Thursday February 21, 2019

40% of Women with Asthma Have a Risk of Developing Chronic Lung Diseases

Previous studies have found an alarming rise in ACOS in women in recent years and that the mortality rate from ACOS was higher in women than men.

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Obesity, Asthma
They found that 10.2 per cent of people with asthma at the start of the study had become obese ten years on Flickr Commons

More than 4 in 10 individuals with asthma run the risk of developing chronic obstructive pulmonary disease (COPD), a group of lung diseases that block airflow and make it harder to breathe, says a new study involving around 4,000 women.

The researchers examined risk factors for developing asthma and COPD overlap syndrome, known as ACOS.

The findings, published in the journal Annals of the American Thoracic Society, showed that individual risk factors played a more significant role in the development of ACOS than exposure to fine particulate matter, a major air pollutant that because of its microscopic size penetrates deep into the lungs.

Women who had smoked more than the equivalent of a pack of cigarettes a day for five years, were much more likely to develop ACOS than those who smoked fewer cigarettes or never smoked.

However, ACOS did not affect only those who smoke as the researchers found that 38 per cent of the women who developed ACOS in the study had never smoked.

Lady With An Asthma Inhaler
The study also identified obesity, rural as significant risk factors for ACOS. VOA

The study also identified obesity, rural residence, lower education levels and unemployment as significant risk factors for ACOS.

The authors believe that these factors may result in suboptimal access to care, under-treatment of asthma and poor compliance to medications, all of which lead to more frequent asthma attacks.

These attacks in turn may lead to airway remodelling that increases the chances of developing ACOS.

Also Read: Lung Function Decline in Elderly Can be Delayed by Consuming Flavonoid

“Previous studies have found an alarming rise in ACOS in women in recent years and that the mortality rate from ACOS was higher in women than men,” said Teresa To, Professor atUniversity of Toronto in Canada.

“We urgently need to identify and quantify risk factors associated with ACOS in women to improve their health and save lives,” To added. (IANS)

Next Story

Fish Oil Supplements May Not Improve Asthma Symptoms, Says Study

New therapeutic interventions to reduce airway inflammation and facilitate improved asthma control are greatly needed, the team suggested

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Man about to use asthma inhaler

Fish oil supplements, once touted as the natural substance that could alleviate many of your chronic ailments, may not prove to be helpful to obese/overweight adolescents and young adults with uncontrolled asthma, new research suggests.

The study, published in the American Journal of Respiratory and Critical Care Medicine, showed that four grams of fish oil a day for six months did not improve asthma control, as measured by a standard asthma control questionnaire, breathing tests, urgent care visits and severe asthma exacerbations.

“We don’t know why asthma control in obese patients is more difficult, but there is growing evidence that obesity causes systemic inflammation,” said lead author Jason E. Lang, Associate Professor at the Duke University in the US.

“Because the omega-3 fatty acids in fish oil have anti-inflammatory properties, we wanted to test whether fish oil would have therapeutic benefits for these patients,” Lang added.

The team included nearly 100 overweight or obese participants aged 12 to 25 and found that the participants had poor asthma control despite using a daily inhaled corticosteroid to control their asthma.

For every three participants assigned to take fish oil for 25 weeks, one was assigned to take the soy oil placebo.

Supplements
Fish oil may not improve asthma symptoms: Study. Pixabay

In addition, the team also looked at whether a variant in the gene ALOX5 affected the findings. It is known that mutations in the gene can reduce responses to anti-leukotriene drugs.

Leukotrienes are inflammatory molecules that play a critical role in triggering asthma attacks. In this study, the ALOX5 variant did appear to be linked to leukotriene production but not to the effectiveness of fish oil in providing asthma control.

The researchers noted that the study’s negative findings may not be the last word on fish oil and asthma and acknowledged that larger doses of fish oil over a longer period of time may produce a different result.

Also Read- Aspirin, ibuprofen Can Improve Survival Rate of Cancer Patients

However, based on the current study, “there is insufficient evidence for clinicians to suggest to patients with uncontrolled asthma that they should take daily fish oil supplements to help their asthma”, said Lang.

New therapeutic interventions to reduce airway inflammation and facilitate improved asthma control are greatly needed, the team suggested. (IANS)