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New Antibody Approach to Tackle Ebola, Research To Make Successful Treatments For The Deadly Viral Infection

Antibodies intended for treatment are normally collected from the blood of people who have survived infection. But they can also be tricky to obtain and carry heightened risks such as potential persistent viruses or other pathogens.

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Ebola
A Congolese health worker administers Ebola vaccine to a boy who had contact with an Ebola sufferer in the village of Mangina, in North Kivu province of the Democratic Republic of Congo, Aug. 18, 2018. VOA

Scientists working on developing vaccines against Ebola have found they can “harvest” antibodies from volunteers vaccinated in research trials and use them to make treatments for the deadly viral infection.

In a study published Tuesday in the journal Cell Reports, the scientists said the approach could be used for Ebola and other newly emerging deadly diseases caused by viruses.

The technique, based on people exposed to the Ebola vaccine but not the Ebola virus itself, suggests protective therapies could be developed from people who are disease-free.

“It is a small, extra step that could lead to new antibody therapies from an increased pool of donors and with reduced risk,” said Alain Townsend, a professor at the MRC Human Immunology Unit at Britain’s Oxford University.

FILE - Health workers treat an unconfirmed Ebola patient inside an Ebola Treatment Center (ETC) in Butembo, Democratic Republic of the Congo, Nov. 3, 2018.
Health workers treat an unconfirmed Ebola patient inside an Ebola Treatment Center (ETC) in Butembo, Democratic Republic of the Congo, Nov. 3, 2018.

He noted that besides Ebola, many experimental vaccines for other life-threatening infections, such as H5N1 and H7N9 bird flu and Middle East Respiratory Syndrome (MERS), are entering clinical trials and could offer similar opportunities for antibodies to be collected.

Ebola is now spreading in Democratic Republic of Congo, where World Health Organization data show at least 676 people have been killed and more than 700 others infected in an outbreak that started eight months ago.

The largest Ebola epidemic in history swept through Sierra Leone, Liberia and Guinea in 2013-2016, killing more than 11,000 people. That outbreak prompted a global push to develop vaccines and treatments — and some, including a protective shot developed by Merck and several antibody therapies for infected patients, have been deployed in the Congo outbreak.

vaccine
The technique, based on people exposed to the Ebola vaccine but not the Ebola virus itself, suggests protective therapies could be developed from people who are disease-free. Pixbay

Antibodies intended for treatment are normally collected from the blood of people who have survived infection. But they can also be tricky to obtain and carry heightened risks such as potential persistent viruses or other pathogens.

The Oxford team decided to try using blood from trial volunteers who had been given an experimental Ebola vaccine and whose immune system had responded to the shot by making antibodies. They successfully isolated 82 antibodies taken from 11 volunteers in trial at Oxford’s Jenner Institute.

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They found that despite having less time to develop, a third of the antibodies were effective at neutralizing a strain of Ebola known as Zaire — the one causing the Congo outbreak.

The scientists then made a cocktail of four of the antibodies to create a treatment, which successfully cured six guinea pigs of Ebola when it was administered three days after infection. (VOA)

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Congo: Ebola Deaths in East of Sprawling African Nation Nearing 2,000 and Cases of Virus Exceeds 3,000

The committee released the latest numbers Friday after a discussion in Goma by the Catholic Church and the Anglican Church about efforts

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Congo, Ebola, Deaths
FILE - A health worker wearing a protective suit enters an isolation pod to treat an Ebola patient at a treatment center in Beni, Democratic Republic of the Congo, July 13, 2019. VOA

Congo’s National Ebola Response Committee says confirmed Ebola deaths in the east of the sprawling African nation are nearing 2,000 and confirmed cases of the virus have exceeded 3,000. Congo.

The committee released the latest numbers Friday after a discussion in Goma by the Catholic Church and the Anglican Church about efforts to help stem the spread of Ebola in communities. A mistrust of health workers and widespread security issues still threaten the fight against the second deadliest outbreak of Ebola in history in a region where armed groups have fought for decades over the mineral-rich land.

Congo, Ebola, Deaths
Congo’s National Ebola Response Committee says confirmed Ebola deaths in the east of the sprawling African nation are nearing 2,000 and confirmed cases of the virus. Pixabay

The committee reported 3,002 confirmed Ebola cases with 1,974 deaths.

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The World Health Organization said Friday they recorded the lowest weekly incidence of Ebola since March 2019 with 40 new cases, but said it was unclear if this positive trend would continue. (VOA)