Saturday December 14, 2019

Aspirin Can Help to Fight Against Tuberculosis, Says Study

India has the world's highest burden of TB, with 27 per cent of all global cases and over 30 per cent of all deaths worldwide

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Aspirin, Ovarian cancer
New ingestible, expanding pill to track ulcers, stomach cancer.

Aspirin can prevent the tuberculosis (TB) bacterium from hijacking immune cells and allow the body to control infection better, say researchers who found that the common pain killer could treat the top infectious killer worldwide that claims around 4,400 lives a day.

Researchers from the Centenary Institute in Sydney found that the TB bacterium hijacks platelets from the body’s blood clotting system to weaken immune systems.

“Our study provides more crucial evidence that widely available aspirin could be used to treat patients with severe TB infection and save lives,” said lead author Elinor Hortle, research officer at Centenary.

Using the zebrafish model of TB, the team used fluorescent microscopy to observe the build-up of clots and activation of platelets around sites of infection.

They found that the platelets were being tricked by the infection into getting in the way of the body’s immune system.

Treating the infections with anti-platelet drugs, including the widely available aspirin, the researchers said, could prevent hijacking and allow the body to control infection better, according to the paper published in The Journal of Infectious Diseases.

Aspirin
Aspirin may lower risk of ovarian cancer as well. Pixabay

“This is the first time that platelets have been found to worsen TB in an animal model. It opens up the possibility that anti-platelet drugs could be used to help the immune system fight off drug resistant TB,” Hortle said.

According to the World Health Organization, TB is one of the top 10 causes of death worldwide.

In 2017, 10 million people fell ill with TB, and 1.6 million died from the disease (including 0.3 million among people with HIV).

Also Read- Possibilities of UN Banning Killer Robots Looking Growingly Remote

The infection also accounted for death in 230,000 children (including children with HIV associated TB) in 2017.

India has the world’s highest burden of TB, with 27 per cent of all global cases and over 30 per cent of all deaths worldwide. (IANS)

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Aspirin may Treat Acute Migraines Efficiently: Study

Aspirin can be safe option to treat migraines

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Aspirin treats migraines
Aspirin can be considered an effective and safe option to treat acute migraines. Lifetime Stock

Aspirin can be considered an effective and safe option to other, more expensive medications to treat acute migraines as well as prevent recurrent attacks, a new study suggests.

The review, published in the American Journal of Medicine, includes evidence from 13 randomised trials of the treatment of migraine in 4,222 patients and tens of thousands of patients in prevention of recurrent attacks.

The findings suggest that high-dose aspirin, in doses from 900 to 1,300 milligrams given at the onset of symptoms, is an effective and safe treatment option for acute migraine headaches.

In addition, some but not all randomised trials suggest the possibility that daily aspirin in doses from 81 to 325 milligrams may be an effective and safe treatment option for the prevention of recurrent migraine headaches.

“Our review supports the use of high dose aspirin to treat acute migraine as well as low dose daily aspirin to prevent recurrent attacks,” said study researcher Charles H. Hennekens from Florida Atlantic University in the US.

“Moreover, the relatively favourable side effect profile of aspirin and extremely low costs compared with other prescription drug therapies may provide additional clinical options for primary health care providers treating acute as well as recurrent migraine headaches,” Hennekens added.

Aspirin
Aspirin is less expensive as compared to other medications that treat migraines. Lifetime Stock

Common symptoms of migraine include a headache that often begins as a dull pain and then grows into a throbbing pain, which can be incapacitating and often occurs with nausea and vomiting, and sensitivity to sound, light and smell.

Migraines can last anywhere from four to 72 hours and may occur as many times as several times a week to only once a year.

“Migraine headaches are among the most common and potentially debilitating disorders encountered by primary health care providers,” said study first author Bianca Biglione.

“In fact, about one in 10 primary care patients present with headache and three out of four are migraines. Aspirin is readily available without a prescription, is inexpensive, and based on our review, was shown to be effective in many migraine patients when compared with alternative more expensive therapies,” Biglion added.

Approximately 36 million Americans suffer from migraine headaches and the cause of this disabling disorder is not well understood. There is a higher prevalence in women (18 per cent) than men (nine per cent).

Also Read- Protein Deficiency Ordinary Among Indians: Experts

In women, the prevalence is highest during childbearing age.

According to the researchers, approximately 90 per cent of migraine sufferers report moderate to severe pain, with more than 50 per cent reporting severe impairment or the need for bed rest as well as reduced work or school productivity. (IANS)