Monday March 18, 2019

Commonly Used Antidepressant Can Help Delay Ageing of Brain Cells, Says Study

In the new study, appearing in the Journal of Neuroscience, they put the drug in the drinking water of mice at various ages for various amounts of time

0
//
Aspirin
Aspirin may lower risk of ovarian cancer. Pixabay

Administering commonly used antidepressant fluoxetine to mice helped restore youthful flexibility to their ageing brain cells, showed a study.

The study provides fresh evidence that the decline in the capacity of brain cells to change, called “plasticity,” rather than a decline in total cell numbers may underlie some of the sensory and cognitive declines associated with normal brain ageing.

Scientists at the MIT revealed that in mice treated with fluoxetine, also known as Prozac, the inhibitory interneurons in the visual cortex remained just as abundant during ageing, but their arbors become simplified and they become much less structurally dynamic and flexible.

They could also restore a significant degree of lost plasticity to the cells.

“Here we show that fluoxetine can also ameliorate the age-related decline in structural and functional plasticity of visual cortex neurons,” said the scientists including lead author Ronen Eavri from MIT.

antidepressant
Administering commonly used antidepressant fluoxetine to mice helped restore youthful flexibility to their ageing brain cells.
 “Our finding that fluoxetine treatment in ageing mice can attenuate the concurrent age-related declines in interneuron structural and visual cortex functional plasticity suggests it could provide an important therapeutic approach towards mitigation of sensory and cognitive deficits associated with ageing, provided it is initiated before severe network deterioration,” they added.

A previous study had shown that fluoxetine promotes interneuron branch remodelling in young mice, so the team decided to see whether it could do so for older mice and restore plasticity as well.

In the new study, appearing in the Journal of Neuroscience, they put the drug in the drinking water of mice at various ages for various amounts of time.

Also Read- Farhan Akhtar urges West Bengal to Correct a ‘Glaring Error’

Three-month-old mice treated for three months showed little change in dendrite growth compared to untreated controls, but 25 per cent of the cells in six-month-old mice treated for three months showed significant new growth (at the age of 9 months).

But among 3-month-old mice treated for six months, 67 per cent of cells showed new growth by the age of 9 months, showing that treatment starting early and lasting for six months had the strongest effect. (IANS)

Next Story

Researchers Discover Novel Drug to Delay Ageing

Besides, the blood chemistry of the mice that underwent drug treatment was also found to have no adverse effects as it was similar to the untreated mice

0
Go Makeup Free Once a Week to Delay Ageing
Go Makeup Free Once a Week to Delay Ageing. (Wikimedia commons)

Researchers, including one of Indian origin, have developed a new drug that can delay ageing demonstrated by declining muscle mass, strength and function.

As human bodies age, they increasingly lose the ability to repair and rebuild degenerating skeletal muscles. This can dramatically limit the ability of older adults to live fully active and independent lives.

In the study, researchers from the University of Texas Medical Branch (UTMB) at Galveston identified a protein called Nicotinamide N-methyltransferase (NNMT) in muscle stem cells that appears to be responsible for the age-related dysfunction.

They developed a small molecule drug, NNMT inhibitor (NNMTi), which when prescribed to aged mice could limit NNMT’s effects as well as significantly increase muscle size, strength and metabolic state in the animals.

By resetting muscle stem cells to a more youthful state, the mice could be rejuvenated so that they could more effectively repair muscle tissues, the researchers explained.

“There are no treatments currently available to delay, arrest or reverse age-related muscle degeneration,” said Harshini Neelakantan, research scientist at UTMB.

Makeup can speed up the process of ageing.
Slow down skin ageing by this drug. Pixabay

“These initial results support the development of an innovative drug treatment that has the potential to help the elderly to become fitter, faster and stronger, thus enabling them to live more active and independent lives as they age,” she added.

For the study, published in Biochemical Pharmacology, the team treated ageing mice, suffering from muscle injury, with the drug or a placebo.

Following seven days of treatment, researchers saw that the aged mice, which received the drug, had more functional muscle stem cells than the placebo mice.

Also Read- Social Media Giant Facebook Accused of Revealing Sensitive Health Data

Moreover, the size of the muscle fibres doubled and the strength also increased significantly.

Besides, the blood chemistry of the mice that underwent drug treatment was also found to have no adverse effects as it was similar to the untreated mice. (IANS)