Saturday December 7, 2019

Anaemia Drug Can Aid in Recovery After Heart Attack

However, further studies will be needed to confirm if the same benefits are seen in humans, they noted

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Cholesterol
Lead, mercury exposure raises cholesterol levels: Study. Pixabay

Drugs currently undergoing development to treat anaemia — lack of blood — could be repurposed to help prevent people with Type-2 diabetes from developing heart failure, according to a new research.

Researchers found that after a heart attack, a protein called HIF acts to help heart cells survive.

In people with diabetes, fats accumulate within the heart muscle and stop the HIF protein from becoming active. This means that a person is more likely to suffer lasting heart muscle damage, and develop heart failure after a heart attack.

“After a heart attack, people with Type-2 diabetes are more likely to develop heart failure more quickly, but we have not fully understood the reasons why that is the case,” said lead researcher Lisa Heather, research student at the University of Oxford in the UK.

“What we have shown with this research is that the metabolism of people with Type-2 diabetes means they have higher levels of fatty acids in the heart. This prevents signals going to the heart protective protein telling it to ‘kick-in’ after a heart attack,” she added.

Representational image.
Representational image. (IANS)

In the study, published in the Journal of the American College of Cardiology, the team treated diabetic rats with a drug known to activate the HIF protein, and were able to encourage the heart to recover after a heart attack.

However, these initial results suggest that several drugs known to activate HIF and currently undergoing phase-III clinical trials to treat people with anaemia, could potentially be given to people with diabetes, immediately after a heart attack in the future, the researchers said.

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“This research in rats has not only identified the mechanism that could explain why people with Type-2 diabetes have poorer outcomes after a heart attack, but also a practical way this might be prevented,” the researchers explained.

However, further studies will be needed to confirm if the same benefits are seen in humans, they noted. (IANS)

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Here’s How Proper Sleep Can Help in Reducing Suicidal Thoughts

The frequency and intensity of disturbing dreams or nightmares, also a factor in insomnia-associated suicide

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Suicidal Thoughts
The sleep aid given to people is most effective in reducing Suicidal Thoughts in patients with the most severe insomnia. Pixabay

 Insomnia is a driver of suicide, and people with severe insomnia may safely benefit from taking a sedative to help address their sleep problems as it reduces their Suicidal Thoughts, a new study suggests.

The study, published in The American Journal of Psychiatry, included 103 participants aged 18 to 65 with major depressive disorder, insomnia and suicidal thoughts.

All participants took an antidepressant for the eight-week duration of the trial and half also took the sedative-hypnotic zolpidem at bedtime.

“While the results do not argue for the routine prescription of hypnotics for mitigating suicidal ideation in all depressed outpatients with insomnia, they suggest that co-presciption of a hypnotic during initiation of an antidepressant may be beneficial in suicidal outpatients, especially in patients with severe insomnia,” said study researchers from Augusta University in the US.

During the study, participants completed regular self-reports of the severity of their insomnia and completed a daily sleep diary during their treatment that included details like how many times they woke up during the night and how long they actually slept.

Researchers also measured distorted thoughts about sleep, like participants thinking they would never again have a good night’s sleep.

The frequency and intensity of disturbing dreams or nightmares, also a factor in insomnia-associated suicide, also were measured.

Patients wore a wrist device to keep up with rest/activity cycles.

Those taking the sleep aid showed both significant immediate and longer-term improvement in their reported insomnia severity.

Suicidal Thoughts
Insomnia is a driver of suicide, and people with severe insomnia may safely benefit from taking a sedative to help address their sleep problems as it reduces their Suicidal Thoughts. Pixabay

While both groups reported significant improvement in their feelings about hopelessness, quality of life, nightmares and dysfunctional beliefs about sleep, as well as related insomnia and suicidality, the group taking the sleep aid had a greater reduction in suicidal thinking.

The sleep aid was most effective in reducing suicidal thoughts in patients with the most severe insomnia.

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There were no deaths or suicide attempts by participants during the course of the study.

Two weeks after the study concluded both study groups — including those not taking the sleep aid — appeared to have maintained progress with reduced depression scores and suicidal thoughts. (IANS)