Tuesday December 18, 2018

3-D miniature Female Reproductive System may Boost Safety and Effectiveness in testing New Drugs

The device has a series of cables and pumps that cause media (simulated blood) to flow between wells and will open doors into the causes of endometriosis, fibroids and some cancers

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New York, March 29, 2017: Scientists have, in a breakthrough, developed a 3-D based miniature female reproductive tract that will boost safety and effectiveness in testing new drugs for diseases such as fibroids, endometriosis, cancer and infertility in women’s reproductive organs.

The new 3-D device — called EVATAR — is made with human tissue, can fit in the palm of your hand, and could help use stem cells of an individual patient and create a personalised model of their reproductive system.

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“This is nothing short of a revolutionary technology. It’s the ultimate personalised medicine, a model of your body for testing drugs,” said lead investigator Teresa Woodruff, a reproductive scientist and Director at Northwestern University in the US.

“This will help us develop individualised treatments and see how females may metabolise drugs differently from males,” Woodruff added.

The organ models are able to communicate with each other via secreted substances, including hormones, to closely resemble how they all work together in the body, mimicking what is actually happening in the body, the researchers said in the paper published in the journal Nature Communications.

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The device has a series of cables and pumps that cause media (simulated blood) to flow between wells and will open doors into the causes of endometriosis, fibroids and some cancers.

The system also will allow scientists to test millions of compounds in the environment and new pharmaceuticals to understand how they affect the reproductive system and many other organs in the body.

“This technology will help us look at drug testing and drug discovery in a brand new way,” Woodruff said. (IANS)

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USA: Everything you want to know about Security Clearance; Find out here!

A security clearance allows a person access to classified national security information or restricted areas.

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Former CIA Director John O. Brennan speaks at the Council on Foreign Relations in Washington, March 11, 2014. President Donald Trump revoked Brennan's security clearance Wednesday. VOA
Former CIA Director John O. Brennan speaks at the Council on Foreign Relations in Washington, March 11, 2014. President Donald Trump revoked Brennan's security clearance Wednesday. VOA

U.S. President Donald Trump on Wednesday revoked the security clearance of former CIA Director John Brennan. We take a look at what that means.

What is a security clearance?

A security clearance allows a person access to classified national security information or restricted areas after completion of a background check. The clearance by itself does not guarantee unlimited access. The agency seeking the clearance must determine what specific area of information the person needs to access.

What are the different levels of security clearance?

There are three levels: Confidential, secret and top secret. Security clearances don’t expire. But, top secret clearances are reinvestigated every five years, secret clearances every 10 years and confidential clearances every 15 years.

All federal agencies follow a list of 13 potential justifications for revoking or denying a clearance. VOA
All federal agencies follow a list of 13 potential justifications for revoking or denying a clearance. VOA

Who has security clearances?

According to a Government Accountability Office report released last year, about 4.2 million people had a security clearance as of 2015, they included military personnel, civil servants, and government contractors.

Why does one need a security clearance in retirement?

Retired senior intelligence officials and military officers need their security clearances in case they are called to consult on sensitive issues.

Also Read: Governments Across The World Request Apple for 30,000 Device Information

Can the president revoke a security clearance?

Apparently. But there is no precedent for a president revoking someone’s security clearance. A security clearance is usually revoked by the agency that sought it for an employee or contractor. All federal agencies follow a list of 13 potential justifications for revoking or denying a clearance, which can include criminal acts, lack of allegiance to the United States, behavior or situation that could compromise an individual and security violations. (VOA)