Saturday April 20, 2019

Antibiotics Most Frequently Prescribed Medicine Worldwide

Considering most countries have laws prohibiting over-the-counter sales of antibiotics, there is a need to ensure such laws are more strictly enforced where appropriate

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The study found that between 2000 and 2010, the consumption of antibiotics increased globally from 50 billion to 70 billion standard units.
The study found that between 2000 and 2010, the consumption of antibiotics increased globally from 50 billion to 70 billion standard units. (IANS)

The increased over-the-counter supply of antibiotics in many countries including India, is worsening antibiotic resistance globally, finds a study highlighting an urgent need for better enforcement of laws.

The study found that between 2000 and 2010, the consumption of antibiotics increased globally from 50 billion to 70 billion standard units.

A majority of overall increase occurred in India, China, Brazil, Russia and South Africa.

“This overuse of antibiotics could facilitate the development and spread of antibiotic resistance. In India, for example, about 57,000 neonatal sepsis deaths occurring annually are due to antibiotic-resistant infections,” said Emmanuel Adewuyi, from the Queensland University of Technology in Australia.

It accounts for more than two million infections and 23,000 deaths annually in the US, and around 25,000 deaths in Europe each year.

A majority of overall increase occurred in India, China, Brazil, Russia and South Africa.
A majority of overall increase occurred in India, China, Brazil, Russia and South Africa. (IANS)

“Reliable estimates of the burden of antibiotic-resistant infections in developing countries are lacking but it is believed to cause many more deaths in these countries,” Adewuyi added.

For the study, published in The Journal of Infection, the team analysed studies from 24 countries.

The study found that antibiotics supplied without prescription were largely for the treatment of acute and self-limited conditions such as upper respiratory tract infections and gastroenteritis.

Also Read: Oral Antibiotics Possess Threat of Kidney Stones

“Many were also broad-spectrum antibiotics like amoxicillin, azithromycin and others which increase the risk of development of difficult-to-treat infections like the deadly methicillin resistant Staphylococcus aureus,” Adewuyi said.

“Such practice not only predisposes patients to inappropriate drug and dose choices, it portends great risks for the development and spread of resistant organisms, masking of diagnosis as well as delayed hospital admissions,” said Asa Auta from the University of Central Lancashire in Britain.

“Considering most countries have laws prohibiting over-the-counter sales of antibiotics, there is a need to ensure such laws are more strictly enforced where appropriate,” Adewuyi noted. (IANS)

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Chilli Can Serve As A Valuable Medicine in Case of Lung Cancer

Additional experiments revealed capsaicin suppresses lung cancer metastasis by inhibiting activation of the protein Src. This protein plays a role in the signalling that controls cellular processes like proliferation, differentiation, motility and adhesion.

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In experiments involving three lines of cultured human non-small cell lung cancer cells, researchers observed capsaicin inhibited invasion, the first step of the metastatic process. Pixabay

Besides spicing up your food, chilli, it seems, also has some medicinal value. New research suggests the compound responsible for chilli’s heat could help slow the spread of lung cancer, the leading cause of cancer death for both men and women.

Most cancer-related deaths occur when cancer spreads to distant sites, a process called metastasis.

“Lung cancer and other cancers commonly metastasise to secondary locations like the brain, liver or bone, making them difficult to treat,” said one of the study authors Jamie Friedman from Marshall University in the US.

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They also found mice with metastatic cancer that consumed capsaicin showed smaller areas of metastatic cancer cells in the lung compared with mice not receiving the treatment. Pixabay

“Our study suggests the natural compound capsaicin from chilli peppers could represent a novel therapy to combat metastasis in lung cancer patients,” said Friedman, a doctoral candidate who performed the research in the laboratory of Piyali Dasgupta at Marshall University Joan C. Edwards School of Medicine.

In experiments involving three lines of cultured human non-small cell lung cancer cells, researchers observed capsaicin inhibited invasion, the first step of the metastatic process.

They also found mice with metastatic cancer that consumed capsaicin showed smaller areas of metastatic cancer cells in the lung compared with mice not receiving the treatment.

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Most cancer-related deaths occur when cancer spreads to distant sites, a process called metastasis. Pixabay

The findings were presented during the 2019 Experimental Biology meeting being held from April 6-9 in Orlando, Florida.

Also Read:Facebook Sends Its Representatives To Users’ Home in India, To Check Authenticity of Posts
Additional experiments revealed capsaicin suppresses lung cancer metastasis by inhibiting activation of the protein Src. This protein plays a role in the signalling that controls cellular processes like proliferation, differentiation, motility and adhesion.

“We hope one day capsaicin can be used in combination with other chemotherapeutics to treat a variety of lung cancers,” said Friedman. (IANS)