Friday, August 14, 2020
Home Lead Story New Antibody Approach to Tackle Ebola, Research To Make Successful Treatments For...

New Antibody Approach to Tackle Ebola, Research To Make Successful Treatments For The Deadly Viral Infection

Antibodies intended for treatment are normally collected from the blood of people who have survived infection. But they can also be tricky to obtain and carry heightened risks such as potential persistent viruses or other pathogens.

Scientists working on developing vaccines against Ebola have found they can “harvest” antibodies from volunteers vaccinated in research trials and use them to make treatments for the deadly viral infection.

In a study published Tuesday in the journal Cell Reports, the scientists said the approach could be used for Ebola and other newly emerging deadly diseases caused by viruses.

The technique, based on people exposed to the Ebola vaccine but not the Ebola virus itself, suggests protective therapies could be developed from people who are disease-free.

“It is a small, extra step that could lead to new antibody therapies from an increased pool of donors and with reduced risk,” said Alain Townsend, a professor at the MRC Human Immunology Unit at Britain’s Oxford University.

FILE - Health workers treat an unconfirmed Ebola patient inside an Ebola Treatment Center (ETC) in Butembo, Democratic Republic of the Congo, Nov. 3, 2018.
Health workers treat an unconfirmed Ebola patient inside an Ebola Treatment Center (ETC) in Butembo, Democratic Republic of the Congo, Nov. 3, 2018.

He noted that besides Ebola, many experimental vaccines for other life-threatening infections, such as H5N1 and H7N9 bird flu and Middle East Respiratory Syndrome (MERS), are entering clinical trials and could offer similar opportunities for antibodies to be collected.

Ebola is now spreading in Democratic Republic of Congo, where World Health Organization data show at least 676 people have been killed and more than 700 others infected in an outbreak that started eight months ago.

The largest Ebola epidemic in history swept through Sierra Leone, Liberia and Guinea in 2013-2016, killing more than 11,000 people. That outbreak prompted a global push to develop vaccines and treatments — and some, including a protective shot developed by Merck and several antibody therapies for infected patients, have been deployed in the Congo outbreak.

vaccine
The technique, based on people exposed to the Ebola vaccine but not the Ebola virus itself, suggests protective therapies could be developed from people who are disease-free. Pixbay

Antibodies intended for treatment are normally collected from the blood of people who have survived infection. But they can also be tricky to obtain and carry heightened risks such as potential persistent viruses or other pathogens.

The Oxford team decided to try using blood from trial volunteers who had been given an experimental Ebola vaccine and whose immune system had responded to the shot by making antibodies. They successfully isolated 82 antibodies taken from 11 volunteers in trial at Oxford’s Jenner Institute.

Also Read: NASA Wants Humans To Reach Mars By 2033

They found that despite having less time to develop, a third of the antibodies were effective at neutralizing a strain of Ebola known as Zaire — the one causing the Congo outbreak.

The scientists then made a cocktail of four of the antibodies to create a treatment, which successfully cured six guinea pigs of Ebola when it was administered three days after infection. (VOA)

STAY CONNECTED

18,956FansLike
362FollowersFollow
1,779FollowersFollow

Most Popular

Ayushmann is One of the Most Earnest Actors of our Generation, Says Vaani Kapoor

Actress Vaani Kapoor looks forward to working with Ayushmann Khurrana in an upcoming film. She says Ayushmann is one of the most earnest actors...

TV Stars are Looked Down Upon, I Don’t Know Why: Hina Khan

She did television for over a decade and has featured in Hindi films, but actress Hina Khan fails to understand why small screen stars...

Vidya Balan Does Not Like to Follow Norms

By Sugandha Rawal Vidya Balan does not like to follow norms. She finds it easier to follow her heart. The actress says doing something that...

Here are Some Home Gardening Tips For You

By Puja Gupta Growing and maintaining a garden at home is a fun and rewarding way to care for nature. Especially in these boredom-filled days...

Enjoy Independence Day Weekend With Domestic Travel

The fact that we are now free to move outside our homes after months in lockdown and travel, is the sweetest feeling of independence...

Everything You Need to Know About Post-Weaning Depression

By Puja Gupta Post-weaning depression is a form of mental illness which can occur after a woman stops breastfeeding. Like other depression, it requires immediate...

Car Not Turning On? Three Main Areas to Look Into

You are heading to somewhere important. You get in the car, turn the ignition, but the engine doesn’t crank. Your heart sinks because not...

Benefits Of Buying An Online Term Plan 

Choosing the best savings-investment plan can secure your future financially. A life insurance plan is one of the best ways that you can provide...

Recent Comments