Wednesday September 19, 2018
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A Powerful Find that can change gene in Insects, Animals and Plants

Scientists are looking for ways to use this advance to curb diseases like malaria by destroying the problem at its stem itself

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genetics
Genetically Engineered Mosquitoes to combat Zika Virus. Image Courtesy: Getty Images
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  • Study shows that genes of an entire species can be modified 
  • This discovery was used in making malaria in Brazil that are resistant to Zika Virus
  • Few scientists are worried bioterrorists will cause havoc if this technology reaches their hands

Valentino Gantz, a graduate student, was recently successful in changing the genetic modelling of brown fruit flies in such a way they their offspring all turned out to be blonde. This discovery proved to be a milestone in the way genetics is understood by scientists. The changes that are made in the genes have the possibility of being passed on to newer generations. Fruit flies were used in particular since their biological settings help biologists study pathogens that cause human diseases.

“I believe it’s going to transform the world of genetics,” Biologist Ethan Bier says, “because it’s going to allow researchers to bypass the rules of genetics in many different spheres of activity.” Ethan Bier runs a laboratory at the University of California, San Diego.

What Gantz demonstrated was a new technique that could make that happen almost every time. Scientists call it a “gene drive.”

genetics
A Brown Fruit Fly. Image Courtesy: Wikimedia Commons

Gene drive is a breakthrough discovery by a panel of influential scientists of  National Academies of Sciences, Engineering and Medicine. The report that the panel came up with greatly appreciated the efforts that were put in to obtain these results. This means that, if done right, most of the major viruses that claim human lives today can be eradicated. An example is the use of genetically influenced mosquitoes that were released in Brazil to combat the vicious Zika virus.

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However, there’s a long way to go before scientists can start using this information in today’s genetics. There is a very high possibility of mistakes at the molecular level, which will have exponential effects. Scientists cannot afford to disturb the delicate balance that exists in the ecosystems.

According to an independent report, “It’s possible that a particular altered trait could cause unexpected and possibly harmful side-effects on other organisms when spread through a particular species using a drive. The risks will primarily depend on the alteration and species rather than on the drive itself. This is why proposed gene drive must be evaluated on a case-by-case basis – it’s all about the trait, species and ecosystem in question.”

genetics
Academics of Sciences, Engineering and Medicines. Image Courtesy: Wikimedia Commons

Scientists who work in the field of genetics have been able to make changes in the gene for decades, but what is exciting about this new discovery is that now, a change in an organism can be quickly passed on to the next generation, and eventually an entire species. This is achieved by creating a change in the sequence of the DNA molecule itself.

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Scientists are looking for ways to use this advance to curb diseases like malaria by destroying the problem at its stem itself. Mosquitoes are being genetically modified so that they can no longer carry the parasite.

Anthony James of the University of California, Irvine, one of the scientists who created the mosquitoes that can block malaria, lauded the report for providing a calculated framework while performing the research. “I think it’s actually fair and balanced and well done,” James says. “I think they did a really good job.”

However, there are experts who fear if this technology is placed in the wrong hands, it can be used by bioterrorists to create large scale havoc. Not only will it destroy ecosystems, but also allow evolution of new diseases and spread the reach of existing diseases to new areas.

-by Saurabh Bodas, an intern at NewsGram. Twitter: @saurabhbodas96

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  • Pashchiema Bhatia

    Genetics is the most complicated study in Biology and has proved itself in curing a lot of diseases. Still a lot more can be achieved through it.

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Huge Fire In California Probably Due To Climate Change: Experts

The California summit will look at ways to build consensus and avoid worst-case scenarios. Protesters who have gathered in San Francisco, however, say it is not enough.

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Climate Change Fuels California Fires. Flickr

California has experienced record heat waves and catastrophic fires in recent years, and climate experts say it is likely to get worse.

A report released Aug. 27 by the state of California, the fourth in a series of assessments, puts the blame squarely on climate change.

California Gov. Jerry Brown is hosting an international summit, beginning Wednesday, in San Francisco to search for solutions.

The worst fires in California’s history came this year and last, with the 2018 Mendocino Complex Fire scorching 186,000 hectares. Parts of northern California are still burning. The largest of the fires, in Shasta County, has burned more than 20,000 hectares and is only 5 percent contained.

Climate research

The California Climate Change Assessment summarizes current climate research and finds a litany of problems caused by greenhouse gases, including carbon dioxide, which is emitted by the use of fossil fuels such as coal and oil.

If nothing or little is done, the reports say to expect temperature rises of 3 to 5 degrees Celsius (5.6 to 8.8 degrees Fahrenheit) by 2100; a two-thirds decline in water supplies from the mountain snow pack by 2050; a nearly 80 percent increase in the area scorched by fires by the end of the century; and up to two-thirds of Southern California beaches eroding in the same time frame.

From flooding to a strained electrical grid and premature deaths and illnesses, the list is extensive.

“I think we’ve reached the point where the impacts of climate change are no longer subtle,” said Michael Mann, who directs the Earth System Science Center at Pennsylvania State University.

Mann was not involved in the study, but said he thinks its finding are, if anything, conservative.

“We are literally seeing them play out in real time in the form of record heat waves, floods, droughts and wildfires,” he said.

 

California
A firefighter sprays the smoldering remains of a vehicle on Interstate 5 as the Delta Fire burns in the Shasta-Trinity National Forest, VOA

 

The Trump administration, however, has pledged to overturn emissions curbs and has promised to withdraw from the 2015 Paris climate agreement, an accord of nearly 200 countries that requires national targets for emission cuts but which lacks enforcement powers.

President Donald Trump said the pact is ineffective and kills jobs. Climate expertssay something must be done to slow the climate shifts that are underway.

“A warmer atmosphere can hold more moisture, so there’s the potential for greater rainfall events, worse flooding,” Mann said. “A warmer atmosphere also dries out the soils, causing drought.”

He added, “You’re moving the probability curve, and at the tail of the curve are the extreme weather events.”

Health effects of climate change

Epidemiologists are tracking health effects of the changes, from more pollutants emitted by fires to warming in the cities, said epidemiologist Rupa Basu of the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment. Basu was a contributing author to California’s climate assessment.

“There’s a larger population living in urban areas, and more importantly, a larger vulnerable population living in urban areas,” said Basu, which she said become “urban heat islands” as temperatures rise. The report says that many rural communities, and Native Americans and other minorities, are disproportionately affected.

 

California
In this Sept. 5, 2018, photo released by the U.S. Forest Service, a truck drives next to the Delta Fire burning on Interstate 5 near Shasta-Trinity National Forest, Calif. VOA

 

Researchers are seeing more emergencies and deaths among the very young, elderly and poor. Analysts compare hospital and emergency room visits, infant birth weights, death and illness rates to temperature and relative humidity, researcher Xiangmei Wu said.

On a global level, climate change can increase the ferocity of tropical storms because of changes to the jet stream that determine weather patterns, although hurricanes are not an issue in California.

Mann, of the Earth System Science Center, said one of most destructive storms in U.S. history, Hurricane Harvey on the Gulf Coast, released huge amounts of rainfall as it stalled in its path over Houston in 2017. He said, “You’re moving that probability curve over” on the graph of weather patterns, “and at the tail of the curve are the extreme warm events.”

 

California
Gov. Jerry Brown discusses the goals of the global climate summit he is hosting in San Francisco and legislation he signed directing California to phase out fossil fuels for electricity by 2045 during an interview with The Associated Press. VOA

 

Extreme weather events

Dan Cayan, a researcher at the Scripps Institution of Oceanography and a coordinating lead author of the California report, said climate change exaggerates natural cycles such as El Nino, the periodic warming of equatorial oceans that leads to storms in the Pacific. He said more extreme weather events may well be on their way.

“State and local governments and other players are taking this seriously. And I think that trend will grow as climate change symptoms continue to bubble up,” Cayan said, adding that he is cautiously optimistic that the world can mitigate the worst effects of the changes.

Gov. Brown, who is hosting the three-day summit that ends Friday, has committed to reducing greenhouse gas emissions in his state to 40 percent below 1990 levels.

Monday, Brown signed a bill requiring California to obtain all of its electricity from clean energy sources by 2045.

Brown is a key figure in a coalition of local and regional governments that have committed to achieving the Paris accord’s limiting of global warming in this century to 1.5 to 2 degrees Celsius above pre-industrial levels, whether or not the United States remains in the agreement.

California
The Delta Fire burns in the Shasta-Trinity National Forest. VOA

The California summit will look at ways to build consensus and avoid worst-case scenarios.

Also Read: Smoke From Wildfire Makes Weather in West US Worse

Protesters who have gathered in San Francisco, however, say it is not enough.

“There have been many climate summits with a lot of rhetoric but not enough commitment,” activist May Boeve told The Associated Press. She was one of thousands who marched through San Francisco last Saturday, calling for a transition to renewable energy sources and protections for workers and minority groups as the world braces for dramatic changes to its weather.