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Patients on chemotherapy that is toxic to cells developed antibody response

Nearly 95 per cent of people with cancer developed a good immune response to the Covid-19 mRNA vaccines three to four weeks after receiving their second dose, finds a new study co-authored by Indian-origin researchers.

The study, published in the journal Cancer Cell, indicated that among the 131 patients studied, 94 per cent developed antibodies to the coronavirus.

Seven high-risk patients did not.

"We could not find any antibodies against the virus in those patients," said researcher Dimpy P. Shah from the University Of Texas Health Science Center at San Antonio.

Among the high-risk groups, patients receiving a therapy called Rituximab within six months of vaccination developed no antibodies. Rituximab is a monoclonal antibody used in the treatment of haematological cancers and autoimmune diseases.

Cancer The median age of patients in the study was 63 orange plastic bottle Photo by Unsplash


Patient on chemotherapy that is toxic to cells developed antibody response, but it was muted compared to the general population.

"How that relates to protection against COVID-19, we don't know yet," Dimpy Shah said.

The Delta variant and other mutants of the Covid-19 virus were not examined in the study. The team also did not analyze the response of infection-fighting T cells and B cells in patients with cancer.

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"Patients with haematological malignancies, such as myeloma and Hodgkin lymphoma, were less likely to respond to vaccination than those with solid tumours," said Pankil K. Shah from the Geneva University Hospital.

The median age of patients in the study was 63. Most of the patients (106) had solid cancers as opposed to haematological malignancies (25). (IANS/AD)


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The researchers exposed saliva samples from Covid-19 patients to the ACE2 gum and found that levels of viral RNA fell so dramatically to be almost undetectable.

A chewing gum laced with a plant-grown protein serves as a "trap" for the SARS-CoV-2 virus, reducing viral load in saliva and potentially tamping down transmission, finds a new study.

The researchers exposed saliva samples from Covid-19 patients to the ACE2 gum and found that levels of viral RNA fell so dramatically to be almost undetectable, indicates the study published in the journal Molecular Therapy.

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"SARS-CoV-2 replicates in the salivary glands, and we know that when someone d sneezes, coughs, or speaks some of that virus can be expelled and reach others," said researcher Henry Daniell from the University of Pennsylvania in the US.

"This gum offers an opportunity to neutralise the virus in the saliva, giving us a simple way to possibly cut down on a source of disease transmission," Daniell added.

To test the chewing gum, the team grew angiotensin-converting enzyme 2 (ACE2) in plants, paired with another compound that enables the protein to cross mucosal barriers and facilitates binding, and incorporated the resulting plant material into cinnamon-flavoured gum tablets.

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