Tuesday July 17, 2018

Using aspirin may reduce obesity’s effect on cancer, finds study

To study how obesity affects this defence mechanism, the team bred mice that were designed to express a known cancer-inducing mutant protein called Ras.

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To study how obesity affects this defense mechanism, the team bred mice that were designed to express a known cancer-inducing mutant protein called Ras.
Representational Image, Pixabay
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Aspirin, a medication used to treat pain, fever or inflammation, could significantly reduce the effects of obesity on cancer, suggests a study on mice.

Obesity is a known risk factor for certain types of cancer, including colon, pancreatic and breast cancer.

The new study, from Hokkaido University in Sapporo, Japan, showed that obesity could enhance cancer development by slowing down the key cancer defence mechanism.

“Epithelial” cells lining the surfaces of organs have the intrinsic ability to remove potentially malignant cells from their midst. This is called the “epithelial defense against cancer” mechanism.

Normally, the cells sense harmful cells and push them out by the process called cell competition.

Obesity is a known risk factor for certain types of cancer, including colon, pancreatic and breast cancer.
Medicines. Pixabay

“This is the first report to show that obesity and chronic inflammation can influence competitive interaction between normal cells and transformed cells,” said lead author Yasuyuki Fujita.

“It implies other factors such as infection, smoking, sleeping patterns and ageing may also affect cell competition,” Fujita added.

To study how obesity affects this defense mechanism, the team bred mice that were designed to express a known cancer-inducing mutant protein called Ras.

Epithelial cells usually remove the potentially malignant Ras-transformed cells.

Feeding the Ras mice high-fat diets, which resulted in severe obesity, suppressed the defense mechanism and therefore increased the number of Ras-transformed cells remaining in the tissue.

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This suppression was seen in the intestine and pancreas, but not in the lungs, the researchers noted.

A month later, the Ras-transformed cells developed a tumor in the pancreas of mice with the high-fat diet.

Further experiments using the mice model and cultured cells revealed that fatty acids and chronic inflammation cause the suppression of the defense mechanism.

However, when mice fed a high-fat diet were treated with aspirin, known for its anti-inflammatory properties, the defense mechanism was substantially enhanced.

This implies that reinforcing the epithelial defense mechanism with anti-inflammatory drugs could be utilized for cancer prevention, the researchers said. (IANS)

 

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Meditation Improves Mood, Sleep in Teenagers with Cancer

The mindfulness-based interventions for teenagers with cancer appear as a promising option to lighten psychological inconveniences of living with cancer

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The process focuses on the present moment and the connection between the mind and body. Pixabay

Daily meditation can help improve mood and sleep in teenagers suffering or recuperating from cancer, a promising research shows.

Mindfulness-based meditation could lessen some symptoms associated with cancer in teenagers, according to the results of a clinical trial intervention led by researchers at University of Montreal and its affiliated CHU Sainte-Justine children’s hospital.

The process focuses on the present moment and the connection between the mind and body.

Adolescents living with cancer face not only the physical symptoms of their condition but also the anxiety and uncertainty related to the progression of the disease and the anticipation of physical and emotional pain related to illness and treatment.

meditation
Daily meditation can help improve mood and sleep in teenagers suffering or recuperating from cancer. Pixabay

The researchers asked 13 adolescents with cancer to complete questionnaires covering mood (positive and negative emotions, anxiety and depression), sleep and quality of life.
The group was divided in two. The first group of eight adolescents were offered eight mindfulness-based meditation sessions and the remaining five adolescents in the control group were put on a wait-list.

After the last meditation session, patients from both groups filled out the same questionnaires a second time.

Also Read: Daily Meditation may keep you attentive in old age

“We found that teenagers that participated in the mindfulness group had lower scores in depression after our eight sessions. Girls from the mindfulness group reported sleeping better. We also noticed that they developed mindfulness skills to a greater extent than boys during the sessions,” explained Catherine Malboeuf-Hurtubise from University of Montreal.

The mindfulness-based interventions for teenagers with cancer appear as a promising option to lighten psychological inconveniences of living with cancer, she added. (IANS)

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