Saturday January 25, 2020

Novel Artificial Pancreas System To Control Blood Sugar Levels in a Better Way

The device was shown to work for children as young as six - a crucial finding for a condition which often strikes in childhood

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Diabetes
According to the researchers, these novel findings may provide the basis for new therapies for patients who have heart disease complicated by diabetes. Pixabay

A novel artificial pancreas system can control blood sugar levels better than insulin injections for both children and older adults with Type-1 diabetes, results of a clinical trial have shown.

The findings, published in The Lancet, showed that the closed-loop insulin delivery system, as it is called, is better than sensor-augmented pump therapy for blood sugar control and reduced risk of hypoglycaemia — low sugar condition — in poorly controlled Type-1 diabetes patients.

“The use of day-and-night hybrid closed-loop insulin delivery improves glycaemic control while reducing the risk of hypoglycaemia in adults, adolescents and children with Type-1 diabetes compared to conventional pump therapy or sensor-augmented pump therapy,” said researchers including Roman Hovorka from the UK’s University of Cambridge.

“Type 1 diabetes is a challenging condition, but these results take us a step closer to changing the lives of millions of people that live with the condition across the world,” the researchers added.

The artificial pancreas resembles an iPod and is strapped to patients’ clothing with a small monitor and pump fitted to their skin and can both monitor blood sugar as well as inject insulin automatically if blood sugar gets too high, the Daily Mail reported.

Diabetes
Representational image. Pixabay

The device also allows patients to add doses of insulin manually, for example when they are about to eat a big meal.

Insulin pumps, on the other hand, monitors people’s blood sugar levels and warn them when it gets too low or high so they know whether to inject insulin or eat more.

For the trial, the team randomly assigned 44 male and 42 female patients with Type-1 diabetes aged six years and older to receive either hybrid closed-loop therapy or sensor-augmented pump therapy over 12 weeks.

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The amount of time people spent with ‘dangerously’ high or low blood sugar fell by 25 per cent for people using the artificial pancreas, but rose by 18 per cent for people using an ordinary insulin pump, the report said.

The device was shown to work for children as young as six – a crucial finding for a condition which often strikes in childhood. (IANS)

Next Story

Here’s How Lipid in Human Body Can Help to Control Diabetes

The study's first author is Luiz Osorio Leiria, a researcher at the University of Campinas's Biology Institute (IB-UNICAMP) in Sao Paulo State, Brazil

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Diabetes
US researchers are currently conducting tests to measure the effects of relatively low doses of the drug on Diabetes. Pixabay

A team of global researchers has discovered that a lipid — produced in response to cold by brown adipose tissue in the human body — helps reduce Diabetes.

The discovery with the lipid known as 12-HEPE can pave the way for new treatments for diabetes, said the team from Brazil, the US and Germany.

The group also observed that a drug used to treat urinary dysfunction increases the amount of 12-HEPE released into the bloodstream in human patients.

White adipose tissue, one of the two types of adipose tissue in mammals, including humans, stores excess energy as fat.

The other kind is brown adipose tissue, which converts energy from food into heat and contributes to thermal regulation.

The function of the lipid “12-HEPE” was unknown until the group discovered that blood sugar was reduced more efficiently in obese mice treated with 12-HEPE than in untreated mice after they were injected with a concentrated glucose solution.

Diabetes
A team of global researchers has discovered that a lipid — produced in response to cold by brown adipose tissue in the human body — helps reduce Diabetes. Pixabay

According to the paper published in the journal Cell Metabolism, the beneficial effect of 12-HEPE on glucose tolerance in obese mice was due to its promotion of glucose uptake into both skeletal muscle and brown adipose tissue.

The study’s first author is Luiz Osorio Leiria, a researcher at the University of Campinas’s Biology Institute (IB-UNICAMP) in Sao Paulo State, Brazil.

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The discovery lays a foundation for the development of new drugs to combat diabetes and possible new treatments with currently available drugs.

US researchers are currently conducting tests to measure the effects of relatively low doses of the drug on Diabetes. (IANS)