Novel Artificial Pancreas System To Control Blood Sugar Levels in a Better Way

The device was shown to work for children as young as six - a crucial finding for a condition which often strikes in childhood

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Diabetes
According to the researchers, these novel findings may provide the basis for new therapies for patients who have heart disease complicated by diabetes. Pixabay

A novel artificial pancreas system can control blood sugar levels better than insulin injections for both children and older adults with Type-1 diabetes, results of a clinical trial have shown.

The findings, published in The Lancet, showed that the closed-loop insulin delivery system, as it is called, is better than sensor-augmented pump therapy for blood sugar control and reduced risk of hypoglycaemia — low sugar condition — in poorly controlled Type-1 diabetes patients.

“The use of day-and-night hybrid closed-loop insulin delivery improves glycaemic control while reducing the risk of hypoglycaemia in adults, adolescents and children with Type-1 diabetes compared to conventional pump therapy or sensor-augmented pump therapy,” said researchers including Roman Hovorka from the UK’s University of Cambridge.

“Type 1 diabetes is a challenging condition, but these results take us a step closer to changing the lives of millions of people that live with the condition across the world,” the researchers added.

The artificial pancreas resembles an iPod and is strapped to patients’ clothing with a small monitor and pump fitted to their skin and can both monitor blood sugar as well as inject insulin automatically if blood sugar gets too high, the Daily Mail reported.

Diabetes
Representational image. Pixabay

The device also allows patients to add doses of insulin manually, for example when they are about to eat a big meal.

Insulin pumps, on the other hand, monitors people’s blood sugar levels and warn them when it gets too low or high so they know whether to inject insulin or eat more.

For the trial, the team randomly assigned 44 male and 42 female patients with Type-1 diabetes aged six years and older to receive either hybrid closed-loop therapy or sensor-augmented pump therapy over 12 weeks.

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The amount of time people spent with ‘dangerously’ high or low blood sugar fell by 25 per cent for people using the artificial pancreas, but rose by 18 per cent for people using an ordinary insulin pump, the report said.

The device was shown to work for children as young as six – a crucial finding for a condition which often strikes in childhood. (IANS)

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Heavy Breakfast and Light Dinner Can Prevent Obesity

Want to lose weight? Have big breakfast, light dinner

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Eating a big breakfast rather than a large dinner may prevent obesity and high blood sugar. Pixabay

Eating a big breakfast rather than a large dinner may prevent obesity and high blood sugar, a new study suggests. This is a new health advice.

The findings, published in the The Journal of Clinical Endocrinology & Metabolism, researchers at the University of Lubeck in Germany, found that the body appears to be better at processing food in the morning.

According to the researchers, our body expends energy when we digest food for the absorption, digestion, transport and storage of nutrients.

This process, known as diet-induced thermogenesis (DIT), is a measure of how well our metabolism is working, and can differ depending on mealtime.

“Our results show that a meal eaten for breakfast, regardless of the amount of calories it contains, creates twice as high diet-induced thermogenesis as the same meal consumed for dinner,” said the study corresponding author, Juliane Richter, from University of Lübeck in Germany.

breakfast dinner
A meal eaten for breakfast, regardless of the amount of calories it contains, creates twice as high diet-induced thermogenesis as the same meal consumed for dinner. Pixabay

“This finding is significant for all people as it underlines the value of eating enough at breakfast,” Richter added.

For the results, the researchers conducted a three-day laboratory study of 16 men who consumed a low-calorie breakfast and high-calorie dinner, and vice versa in a second round.

They found identical calorie consumption led to 2.5 times higher DIT in the morning than in the evening after high-calorie and low-calorie meals.

The food-induced increase of blood sugar and insulin concentrations was diminished after breakfast compared with dinner, the study said.

The results also show eating a low-calorie breakfast increased appetite, specifically for sweets.

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“We recommend that patients with obesity as well as healthy people eat a large breakfast rather than a large dinner to reduce body weight and prevent metabolic diseases,” Richter said.

The study conducted at University of Lubeck in Northern Germany, is a research Institute, focuses almost entirely on medicine and sciences. (IANS)

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Here’s How Lipid in Human Body Can Help to Control Diabetes

The study's first author is Luiz Osorio Leiria, a researcher at the University of Campinas's Biology Institute (IB-UNICAMP) in Sao Paulo State, Brazil

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Diabetes
US researchers are currently conducting tests to measure the effects of relatively low doses of the drug on Diabetes. Pixabay

A team of global researchers has discovered that a lipid — produced in response to cold by brown adipose tissue in the human body — helps reduce Diabetes.

The discovery with the lipid known as 12-HEPE can pave the way for new treatments for diabetes, said the team from Brazil, the US and Germany.

The group also observed that a drug used to treat urinary dysfunction increases the amount of 12-HEPE released into the bloodstream in human patients.

White adipose tissue, one of the two types of adipose tissue in mammals, including humans, stores excess energy as fat.

The other kind is brown adipose tissue, which converts energy from food into heat and contributes to thermal regulation.

The function of the lipid “12-HEPE” was unknown until the group discovered that blood sugar was reduced more efficiently in obese mice treated with 12-HEPE than in untreated mice after they were injected with a concentrated glucose solution.

Diabetes
A team of global researchers has discovered that a lipid — produced in response to cold by brown adipose tissue in the human body — helps reduce Diabetes. Pixabay

According to the paper published in the journal Cell Metabolism, the beneficial effect of 12-HEPE on glucose tolerance in obese mice was due to its promotion of glucose uptake into both skeletal muscle and brown adipose tissue.

The study’s first author is Luiz Osorio Leiria, a researcher at the University of Campinas’s Biology Institute (IB-UNICAMP) in Sao Paulo State, Brazil.

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The discovery lays a foundation for the development of new drugs to combat diabetes and possible new treatments with currently available drugs.

US researchers are currently conducting tests to measure the effects of relatively low doses of the drug on Diabetes. (IANS)

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Study Says, Early Signs of Diabetes Can be Observed in Children

The study tracked over 4,000 participants of the Children of the 90s study, a birth cohort established in Bristol in the early 1990s

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Diabetes
The research was conducted among young healthy people who were generally free of type 2 Diabetes and other chronic diseases to see how early in life the effects of diabetes susceptibility become visible. Pixabay

Researchers have found that early signs of adulthood type 2 Diabetes can be seen in children as young as 8 years old.

Type 2 diabetes is most often diagnosed in middle age or later, with its symptoms slowly developing over many years.

“It’s remarkable that we can see signs of adult diabetes in the blood from such a young age, this is about 50 years before it’s commonly diagnosed.

“This is not a clinical study; nearly all participants were free of diabetes and most will not go on to develop it. This is about liability to disease and how genetics can tell us something about how the disease develops,” said study researcher Joshua Bell from the University of Bristol in the UK.

The research was conducted among young healthy people who were generally free of type 2 diabetes and other chronic diseases to see how early in life the effects of diabetes susceptibility become visible.

The study tracked over 4,000 participants of the Children of the 90s study, a birth cohort established in Bristol in the early 1990s.

The researchers combined genetics with an approach called ‘metabolomics’, which involves measuring many small molecules in a blood sample to try and identify patterns that are unique to type 2 diabetes.

According to the findings, the research team analysed 162 pieces of genetic information and combined this with 200 measures of many small molecules in a blood sample, known as metabolics, to identify signs of type 2 diabetes.

Diabetes
Researchers have found that early signs of adulthood type 2 Diabetes can be seen in children as young as 8 years old. Pixabay

Data was taken once in childhood — at 8 years old, twice in adolescence aged 16 and 18 years and once in young adulthood aged 25 years.

They found levels of HDL cholesterol were reduced at age 8, while inflammatory glycoprotein acetyls and amino acids were elevated in 16 and 18 year old teenagers.

These metabolic features could be targeted to prevent young people from going on to develop type 2 diabetes in the future, the researchers said.

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The findings were presented at the European Association for the Study of Diabetes (EASD) Annual Meeting in Barcelona. (IANS)