Saturday December 7, 2019

Exposure to Air Pollution May Trigger Alzheimer’s in Aged Women, Reveals Research

"Our hope is that by better understanding the underlying brain changes caused by air pollution, researchers will be able to develop interventions to help people with or at risk for cognitive decline," Petkus added

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Alzheimer's
A lady suffering from Alzheimer's. Flickr

Women in their 70s and 80s who were exposed to higher levels of air pollution experienced greater declines in memory and more Alzheimer’s-like brain atrophy than their counterparts who breathed cleaner air, new research has revealed.

“This is the first study to really show, in a statistical model, that air pollution was associated with changes in people’s brains and that those changes were then connected with declines in-memory performance,” said study researcher Andrew Petkus, the Assistant Professor University of South California in the US.

Previous research has suggested that fine particle pollution exposure increases the risk for Alzheimer’s disease and related dementias.

What scientists haven’t known is whether PM2.5 alters brain structure and accelerates memory decline.

For the study, published in the journal Brain, researchers used data from 998 women, aged 73 to 87, who had up to two brain scans five years apart as part of the landmark Women’s Health Initiative launched in 1993 by the US National Institutes of Health and enrolled more than 160,000 women to address questions about heart disease, cancer, and osteoporosis.

"The question for us now is not how to eliminate cholesterol from the brain, but about how to control cholesterol's role in Alzheimer's disease through the regulation of its interaction with amyloid-beta," Vendruscolo said.
In Alzheimer’s disease, patients start losing memory. Pixabay

Those brain scans were scored on the basis of their similarity to Alzheimer’s disease patterns by a machine learning tool that had been “trained” via brain scans of people with Alzheimer’s disease.

The researchers also gathered information about where the 998 women lived, as well as environmental data from those locations to estimate their exposure to fine particle pollution.

When all that information was combined, researchers could see the association between higher pollution exposure, brain changes and memory problems — even after adjusting to taking into account differences in income, education, race, geographic region, cigarette smoking, and other factors.

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“This study provides another piece of the Alzheimer’s disease puzzle by identifying some of the brain changes linking air pollution and memory decline. Each research study gets us one step closer to solving the Alzheimer’s disease epidemic,” Petkus said.

“Our hope is that by better understanding the underlying brain changes caused by air pollution, researchers will be able to develop interventions to help people with or at risk for cognitive decline,” Petkus added. (IANS)

Next Story

Reduction in Air Pollution May Increase Life-Expectancy: Study

Findings of a Research indicate almost immediate and substantial effects on health outcomes followed reduced exposure to air pollution

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Pollution
Fortunately, reducing air Pollution can result in prompt and substantial health gains. Pixabay

Reductions in Air Pollution yielded fast and dramatic impacts on health-outcomes, as well as decreases in all-cause morbidity, a new study suggests.

The study, published in the journal Annals of the American Thoracic Society, reviewed interventions that have reduced air pollution at its source. It looked for outcomes and time to achieve those outcomes in several settings, finding that the improvements in health were striking.

Starting at week one of a ban on smoking in Ireland, for example, there was a 13 per cent drop in all-cause mortality, a 26 per cent reduction in ischemic heart disease, a 32 per cent reduction in stroke, and a 38 per cent reduction in chronic obstructive pulmonary disease (COPD). Interestingly, the greatest benefits in that case occurred among non-smokers.

“We knew there were benefits from pollution control, but the magnitude and relatively short time duration to accomplish them were impressive,” said lead author Dean Schraufnagel from the American Thoracic Society in the US.

“Our findings indicate almost immediate and substantial effects on health outcomes followed reduced exposure to air pollution. It’s critical that governments adopt and enforce WHO guidelines for air pollution immediately,” Schraufnagel added.

Pollution
Reductions in Air Pollution yielded fast and dramatic impacts on health-outcomes, as well as decreases in all-cause morbidity, a new study suggests. Pixabay

According to the researchers, In the US a 13-month closure of a steel mill in Utah resulted in reducing hospitalisations for pneumonia, pleurisy, bronchitis and asthma by half.

School absenteeism decreased by 40 per cent, and daily mortality fell by 16 per cent for every 100 µg/m3 PM10 (a pollutant) decrease.

Women who were pregnant during the mill closing were less likely to have premature births.

A 17-day ‘transportation strategy,’ in Atlanta, Georgia during the 1996 Olympic Games involved closing parts of the city to help athletes make it to their events on time, but also greatly decreased air pollution.

In the following four weeks, children’s visits for asthma to clinics dropped by more than 40 per cent and trips to emergency departments by 11 per cent. Hospitalizations for asthma decreased by 19 per cent.

WHO
Findings of the Study indicate almost immediate and substantial effects on health outcomes followed reduced exposure to air pollution. It’s critical that governments adopt and enforce WHO guidelines for air pollution immediately. Wikimedia Commons

Similarly, when China imposed factory and travel restrictions for the Beijing Olympics, lung function improved within two months, with fewer asthma-related physician visits and less cardiovascular mortality.

“Fortunately, reducing air pollution can result in prompt and substantial health gains. Sweeping policies affecting a whole country can reduce all-cause mortality within weeks,” Schraufnagel said.

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Local programmes, such as reducing traffic, have also promptly improved many health measures, said the study. (IANS)