Friday January 24, 2020

Sex Hormone Levels Linked to Heart Disease in Post-Menopausal Women

Postmenopausal women with high testosterone at heart disease risk

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Sex Hormone Levels Linked to Heart Disease in Post-Menopausal Women
Sex Hormone Levels Linked to Heart Disease in Post-Menopausal Women. Pixabay

Postmenopausal women with a higher blood level of the testosterone male hormone and a higher ratio of the oestrogen hormone could be at a higher risk of developing heart disease later in life, finds a study.

Among post-menopausal women, a higher ratio of testosterone/oestradiol — a major oestrogen produced in the ovaries — was associated with an elevated risk for incident cardiovascular disease (CVD), coronary heart disease and heart failure events, while higher levels of testosterone were associated with increased CVD and coronary heart disease.

On the other hand, higher oestradiol levels were associated with a lower coronary heart disease risk.

“Although sex hormone levels may be linked to future cardiovascular events, it is unclear what the best intervention is to modify sex hormone levels for risk reduction,” said Erin D. Michos, Associate Professor at the Johns Hopkins University in Maryland, US.

Representational image.
Representational image. Pixabay

“However, a sex hormone profile higher in male hormones may identify a woman at higher risk for cardiovascular disease who may benefit from other risk reduction strategies,” Michos added.

The risk for cardiovascular disease is much lower in women than men until women reach the age of 50 years of age, then risk rises dramatically after menopause.

Previous studies have demonstrated that higher androgen and lower oestrogen levels are associated with risk factors for heart disease in post-menopausal women; however, other studies show conflicting results, so the relationship between sex hormones and cardiovascular events in post-menopausal women remains unclear.

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The new research, published in the Journal of the American College of Cardiology, evaluated the association of sex hormone levels with incident cardiovascular disease, over a 12-year follow-up in 2,834 post-menopausal women free of cardiovascular disease at baseline.

Sex hormone concentrations were measured using fasting serum samples. Sex hormone levels after menopause were associated with women’s increased risk of CVD in later life. (IANS)

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Premature Menopause More Likely to Increase Health Problems After 60

Compared with women who experienced menopause at the age of 50-51 years, women with premature menopause were twice as likely to develop multimorbidity by the age of 60, and three times as likely to develop multimorbidity from the age of 60 onwards

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Bone Health
Women who have already been through menopause may experience problems related to their bone health. Lifetime Stock

Women who experience premature menopause are almost three times more likely to develop multiple, chronic medical problems in their 60s, says a new study.

It is known already that premature menopause, occurring at the age of 40 or younger, is linked to a number of individual medical problems in later life, such as cardiovascular disease and diabetes.

However, there is little information about whether there is also an association between the time of natural menopause and the development of multiple medical conditions known as multimorbidity.

For the findings, published in the journal Human Reproduction, researchers at the University of Queensland followed more than 5,000 women aged 45 to 50 from 1996 until 2016.

“We found that 71 per cent of women with premature menopause had developed multimorbidity by the age of 60 compared with 55 per cent of women who experienced menopause at the age of 50-51,” said study researcher Xiaolin Xu from Zhejiang University in China.

“In addition, 45 per cent of women with premature menopause had developed multimorbidity in their 60s compared with 40 per cent of women who experienced menopause at the age of 50-51,” Xu added.

The women responded to the first survey in 1996 and then answered questionnaires every three years (apart from a two-year interval between the first and second survey) until 2016.

Sexual Dysfunction increases by nearly 30 per cent during perimenopause and vaginal dryness most often has the greatest effect on desire, arousal and overall satisfaction, Here are some Causes. Wikimedia Commons

The women reported whether they had been diagnosed with or treated for any of 11 health problems in the past three years: diabetes, high blood pressure, heart disease, stroke, arthritis, osteoporosis, asthma, chronic obstructive pulmonary disease, depression, anxiety or breast cancer.

Women were considered to have multimorbidity if they had two or more of these conditions.

During the 20 years of follow-up, 2.3 per cent of women experienced premature menopause and 55 per cent developed multimorbidity.

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Compared with women who experienced menopause at the age of 50-51 years, women with premature menopause were twice as likely to develop multimorbidity by the age of 60, and three times as likely to develop multimorbidity from the age of 60 onwards.

“Our findings indicate that multimorbidity is common in mid-aged and early-elderly women,” said Indian-origin researcher and study senior author Gita Mishra.

“We also found that premature menopause is associated with a higher incidence of individual chronic conditions,” Xu added. (IANS)