Tuesday January 28, 2020

Development of Alzheimer’s Disease Not Totally Linked to Genetics: Study

The research team analyzed the gene sequence and the biological age of the body's cells from blood

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Genetics
With additional funding, researchers could further explore the interaction between Genetics and environment in the development of Alzheimer's disease and the impact of environmental factors in delaying the onset of this disorder. Pixabay

The colour of our eyes or the straightness of our hair is linked to our DNA, but the development of Alzheimer’s disease isn’t exclusively linked to Genetics, suggest new research.

In the first study published about Alzheimer’s disease among identical triplets, researchers found that despite sharing the same DNA, two of the triplets developed Alzheimer’s while one did not.

The two triplets that developed Alzheimer’s were diagnosed in their mid-70s, said the paper published in the journal Brain.

“These findings show that your genetic code doesn’t dictate whether you are guaranteed to develop Alzheimer’s,” said Dr Morris Freedman, head of neurology at Baycrest Centre for Geriatric Care.

“There is hope for people who have a strong family history of dementia since there are other factors, whether it’s the environment or lifestyle, we don’t know what it is, which could either protect against or accelerate dementia.”

All three, 85-year-old siblings had hypertension, but the two with Alzheimer’s had long-standing, obsessive-compulsive behaviour.

The research team analyzed the gene sequence and the biological age of the body’s cells from blood that was taken from each of the triplets, as well as the children of one of the triplet’s with Alzheimer’s.

Genetics
The colour of our eyes or the straightness of our hair is linked to our DNA, but the development of Alzheimer’s disease isn’t exclusively linked to Genetics, suggest new research. Pixabay

Among the children, one developed early onset Alzheimer’s disease at age 50 and the other did not report signs of dementia.

The research team also discovered that although the triplets were octogenarians at the time of the study, the biological age of their cells was six to ten years younger than their chronological age.

In contrast, one of the triplet’s children, who developed early onset Alzheimer’s, had a biological age that was nine years older than the chronological age.

The other child, who did not have dementia, of the same triplet showed a biological age that was close to their actual age.

Genetic
Your Genetic code doesn’t dictate whether you are guaranteed to develop Alzheimer’s Disease. Pixabay

“The latest genetics research is finding that the DNA we die with isn’t necessarily what we received as a baby, which could relate to why two of the triplets developed Alzheimer’s and one didn’t,” says Dr. Ekaterina Rogaeva, senior author on the paper and researcher at the University of Toronto’s Tanz Centre for Research in Neurodegenerative Diseases.

“As we age, our DNA ages with us and as a result, some cells could mutate and change over time”.

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With additional funding, researchers could further explore the interaction between genetics and environment in the development of Alzheimer’s disease and the impact of environmental factors in delaying the onset of this disorder. (IANS)

Next Story

Children of Mothers With Diabetes Are Likely To Suffer From Heart Diseases, Says Study

The researchers also found higher rates for specific types of CVD children of mothers with diabetes

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Diabetes
Diabetes was categorised as pregestational (before pregnancy) or gestational (during pregnancy) and women with diabetic complications were identified in the Study. Pixabay

Children of mothers with diabetes have increased rates of early onset cardiovascular disease or CVD (conditions affecting the heart or blood vessels) from childhood up to the age of 40, the researchers have warned.

The increased rates were more pronounced among children of mothers with a history of CVD or diabetic complications, said the study published in the journal The BMJ.

“Our study provides evidence that children of mothers with diabetes, especially those with a history of CVD or with diabetic complications, had increased rates of early onset CVD throughout the early decades of life,” said study researchers from Aarhus University in Denmark.

If this association is shown to be causal, preventing, screening, and treating diabetes in women of childbearing age could be important not only for improving the health of the women but also for reducing long term risks of CVD in their offspring, the researchers added

The number of women diagnosed with diabetes before or during pregnancy has increased globally, and children of these women are more likely to have risk factors for future CVD, such as high blood pressure and high blood sugar levels. It is unclear, however, whether or to what extent exposure to diabetes in the womb increases the risk of developing CVD in offspring over a lifetime.

So an international team of researchers set out to evaluate associations between diabetes diagnosed before or during pregnancy and early onset CVD in children during their first four decades of life. They base their findings on national registry data for over 2.4 million children born without congenital heart disease in Denmark from 1977 to 2016.

Diabetes was categorised as pregestational (before pregnancy) or gestational (during pregnancy) and women with diabetic complications were identified.

Diabetes
Children of mothers with diabetes have increased rates of early onset cardiovascular disease or CVD (conditions affecting the heart or blood vessels) from childhood up to the age of 40, the researchers have warned. Pixabay

Other potentially influential factors, such as mother’s age, education, lifestyle and medical history were also taken into account. During up to 40 years of follow-up, children of mothers with diabetes had a 29 per cent increased overall rate of early onset CVD compared with children of mothers who did not have diabetes (cumulative risks: 17.8 per cent vs 13.1 per cent ).

The researchers also found higher rates for specific types of CVD children of mothers with diabetes, particularly heart failure (45 per cent), hypertensive disease (78 per cent), deep vein thrombosis (82 per cent), and pulmonary embolism (91 per cent).

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Increased rates were seen in each age group in childhood (before 20 years of age) and early adulthood (from 20 to 40 years of age), regardless of the type of diabetes they were exposed to (pregestational or gestational) and rates were similar for both type 1 and type 2 diabetes, the study said. (IANS)