Saturday January 25, 2020

Chinese Alzheimer’s Drug to Undergo Global Clinical Trials

In the last test, a total of 818 participants from 34 leading hospitals in China took 450 mg GV-971 orally twice a day for a treatment period of nine months, which proved safe and effective in improving cognition

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In Alzheimer's disease, patients start losing memory. Pixabay

An innovative Chinese Alzheimer’s drug extracted from brown algae is set to go through clinical trials on 2,000 patients overseas this year.

The orally administered drug GV-971 will be tested in 200 clinical centers in North America, the European Union, Eastern Europe, Asia Pacific and other places, according to Green Valley Pharmaceutical Company, one of the drug’s co-developers.

China has already approved the drug.

Green Valley Pharmaceutical will complete the global clinical trials in 2024 and submit the New Drug Application to the US Food and Drug Administration and European Medicines Agency in 2025, Xinhua reported.

GV-971 was jointly developed by the Shanghai Institute of Materia Medica under the Chinese Academy of Sciences (CAS), Ocean University of China and Green Valley, after a 22-year study.

Alzheimer's
A lady suffering from Alzheimer’s. Flickr

The results of the mechanism of action study were published in the international journal Cell Research in September 2019, saying that the drug works by modifying gut bacteria to ultimately reduce brain inflammation in mice that were genetically engineered to have the disease.

It was approved for marketing last November by China’s National Medical Products Administration, which said the GV-971 “can improve cognition in patients with mild to moderate Alzheimer’s disease (AD).”

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According to researchers, apart from animal experiments, more than 1,100 Chinese Alzheimer’s disease patients participated in clinical trials before the drug hit the market.

In the last test, a total of 818 participants from 34 leading hospitals in China took 450 mg GV-971 orally twice a day for a treatment period of nine months, which proved safe and effective in improving cognition.

“Because of its effectiveness on Chinese patients, we expect this drug to benefit more people in the rest of the world,” said Lyu Songtao, Chairman of the Shanghai-based pharmaceutical company. (IANS)

Next Story

Chinese Researchers Spot Monster Black Hole Bigger Than Sun

Chinese team spots monster black hole which is 70 times bigger than Sun

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Black Hole
A team of Chinese scientists spotted a black hole that is 70 times larger than the sun. (Representational Image Only). Wikimedia Commons

A team led by Chinese researchers has spotted a monster black hole with a mass 70 times greater than Sun — toppling the earlier assumption that the mass of an individual black hole in our Galaxy is no more than 20 times that of Sun.

Our Milky Way Galaxy is estimated to contain 100 million stellar black holes — cosmic bodies formed by the collapse of massive stars and so dense even light can’t escape.

The team, headed by Professor LIU Jifeng of the National Astronomical Observatory of China of the Chinese Academy of Sciences (NAOC), spotted a stellar black hole with a mass 70 times greater than the Sun.

The monster black hole is located 15 thousand light-years from Earth and has been named “LB-1” by the researchers in a paper reported in the journal Nature.

“Black holes of such mass should not even exist in our Galaxy, according to most of the current models of stellar evolution,” said LIU.

“We thought that very massive stars with the chemical composition typical of our Galaxy must shed most of their gas in powerful stellar winds, as they approach the end of their life. Therefore, they should not leave behind such a massive remnant,” he explained.

Spotting black hole
The monster black hole is located 15 thousand light-years from Earth. (Representational Image Only). Wikimedia Commons

Until just a few years ago, stellar black holes could only be discovered when they gobbled up gas from a companion star.

The vast majority of stellar black holes in our Galaxy are not engaged in a cosmic banquet, though, and thus don’t emit revealing X-rays.

As a result, only about two dozen Galactic stellar black holes have been well identified and measured.

To counter this limitation, LIU and collaborators surveyed the sky with China’s Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST).

After the initial discovery, the world’s largest optical telescopes – Spain’s 10.4-m Gran Telescopio Canarias and the 10-m Keck I telescope in the US – were used to determine the system’s physical parameters.
The results were nothing short of fantastic: a star eight times heavier than the Sun was seen orbiting a 70-solar-mass black hole, every 79 days.

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The direct sighting of LB-1 proves that this population of over-massive stellar black holes exists even in our own backyard.

“This discovery forces us to re-examine our models of how stellar-mass black holes form,” said LIGO Director Professor David Reitze from University of Florida in the US. (IANS)

One response to “Chinese Researchers Spot Monster Black Hole Bigger Than Sun”

  1. The designer of this awe-inspiring universe has many many surprises ‘up his sleeve.’ Scientists will yet discover more and more amazing revelations as they research and study our unfathomable ‘miracle’ called the universe. The ancient scriptures says: Look! These are just the fringes of his ways;Only a faint whisper has been heard of him! So who can understand his mighty thunder?”