Friday November 16, 2018

Antidepressants are linked to high risk of dementia: Study

For the study, published in the journal BMJ, an international team from the US, UK and Ireland analysed more than 27 million prescriptions as recorded in the medical records of 40,770 patients over age 65 diagnosed with dementia compared to the records of 283,933 older adults without dementia.

0
//
However, the researchers are yet not aware of
Representational Image, Pixabay
Republish
Reprint

If you are used to taking commonly prescribed antidepressants, think twice. According to a study, you may be at high risk of developing dementia, even 20 years before the actual diagnosis, a study has warned.

The researchers found greater incidence of dementia among patients prescribed anticholinergic antidepressants, anticholinergic bladder medications as well as anticholinergic Parkinson’s disease medications than among older adults who were not prescribed these drugs.

“Anticholinergics, medications that block acetylcholine, a nervous system neurotransmitter, have previously been implicated as a potential cause of cognitive impairment,” said Noll Campbell, assistant professor at the Purdue University in Indiana.

However, the researchers are yet not aware of "exactly how anticholinergics might cause dementia", the researchers said.
Representational Image- dementia, Pixabay

However, the researchers are yet not aware of “exactly how anticholinergics might cause dementia”, the researchers said.

For the study, published in the journal BMJ, an international team from the US, UK and Ireland analysed more than 27 million prescriptions as recorded in the medical records of 40,770 patients over age 65 diagnosed with dementia compared to the records of 283,933 older adults without dementia.

Also Read: Essentials Oils For Summer 

“The findings make it clear that clinicians need to carefully consider the anticholinergic burden of their patients and weigh other options,” said Malaz Boustani, from the US-based Regenstrief Institute.

“Physicians should review all the anticholinergic medications – including over-the-counter drugs – that patients of all ages are taking and determine safe ways to take individuals off anticholinergic medications in the interest of preserving brain health,” Boustani said. (IANS)

 

Click here for reuse options!
Copyright 2018 NewsGram

Next Story

Scientists Discover A New Method To Fight Alzheimer’s, Dementia

Worldwide, about seven percent of people over 65 suffer from Alzheimer's or some form of dementia, a percentage that rises to 40 percent above the age of 85.

0
alzheimer's, cholesterol
One hemisphere of a healthy brain (L) is pictured next to one hemisphere of a brain of a person suffering from Alzheimer disease. VOA
Eliminating dead-but-toxic cells occurring naturally in the brains of mice designed to mimic Alzheimer’s slowed neuron damage and memory loss associated with the disease, according to a study published Wednesday that could open a new front in the fight against dementia.The accumulation in the body of “zombie cells” that can no longer divide but still cause harm to other healthy cells, a process called senescence, is common to all mammals.

Scientists have long known that these dead-beat cells gather in regions of the brain linked to old age diseases ranging from osteoarthritis and atherosclerosis to Parkinson’s and dementia.

Prior research had also shown that the elimination of senescent cells in ageing mice extended their healthy lifespan.

But the new results, published in Nature, are the first to demonstrate a cause-and-effect link with a specific disease, Alzheimer’s, the scientists said.

Alzheimer's
A lady suffering from Alzheimer’s. Flickr

But any treatments that might emerge from the research are many years down the road, they cautioned.

In experiments, a team led by Tyler Bussian of the Mayo Clinic in Rochester, Minnesota used mice genetically modified to produce the destructive, cobweb-like tangles of tau protein that form in the neurons of Alzheimer’s patients.

The mice were also programmed to allow for the elimination of “zombie” cells in the same region.

“When senescent cells were removed, we found that the diseased animals retained the ability to form memories, and eliminated signs of inflammation,” said senior author Darren Baker, also from the Mayo Clinic.

The mice likewise failed to develop Alzheimer’s signature protein “tangles”, and retained normal brain mass.

 

Alzheimer's
Alzheimer’s disease patient Isidora Tomaz, 82, sits in an armchair in her house in Lisbon, Portugal. It’s predicted that by 2050, 135 million Americans are going to suffer from mild cognitive impairment, a precursor of Alzheimer’s. VOA

Keeping zombies at bay

A closer look revealed that the “zombies” belonged to a class of cells in the brain and spinal cord, called glia, that provide crucial support and insulation to neurons.

“Preventing the build-up of senescent glia can block the cognitive decline and neuro-degeneration normally experienced by these mice,” Jay Penney and Li-Huei Tsai, both from MIT, wrote in a comment, also in Nature.

Bussian and his team duplicated the results with pharmaceuticals, suggesting that drugs could one day slow or block the emergence of Alzheimer’s by keeping these zombie cells at bay.

“There hasn’t been a new dementia drug in 15 years, so it’s exciting to see the results of this promising study in mice,” said James Pickett, head of research at Alzheimer’s Society in London.

 

Alzheimer's
The accumulation in the body of “zombie cells” that can no longer divide but still cause harm to other healthy cells, a process called senescence, is common to all mammals. IANS

For Lawrence Rajendran, deputy director of the Dementia Research Institute at King’s College London, the findings “open up new vistas for both diagnosis and therapy for neurodegenerative diseases, including Alzheimer’s.”

Up to now, dementia research has been mostly focused on the diseased neurons rather than their neighboring cells.

“It is increasingly becoming clear that other brains cells play a defining role,” Rajendran added.

Several barriers remain before the breakthrough can be translated into a “safe, effective treatment in people,” Pickett and other said.

The elderly often have lots of harmless brain cells that look like the dangerous senescent cells a drug would target, so the molecule would have to be good at telling the two apart.

Also Read: Common Painkillers Triple Harmful Side Effects in Dementia

Worldwide, about seven percent of people over 65 suffer from Alzheimer’s or some form of dementia, a percentage that rises to 40 percent above the age of 85.

The number afflicted is expected to triple by 2050 to 152 million, according to the World Health Organization, posing a huge challenge to healthcare systems. (VOA)