Tuesday, August 11, 2020
Home Life Style Health & Fitness Alzheimer's Drug Holds Promise For Rare Neurological Disease, Suggest Researchers

Alzheimer’s Drug Holds Promise For Rare Neurological Disease, Suggest Researchers

In Alzheimer's, brain regions controlling memory are attacked first

An existing therapy frequently used to reduce symptoms of Alzheimer’s disease might work on patients with a rare neurological disease that destroys language and currently has no treatment, suggest researchers.

Alzheimer’s patients are presently treated with a class of drugs called cholinesterase inhibitors which reduce its symptoms by preventing the breakdown of acetylcholine — a chemical messenger that contributes to learning and memory.

The study, led by Northwestern University researchers, found that individuals with Primary Progressive Aphasia (PPA) undergo the same loss of cholinergic neurons and axons in the forebrain as individuals with Alzheimer’s. Therefore, they might also benefit from these cholinesterase inhibitors.

The team focused on the type of PPA that shows a typical Alzheimer’s pathology — the plaques and tangles — in the brain.

However, these patients tend to be excluded from Alzheimer’s-related clinical trials and are less likely to be prescribed cholinesterase inhibitors.

“That’s why our study is so important for patients,” said Changiz Geula from the varsity.

"The question for us now is not how to eliminate cholesterol from the brain, but about how to control cholesterol's role in Alzheimer's disease through the regulation of its interaction with amyloid-beta," Vendruscolo said.
In Alzheimer’s disease, patients start losing memory. Pixabay

No one knew before that this cholinergic system is destroyed in patients with PPA associated with Alzheimer’s but we’ve now demonstrated that and have justified the need for clinical trials with this therapy, the researchers said.

“The findings provide the basic scientific foundation to spur a clinical trial to test the treatment on patients with PPA,” Geula said.

The study, reported in the Neurology journal, noted that chemical brain scans called positron emission tomography (PET) can determine if there is Alzheimer’s disease pathology in someone’s brain while they are alive.

Also Read- Vitamin D May Help to Combat Multi-drug Resistant Tuberculosis

This makes it possible to see if someone has the type of PPA associated with Alzheimer’s disease or not.

In individuals with PPA, brain regions responsible for language, located in the left hemisphere in the majority of the population, are damaged first.

Patients with PPA progressively continue to lose their ability to talk, read, write or understand what they hear. In Alzheimer’s, brain regions controlling memory are attacked first. (IANS)

STAY CONNECTED

18,960FansLike
362FollowersFollow
1,781FollowersFollow

Most Popular

Actress Madhuri Dixit Shares Her Bollywood Journey With Fans

Actress Madhuri Dixit-Nene went down memory lane and shared how she was bitten by the acting bug. "This day back in 1984 I started my...

This Survey Reveals India’s “Consciousness” Towards Diet and Nutrition

As many as 97 percent Indians are aware of the essential nutrients and micro-nutrients required for their body, of which 60 percent 'rarely' or...

Heavy Cigarette Smoking Leads To Complex Health Issues: Study

Each cigarette smoked a day by heavy smokers increases the risk of contracting several diseases by more than 30 per cent, warn researchers. The study,...

“I Believe in Repeating Clothes”, Says B-Town Actress Bhumi Pednekar

Actress Bhumi Pednekar believes in repeating her clothes. She adds that she also believes in sharing her wardrobe with her sister. "I believe in repeating...

Reliving The Life Of Abanindranath Tagore

A founding artist of the Bengal school of art, Abanindranath Tagore (1871-1951) has had a profound impact on modern Indian art as we know...

Boost Immunity This Monsoon: The Tasty Way

2020 is unlike any year we have seen and in parts of the country this monsoon is unlike any we have seen. Staying healthy is...

Kohli, Rohit, Dhoni Among Most Popular Cricketers Worldwide: Study

India skipper Virat Kohli's popularity knows no bounds and once again it has been re-affirmed by a study which has revealed that the 31-year-old...

I Have Always been a Hands-on Mom: Raveena Tandon

By Puja Gupta A hands-on mom, Raveena Tandon has not just portrayed impactful and memorable characters in her career spanning over two decades but has...

Recent Comments