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Novel drug may offer treatment for TB. Pixabay

Researchers have found a molecule that is effective against tuberculosis, says a new study on mice.

In the study, the group describes how it worked when tested in vitro and in a mouse model.


Tuberculosis is a bacterial infection caused by Mycobacterium tuberculosis (Mtb). This airborne pathogen tends to infect the lungs and is passed from person to person.

Back in the 1950s, researchers developed drugs to treat the disease.However, since that time, the bacteria has become resistance today, and almost one-third of all new cases are caused by antimicrobial-resistant strains.


Researchers identify molecule 8918 effective in killing TB bacteria. (Representational image). IANS

In this new effort, published in the journal Science, the researchers from University of Cape Town in South Africa, found that introducing the 8918 molecule to Mtb in a petri dish resulted in its death.

In addition, they also found that administering the molecule to Mtb mouse models killed some of the bacteria they carried without harming them.

Also Read- Lower BMI in Children Can Raise Risk of Eating Order

However, before 8918 can be considered a candidate for clinical trials, researchers must overcome one obstacle — it has a short half-life, which results in rapid microsomal metabolism indicating that it does not hang around long enough to kill many Mtb before the body flushes it away, the study noted. (IANS)


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Actress Kangana Ranaut has talked about how her weight adjustments for her latest 'Thalaivii' that "messed up many things" in her body

Actress Kangana Ranaut has talked about how her weight adjustments for her latest 'Thalaivii' that "messed up many things" in her body and left her with "permanent stretch marks". For her role in the film, based on the life of late Tamil Nadu Chief Minister and former actress J. Jayalalithaa, Kangana had to gain 20kg and undergo major physical transformation several times.

She took to Instagram to share her experience, detailing that doing all that over the six months period left her with "permanent stretch marks". "Gaining 20 kgs in 6 months and loosing it all within 6 months that too in my thirties messed up many things in my bodya I also have permanent stretch marks as well but art comes to life with a price and more often than not price is the artist him/herself," she wrote.

"Thalaivii" showcases the varied aspects of Jayalalithaa's life, tracing her journey as an actress at a young age to becoming the face of Tamil cinema, as well as the rise of the revolutionary leader who changed the course of the state's politics. Talking about her upcoming works, Kangana currently has 'Dhaakad'.

She is also shooting for her next 'Tejas', where she plays a fighter pilot. The Indian Air Force was the first of the country's defence forces to induct women into combat roles in 2016. The film takes inspiration from the landmark event. 'Tejas' is directed by debutant Sarvesh Mewara. The film will be RSVP's second film which pays a tribute to the Indian military after the immensely successful film "Uri: The Surgical Strike" which was released in January 2019. (IANS/ MBI)


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Signal's encrypted messaging app continues to be down on Monday after facing global outage on Sunday.

Signal's encrypted messaging app continues to be down on Monday after facing global outage on Sunday. The firm said it is working to fix it. "Hold tight, folks! Signal is currently down, due to a hosting outage affecting parts of our service. We're working on bringing it back up," the firm said in a tweet on Sunday.

The status website says the encrypted messaging app is "experiencing technical difficulties" and many people are also getting an in-app error message that says the same thing. Signal allows for secure and encrypted video, voice and text communication, but users are unable to send any messages.

According to Downdetector.com, users started reporting outages around 11:05 PM Eastern Standard Time and it appears to be affecting people around the world. Comments shared on Downdetector.com indicates that Signal was down for users from India, US, Germany, New Zealand, Netherlands, Australia, Brazil and many other countries.

"Down in Midwest USA. Signal was started by people connected to which secret 3-letter organization? (Look it up) Yep, that's right! An app disguised a privacy app to trick you into sharing more private information than you would with another messaging app," a user said. "I think Signal is having a rough day. Good luck, Team Signal. I'm sure you'll have it sorted out in a snap," said another. The encrypted messaging service has climbed to the top spot in the free apps category of the App Store in multiple countries, including India. (IANS/ MBI)


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Photo by Jeremy Bezanger on Unsplash

This issue will be fixed in an upcoming software update.

Apple has acknowledged an issue where the "unlock with Apple Watch" feature might not work with its new iPhone 13 devices and promised to fix this issue with an upcoming software update. "You might see 'Unable to Communicate with Apple Watch' if you try to unlock your iPhone while wearing a face mask, or you might not be able to set up Unlock with Apple Watch," the iPhone maker said in the support document.

This issue will be fixed in an upcoming software update. Until the update is available, you can turn off Unlock with Apple Watch and use your passcode to unlock your iPhone 13. To turn off Unlock with Apple Watch, go to Settings > Face ID & Passcode.

Earlier, multiple users found that they cannot unlock their iPhone 13 with the Apple Watch and instead received an error. User Monzilla88 on Reddit first reported the issue to the subreddit r/AppleWatch. They stated that both their iPhone 13 Pro and Apple Watch SE are up to date with the newest iOS and watchOS updates.

"Whenever I try to enable unlock with Apple Watch on my phone I get an error saying "Unable to communicate with Apple Watch," they posted. Monzilla88 claimed that they had tried unpairing and repairing, hard resetting both devices, turning on and off passcodes, but not no avail, the report said. More than 20 other users self-reported the same problem, with others noting that the feature works fine on iOS 15 on older models of iPhone, including the iPhone 11 Pro Max and the iPhone X. (IANS/ MBI)


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