Thursday February 27, 2020

Antidepressants are linked to high risk of dementia: Study

For the study, published in the journal BMJ, an international team from the US, UK and Ireland analysed more than 27 million prescriptions as recorded in the medical records of 40,770 patients over age 65 diagnosed with dementia compared to the records of 283,933 older adults without dementia.

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However, the researchers are yet not aware of
Representational Image, Pixabay

If you are used to taking commonly prescribed antidepressants, think twice. According to a study, you may be at high risk of developing dementia, even 20 years before the actual diagnosis, a study has warned.

The researchers found greater incidence of dementia among patients prescribed anticholinergic antidepressants, anticholinergic bladder medications as well as anticholinergic Parkinson’s disease medications than among older adults who were not prescribed these drugs.

“Anticholinergics, medications that block acetylcholine, a nervous system neurotransmitter, have previously been implicated as a potential cause of cognitive impairment,” said Noll Campbell, assistant professor at the Purdue University in Indiana.

However, the researchers are yet not aware of "exactly how anticholinergics might cause dementia", the researchers said.
Representational Image- dementia, Pixabay

However, the researchers are yet not aware of “exactly how anticholinergics might cause dementia”, the researchers said.

For the study, published in the journal BMJ, an international team from the US, UK and Ireland analysed more than 27 million prescriptions as recorded in the medical records of 40,770 patients over age 65 diagnosed with dementia compared to the records of 283,933 older adults without dementia.

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“The findings make it clear that clinicians need to carefully consider the anticholinergic burden of their patients and weigh other options,” said Malaz Boustani, from the US-based Regenstrief Institute.

“Physicians should review all the anticholinergic medications – including over-the-counter drugs – that patients of all ages are taking and determine safe ways to take individuals off anticholinergic medications in the interest of preserving brain health,” Boustani said. (IANS)

 

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Taller Men Are at a Lower Risk of Dementia in Old Age: Study

Taller men may have lower dementia risk in old age

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Men who are taller in young adulthood may have a lower risk of dementia in old age. Pixabay

Men who are taller in young adulthood may have a lower risk of dementia in old age, according to a new health news and research.

Previous studies have suggested that height may be a risk factor for dementia, but much of this research was not able to take into account genetic, environmental, or other early-life factors that may be linked to both height and dementia.

“We wanted to see if body height in young men is associated with diagnosis of dementia, while exploring whether intelligence test scores, educational level, and underlying environmental and genetic factors shared by brothers explain the relationship,” said lead author Terese Sara Hoj Jorgensen from University of Copenhagen in Denmark.

For the findings, published in the journal eLife, researchers analysed data on 666,333 Danish men born between 1939 and 1959, including 70,608 brothers and 7,388 twins, from Danish national registries.

dementia
Previous studies have suggested that height may be a risk factor for dementia, but much of this research was not able to take into account genetic, environmental, or other early-life factors. Pixabay

They found a total of 10,599 men who developed dementia later in life.

Their adjusted analysis of this group showed that there was about a 10 per cent reduction in the risk of developing dementia for about every 6cm of height in individuals above the average height.

When the team took into account the potential role of intelligence or education, the unadjusted relationship between height and dementia risk was only slightly reduced.

They found that the relationship between height and dementia also existed when they looked at brothers with different heights, suggesting that genetics and family characteristics alone do not explain why shorter men had a greater dementia risk.

“A key strength of our study is that it adjusted for the potential role of education and intelligence in young men’s dementia risk, both of which may build up cognitive reserve and make this group less vulnerable to developing dementia,” said study senior author Merete Osler.

‘Cognitive reserve’ refers to the brain’s ability to improvise and solve problems that come up in everyday life.

Adjusting for education and intelligence reduces the likelihood that the relationship between height and dementia is really explained by cognitive reserve, the researchers said.

“Together, our results point to an association between taller body height in young men and a lower risk of dementia diagnosis later in life, which persists even when adjusted for educational level and intelligence test scores,” Osler said.

Also Read- Aging Women Likely to Consume More Alcohol: Study

“Our analysis of the data concerning brothers confirms these findings, and suggests the association may have common roots in early-life environmental exposures that are not related to family factors shared by brothers,” she added. (IANS)