Saturday January 18, 2020

Nerve Cell Cancer Survivors, At Higher Risk Of Developing Depression

The data were compared with the additional data from 872 siblings.

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Nerve Cell Cancer Survivors, At Higher Risk Of Developing Depression
Nerve Cell Cancer Survivors, At Higher Risk Of Developing Depression, Pixabay

Researchers have found that patients who suffered from pediatric neuroblastoma — a childhood cancer of nerve cells — may have a higher risk of developing long term psychological difficulties, including depression and attention deficit disorders.

“These findings are novel because this is the first large study that could look at how neuroblastoma patients are doing in terms of psychological and educational outcomes,” said one of the researchers Nina Kadan-Lottick from Yale University School of Medicine in the US.

“Our hope is that these findings will help inform strategies for early screening and intervention to identify those survivors at highest risk for developing psychological and educational impairment later on in life,” Lottick explained.

The study, published in the journal Cancer, analysed data from 859 children who had been diagnosed with neuroblastoma at least five years earlier and were under 18 years old. The data were compared with the additional data from 872 siblings of these patients.

A nerve
A nerve, Representational image, flickr

The results showed that neuroblastoma survivors had 19 per cent increased prevalence of impairment in the domains of anxiety or depression as opposed to 14 per cent among the siblings.

The team also found that 19 per cent increased risk of headstrong behaviour among the patients as opposed to 13 per cent among the sibling group.

The patients group had 21 per cent higher prevalence of attention deficit disorders and 16 per cent higher risk of antisocial behaviour compared to 13 per cent and 12 per cent risk respectively in the sibling group.

Treatment advances in recent years have prolonged survival for many children diagnosed with neuroblastoma, but their young age at diagnosis and the specific therapies they receive can make them vulnerable to health problems as their central nervous system develops, the study said.

Mental patient
Mental patient, representational image, flickr

Also read: Finally the cause of depression among diabetes patients decoded

“The goal is not simply to get our patients to be cancer-free but also to optimise their mental, emotional, and social functioning as they move into adolescence and adulthood,” Lottick said. (IANS)

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Consumption of Soybean Oil May Affect Neurological Conditions: Study

Soybean oil diet may trigger genetic changes in brain

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Soybean oil
Soybean oil not only leads to obesity and diabetes but may also affect neurological conditions. Wikimedia Commons

Widely consumed soybean oil not only leads to obesity and diabetes but may also affect neurological conditions like autism, Alzheimer’s disease, anxiety and depression, report researchers from University of California Riverside, including one of Indian origin.

In a study conducted on mice, the scientists found pronounced effects of the soybean oil on the hypothalamus where a number of critical processes take place.

The research team discovered nearly 100 genes – including the ‘love hormone’ oxytocin produced in hypothalamus — affected by the soybean oil diet.

Soybean oil  brain
In a study conducted on mice, the scientists found pronounced effects of the soybean oil on the hypothalamus where a number of critical processes take place. Pixabay

“The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and physical growth as well as your response to stress,” said Margarita Curras-Collazo, an associate professor of neuroscience and lead author on the study published in the journal Endocrinology.

The research team has not yet isolated which chemicals in the oil are responsible for the changes they found in the hypothalamus.

“But they have ruled out two candidates. It is not linoleic acid, since the modified oil also produced genetic disruptions; nor is it stigmasterol, a cholesterol-like chemical found naturally in soybean oil,” the study noted.

Identifying the compounds responsible for the negative effects is an important area for the team’s future research.

“This could help design healthier dietary oils in the future,” said Poonamjot Deol, first author on the study.

“If there’s one message I want people to take away, it’s this: reduce consumption of soybean oil,” Deol added.

Soybean oil brain
Consumption of Soybean oil may lead to autism. Pixabay

The team compared mice fed three different diets high in fat: soybean oil, soybean oil modified to be low in linoleic acid, and coconut oil.

They believe this discovery could have ramifications not just for energy metabolism,but also for proper brain function and diseases such as autism or Parkinson’s disease.

“However, it is important to note there is no proof the oil causes these diseases,” the authors wrote.

Te same research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance.

The team said the findings only apply to soybean oil — not to other soy products or to other vegetable oils.

“Do not throw out your tofu, soymilk, edamame, or soy sauce,” said Frances Sladek, a UCR toxicologist and professor of cell biology.

“Many soy products only contain small amounts of the oil, and large amounts of healthful compounds such as essential fatty acids and proteins”.

Also Read- Excessive Cardio Can Make you Gain Weight

This study utilized male mice. Because oxytocin is so important for maternal health and promotes mother-child bonding, similar studies need to be performed using female mice.

Coconut oil, which contains saturated fats, produced very few changes in the hypothalamic genes, said the researchers. (IANS)