. Marciano, first author of the study. (IANS)

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Researchers Identifies Causes of Osteoporosis in Older Adults

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Osteoporosis
Bone loss in adults. IANS

New York, Sep 25, 2017: Researchers have identified a mechanism that leads to bone loss in older adults, an advance that may help develop therapeutics to treat the age-associated bone loss condition.

Osteoporosis — the thinning of bone and the loss of bone density that increases the risk of fractures — is a major health problem in older people.

Often the condition is accompanied by an increase in fat cells in the bone marrow.

The study led by Yi-Ping Li, Professor at the University of Alabama at Birmingham, found a protein called Cbf-beta which plays a critical role in maintaining the bone-producing cells.

Furthermore, the examination of aged mice showed dramatically reduced levels of Cbf-beta in bone marrow cells as compared to younger mice.

The findings showed when this mechanism malfunctions, progenitor cells stop creating bone-producing cells and instead create fat cells.

Thus, maintaining this Cbf-beta may be essential to prevent human age-associated osteoporosis that is due to elevated creation of fat cells, Li said.

The results were published in the journal Proceedings of the National Academy of Sciences.

Knowledge of this mechanism can provide targets in the search for novel bone-loss therapeutics to treat human osteoporosis with minimal side effects, the researchers noted. (IANS)

 

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Love Hot Served Food? Caution: These 10 Foods May Turn Toxic Upon Reheating

Here is the rundown of 10 foods that you ought to abstain from reheating to keep its supplements rich

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Reheating some food may be dangerous to health. Pixabay

Sep 01, 2017: Food function as the fuel for your body and you should put every effort to have a robust and healthy food. The foods you devour include supplements, vitamins, fiber, protein, and minerals, which combine to help your body keep going.

Many of us indulge in the practice of reheating the food while eating. But few nourishments could transform into dangerous components in the wake of reheating. The reality will astound you, however, don’t stress.

Here is the rundown of 10 foods that you ought to abstain from reheating to keep its nutrients rich.

1. Rice

Rice. Pixabay

Most of you store rice in the wrong way, which in turn, can be toxic. The spores available in the raw rice can turn into bacteria, which multiply at the room temperature and may induce diarrhea and vomiting.

2. Potatoes

Potatoes. Pixabay

Potatoes are the favorite for many of us, but shockingly, potatoes lose their nutritional value when reheated. Toxic potatoes can breed illness, nausea, and induce food poisoning.

3. Spinach

Spinach. Pixabay

Just like any other green leafy vegetable, Spinach is rich in iron and nitrates. Upon reheating it, the nitrates turn into nitrites which can lead to cancer in living tissue.

4. Oils

Olive Oil. Pixabay

Some oils such as grape seed oil, walnut oil, flaxseed oil, hazelnut oil, and avocado oil have extremely low smoke limits.If you reheat them, they become unhealthy to devour.

Also Read: List of 8 Food Items to Battle Depression and Anxiety 

5. Egg

Egg. Pixabay

Reheating eggs at high temperature makes them poisonous and upon devouring them, your digestive system may fall sick.

6. Chicken

Fried Chicken. Pixabay

Chicken, the rich source of protein also create a negative impact after reheating. Eating such chicken may become a problem for you.

7. Turnips

Turnips. Pixabay

Turnips contain nitrates which can become toxic for health if reheated. Ordinarily, turnips are used in preparing soups.

8. Mushrooms

Mushrooms. Pixabay

Here is one thing about Mushroom, everyone should know: It should be utilized on the same day they are cooked, as they are a rich source of protein. Mushrooms upon reheating may change its structure which can be harmful to your body and causes severe heart problems.

9. Beets

Beetroot. Pixabay

Beets also include a high proportion of nitrates, which upon reheating can turn into nitrites and can prove to be problematic for your health.

10. Celery

Celery. Pixabay

Celery also carries a high rate of nitrate. It turns into nitrites after reheating, which increases the risk of methemoglobinemia, a blood disorder.


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Researchers discover Protein that can help make Vaccinations more effective, also protection from Cancer

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Cancer patient in hospital. Wikimedia

New York, April 8, 2017: Researchers have discovered a protein that could help make vaccinations more effective and also provide protection from other diseases such as cancer.

The researchers purified a protein found on the exterior of bacteria (neisseria meningidis) and used it as an accessory to provide a better vaccination response.

Typically, vaccines can either increase the amount of antibody production or they can stimulate cells (called cytotoxic T cells) to directly kill the offending agent.

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The protein, called PorB, is unique in that it can do both, the researchers said.

The study, published online in the journal Scientific Reports, may lead to greater understanding of how vaccine enhancers work and can best be used.

“This study has wide implications as it could not only be used to help the body identify and fight off bacterial infections, but it could also potentially help the body use its own machinery to fight off other diseases like cancer, HIV, and influenza before they have a chance to establish within the body,” explained corresponding author Lee Wetzler, Professor of Medicine and Microbiology at Boston University School of Medicine (BUSM) in the US.

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In this study, the researchers used two experimental models. The first model was given a vaccination with antigen and mixed PorB, while the second model was given the antigen alone.

The model that received the PorB had an increase in the response to the vaccine antigen, evidenced by an increased number of activated cells in the lymph nodes and a gain in the production of cytotoxic T cells, as compared to the vaccination with the antigen alone.

“Our study deepens the general understanding of how vaccine adjuvants modulate immune responses,” Wetzler said.

“The antigen formulation with PorB triggers a sequence of cellular events at the periphery and in lymphoid tissue that are critical for the establishment of protection to a broad array of infectious diseases, and maybe for other diseases like cancer,” Wetzler added. (IANS)