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The colour of our eyes or the straightness of our hair is linked to our DNA, but the development of Alzheimer’s disease isn’t exclusively linked to Genetics, suggest new research.
In the first study published about Alzheimer’s disease among identical triplets, researchers found that despite sharing the same DNA, two of the triplets developed Alzheimer’s while one did not.
The two triplets that developed Alzheimer’s were diagnosed in their mid-70s, said the paper published in the journal Brain.
“These findings show that your genetic code doesn’t dictate whether you are guaranteed to develop Alzheimer’s,” said Dr Morris Freedman, head of neurology at Baycrest Centre for Geriatric Care.
“There is hope for people who have a strong family history of dementia since there are other factors, whether it’s the environment or lifestyle, we don’t know what it is, which could either protect against or accelerate dementia.”
All three, 85-year-old siblings had hypertension, but the two with Alzheimer’s had long-standing, obsessive-compulsive behaviour.
The research team analyzed the gene sequence and the biological age of the body’s cells from blood that was taken from each of the triplets, as well as the children of one of the triplet’s with Alzheimer’s.
Among the children, one developed early onset Alzheimer’s disease at age 50 and the other did not report signs of dementia.
The research team also discovered that although the triplets were octogenarians at the time of the study, the biological age of their cells was six to ten years younger than their chronological age.
In contrast, one of the triplet’s children, who developed early onset Alzheimer’s, had a biological age that was nine years older than the chronological age.
The other child, who did not have dementia, of the same triplet showed a biological age that was close to their actual age.
“The latest genetics research is finding that the DNA we die with isn’t necessarily what we received as a baby, which could relate to why two of the triplets developed Alzheimer’s and one didn’t,” says Dr. Ekaterina Rogaeva, senior author on the paper and researcher at the University of Toronto’s Tanz Centre for Research in Neurodegenerative Diseases.
“As we age, our DNA ages with us and as a result, some cells could mutate and change over time”.
With additional funding, researchers could further explore the interaction between genetics and environment in the development of Alzheimer’s disease and the impact of environmental factors in delaying the onset of this disorder. (IANS)
Facebook must pay a $4.75 million fine and up to $9.5 million in back pay to eligible victims who say the company discriminated against U.S. workers in favor of foreign ones, the Justice Department announced Tuesday.
The discrimination took place from at least January 1, 2018, until at least September 18, 2019.
The Justice Department said Facebook "routinely refused" to recruit or consider U.S. workers, including U.S. citizens and nationals, asylees, refugees and lawful permanent residents, in favor of temporary visa holders. Facebook also helped the visa holders get their green cards, which allowed them to work permanently
In a separate settlement, the company also agreed to train its employees in anti-discrimination rules and conduct wider searches to fill jobs.
The fines and back pay are the largest civil awards ever given by the DOJ's civil rights division in its 35-year history.
"Facebook is not above the law and must comply with our nation's civil rights laws," Assistant Attorney General Kristen Clarke told reporters in a telephone conference.
"While we strongly believe we met the federal government's standards in our permanent labor certification [PERM] practices, we've reached agreements to end the ongoing litigation and move forward with our PERM program, which is an important part of our overall immigration program," a Facebook spokesperson said in a statement. "These resolutions will enable us to continue our focus on hiring the best builders from both the U.S. and around the world and supporting our internal community of highly skilled visa holders who are seeking permanent residence." (VOA/RN)
Keywords: Facebook, Employment, Justice Dept., Recruitment
Tomatoes are a staple in the Indian diet, be it a vegetarian or a non-vegetarian dish. It has to be a part of each meal in some form. As puree, paste, flavour, or diced into the dal. This tangy, sweet, and juicy ingredient was not always Indian. In fact, it did not even grow in India until the British sanctioned it. It is a product of colonization and has come a long way to become part of our everyday meals.
Originally, the tomato was considered poison. Its actual native is debatable. Some say it is European while others argue that is came from indigenous parts of Spain and Portugal. Either way, it is a plant species that is associated with the legendary Nightshade. It looks very similar to this poisonous plant that tomatoes were not even harvested for a long time, for fear of picking Nightshade instead. It was believed that Nightshade caused the blood to turn to acid and that tomatoes had the same property. Later research proved that the plant itself may be poisonous but the fruit is not.
The fruit if the woody nightshade plant Image source: Wikimedia Commons
Tomato is considered a fruit instead of a vegetable because it is cooked. But this theory has an interesting tale behind it. in the United States, in 1887, a tax was levied on the transport of vegetables, but not on fruits. By then, tomatoes had become a huge part of the American diet and traders could not afford to pay the ten percent duty. So, they began to call the large loads they transported fruits, just to avoid the tax due. In time, this is how the tomato came to be regarded. Some scientists went even further and stated that it is a berry. Botanists claim that since it is a part that grows from the flower's ovary and contains seeds, it is a fruit and not a vegetable. But this is a debate that will never end.
Incorporating tomatoes into the Indian diet must have happened so long ago that people do not remember a time without tomatoes, considering how it is the fundamental ingredient of most cuisines. The tomato has a name in every language as well, so the trading between nations, the voyages that brought them to India, and the decoding of the fruit-vegetable must have taken place far earlier than our ancestors remember. Or, perhaps we liked it so much that we decided to use it everywhere and make it our own. Nonetheless, it has been a delightful addition.
Keywords: Tomato, Fruit, Vegetable, Nightshade, Voyage, Staple
Every child who grew up in the 90s and the early 00s has certainly grown up around Tom and Jerry, the adorable, infamous cat-chases-mouse cartoon. The idea of naughtiness and playing mischief had the standards that this particular series set for children and defined how much wreckage was funny enough.
The show's creators, William Hanna and Joseph Barbera initially named their characters Jasper and Jinx. They did not plan for the fame that Tom and Jerry brought them when they released a movie by the name of "Puss Gets the Boot". This movie featured a certain cat and mouse who were a notorious pair, named Jasper and Jinx. When the movie became a hit, the names of the characters were changed and the show shot to fame.
Tom and Jerry became a go-to cartoon for children in the early 00s, and it was one of those shows with a firm foundation, that had already been in the running for decades. The original template had been planned nearly 80 years ago, and the makers did not change it. The music that was played in the many episodes, made a breakthrough in its own way. It is the most easily recognizable melody with utterly nostalgic associations.
Today, Tom and Jerry is still a household name in homes where children love cartoons Image credit: wikimedia commons
A set of supporting characters were defined for the show, to occasionally take the focus off the original pair. There was a large, black woman named Mammy Two Shoes and a bulldog who took Jerry's side. Mammy Two Shoes was discontinued because her character portrayed racist tendencies. A tall white woman replaced her, who was kinder and loved mice. Either of the women's faces was never revealed.
Today, Tom and Jerry is still a household name in homes where children love cartoons. There are a host of other shows besides this that aim to replicate the same aspects of the cartoon but do not come close at all. Despite the immense amount of violence in the show, it is a beloved pastime of parents and children alike.
Keywords: Tom and Jerry, Cartoon, Hanna and Barbera, Television