Sunday, April 18, 2021
Home Life Style Health & Fitness 13 New Rare Genomic Variants Associated With Alzheimer Disease Discovered

13 New Rare Genomic Variants Associated With Alzheimer Disease Discovered

Rare gene variants are the dark matter of the human genome

Researchers have identified 13 new rare genomic variants associated with Alzheimer’s disease in a first-of-its-kind human genome study. The lesser-known gene mutations may hold critical information about the biology of the disease and can lead to the development of new drugs for the devastating neurological condition, according to researchers from the Massachusetts General Hospital (MGH) in the US.

The Alzheimer Disease new gene variants are linked with the functioning of synapses — the junctions that transmit information between neurons — the development of neurons and neuroplasticity — the ability of neurons to reorganize the brain’s neural network. “This paper brings us to the next stage of disease-gene discovery by allowing us to look at the entire sequence of the human genome and assess the rare genomic variants, which we couldn’t do before,” said lead author Dmitry Prokopenko from MGH’s McCance Center for Brain Health.

Follow NewsGram on Instagram to keep yourself updated.

The results are published in the Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. “Rare gene variants are the dark matter of the human genome,” said Rudolph Tanzi, director of the hospital’s Genetics and Ageing Research Unit. Of the three billion pairs of nucleotide bases that form a complete set of DNA, each person has 50 to 60 million gene variants — and 77 percent are rare, he added.

ALSO READ: Let’s Celebrate World Alzheimer’s Day!

For the study, the researchers performed whole-genome sequencing on the genomes of 2,247 individuals from 605 families that include multiple members who have been diagnosed with AD. They also analyzed genome sequencing datasets on 1,669 unrelated individuals. (IANS/SP)

STAY CONNECTED

19,517FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

‘Godzilla’ Shark Discovered In New Mexico Is Given A Formal Name

The 300-million-year-old shark's teeth were the first sign that it might be a distinct species. The ancient chompers looked less like the spearlike rows of...

Here’s How ISI detectives ‘manipulated’ FBI To Make Dawood’s Financier Walk Free From Jail

In a desperate bid to cover up the nexus between the D-Company and ISI from being exposed to the world, Pakistan's top sleuths allegedly...

Older Adults More Willing To Help Others As Compared To Younger Adults

New research has found that older adults are more willing to make an effort to help others as compared to younger adults. According to...

Explore The Heritage Of Punjab Through The Lens Of Documentary ‘The Bathinda Fort’

With a view to inspire the younger generation about the glorious historical and cultural heritage of Punjab, senior Advisor to Chief Minister Lt Gen...

Know About The Six Nepali Women Creating A Record Feat

Six Nepali women have reached the top of Mt. Annapurna creating a record feat on the 8,091-metre tall peak, the Himalayan nation's Department of...

Study: Covid19 Likely Not To Effect The Brain Directly

SARS-CoV-2, the virus that causes Covid-19, likely does not directly infect the brain but can still inflict significant neurological damage, a new study suggests....

Explained: The Connection Between Hindus And Yazidis

BY- JAYA CHOUDHARY The Yezidis are the Kurdish religious minorities from countries like Iraq, Syria, Iran, and Turkey. With the news focusing on the culture...

Spiritual Power To Guard, ‘Jai Shri Ram’ Printed Mask More In Demand

As the second wave of covid19 is increasing everywhere especially in Maharashtra and other states. The only possible way to protect yourself is to...

Recent Comments