Friday June 22, 2018

A new substance may help fight tuberculosis: study

0
//
71
A new substance may help fight tuberculosis: study
A new substance may help fight tuberculosis: study. wikimedia commons
Republish
Reprint

London, Dec 29, 2017: Researchers have discovered a substance that may help combat the bacterium that causes life-threatening tuberculosis (TB) infections.

The substance, called beta lactone EZ120, interferes with the formation of the bacterium’s mycomembrane.

As this membrane is known to hamper the effect of many medications, this new substance offers hope of fighting the bacteria that can develop resistance to the antimicrobial drugs.

It is effective even in low concentrations and when combined with known antibiotics their effectiveness is improved by up to 100-fold, the study said.

“Vancomycin, a common antibiotic, and EZ120 work together very well,” said lead researcher Stephan Sieber, Professor of Organic Chemistry at Technical University of Munich in Germany.

“When used together, the dose can be reduced over 100-fold,” Sieber said.

The mycomembrane of the tuberculosis pathogen Mycobacterium tuberculosis consists of a lipid double layer that encapsulates the cell wall, forming an exterior barrier.

The researchers found that the substance can inhibit the biosynthesis of the mycomembrane and kills mycobacteria effectively.

Using enzyme assays and mass spectroscopy investigations, Johannes Lehmann of Technical University of Munich demonstrated that the new inhibitor blocks especially the enzymes Pks13 and Ag85, which play a key role in the development of mycomembranes.

The scientists suspect that disrupting the mycomembrane enables antibiotics to enter the bacteria more easily.

“This is a new mode of action and might be a starting point for novel tuberculosis therapies,” Sieber said. (IANS)

Click here for reuse options!
Copyright 2017 NewsGram

Next Story

Can Vinegar be Used to Treat Tuberculosis?

There is a real need for less toxic and less expensive disinfectants that can eliminate TB and non-TB mycobacteria, especially in resource-poor countries

0
Can Vinegar be Used to Treat Tuberculosis?
Can Vinegar be Used to Treat Tuberculosis? Pixabay

An international team of researchers has found that an active ingredient in vinegar can effectively kill mycobacteria, even the highly drug-resistant mycobacterium tuberculosis.

Acetic acid in vinegar might be used as an inexpensive and non-toxic disinfectant against drug-resistant tuberculosis (TB) bacteria as well as other stubborn, disinfectant-resistant mycobacteria, they found.

“For now, this is simply an interesting observation. Vinegar has been used for thousands of years as a common disinfectant and we merely extended studies from the early 20th century on acetic acid,” explained Howard Takiff, head of the laboratory of molecular genetics at the Venezuelan Institute of Scientific Investigation (IVIC) in Caracas, Venezuela.

Mycobacteria are known to cause tuberculosis and leprosy, but non-TB mycobacteria are common in the environment, even in tap water, and are resistant to commonly used disinfectants.

vinegar
Representational image. Pixabay

While investigating the ability of non-TB mycobacteria to resist disinfectants and antibiotics, Takiff’s postdoctoral fellow Claudia Cortesia stumbled upon vinegar’s ability to kill mycobacteria.

Testing a drug that needed to be dissolved in acetic acid, Cortesia found that the control with acetic acid alone, killed the mycobacteria she wanted to study.

“After Claudia’s initial observation, we tested for the minimal concentrations and exposure times that would kill different mycobacteria,” noted Takiff.

Also Read: Heartbreak May Help in Losing Weight

“There is a real need for less toxic and less expensive disinfectants that can eliminate TB and non-TB mycobacteria, especially in resource-poor countries,” Takiff observed.

Whether it could be useful in the clinic or labs for sterilising medical equipment or disinfecting cultures or clinical specimens remains to be determined, said the study published in mBio, the online journal of the American Society for Microbiology. (IANS)