Wednesday January 16, 2019

Using aspirin may reduce obesity’s effect on cancer, finds study

To study how obesity affects this defence mechanism, the team bred mice that were designed to express a known cancer-inducing mutant protein called Ras.

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To study how obesity affects this defense mechanism, the team bred mice that were designed to express a known cancer-inducing mutant protein called Ras.
Representational Image, Pixabay

Aspirin, a medication used to treat pain, fever or inflammation, could significantly reduce the effects of obesity on cancer, suggests a study on mice.

Obesity is a known risk factor for certain types of cancer, including colon, pancreatic and breast cancer.

The new study, from Hokkaido University in Sapporo, Japan, showed that obesity could enhance cancer development by slowing down the key cancer defence mechanism.

“Epithelial” cells lining the surfaces of organs have the intrinsic ability to remove potentially malignant cells from their midst. This is called the “epithelial defense against cancer” mechanism.

Normally, the cells sense harmful cells and push them out by the process called cell competition.

Obesity is a known risk factor for certain types of cancer, including colon, pancreatic and breast cancer.
Medicines. Pixabay

“This is the first report to show that obesity and chronic inflammation can influence competitive interaction between normal cells and transformed cells,” said lead author Yasuyuki Fujita.

“It implies other factors such as infection, smoking, sleeping patterns and ageing may also affect cell competition,” Fujita added.

To study how obesity affects this defense mechanism, the team bred mice that were designed to express a known cancer-inducing mutant protein called Ras.

Epithelial cells usually remove the potentially malignant Ras-transformed cells.

Feeding the Ras mice high-fat diets, which resulted in severe obesity, suppressed the defense mechanism and therefore increased the number of Ras-transformed cells remaining in the tissue.

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This suppression was seen in the intestine and pancreas, but not in the lungs, the researchers noted.

A month later, the Ras-transformed cells developed a tumor in the pancreas of mice with the high-fat diet.

Further experiments using the mice model and cultured cells revealed that fatty acids and chronic inflammation cause the suppression of the defense mechanism.

However, when mice fed a high-fat diet were treated with aspirin, known for its anti-inflammatory properties, the defense mechanism was substantially enhanced.

This implies that reinforcing the epithelial defense mechanism with anti-inflammatory drugs could be utilized for cancer prevention, the researchers said. (IANS)

 

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Risk Of Suicide Quadruples With Cancer: Study

The results could be used to help identify patients who may be at a higher risk for suicide and help health care providers tailor their treatments accordingly.

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A Family In Delhi Commits Suicide To Thank God: Police Reports
While the risk of suicide decreases five years after a diagnosis, the risk remains high for patients with Hodgkin lymphoma and testicular cancer.

People with cancer are over four times more likely to commit suicide than people without the deadly disease, finds a study.

According to researchers from the Penn State Cancer Institute in Pennsylvania, while a lot of progress has been made in treating cancer, not as much research has been put into how cancer affects patients mentally and emotionally.

“Even though cancer is one of the leading causes of death, most cancer patients do not die from cancer, the patients usually die of another cause,” said Nicholas Zaorsky, radiation oncologist at the Penn State Cancer Institute.

“There are multiple competing risks for death, and one of them is suicide. Distress and depression can arise from cancer diagnosis, treatment, financial stress, and other causes. Ultimately, distress and depression may lead to suicide. Our goal was to quantify the risk of suicide among cancer patients,” he added.

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The study, published in the Nature Communications journal, the team compared the risk of suicide in eight million patients who had been diagnosed with cancer and those without.

They found that among people with cancer, males, patients who were diagnosed at a younger age, patients with lung, head, neck and testicular cancer, and lymphomas were more likely to commit suicide.

While the risk of suicide decreases five years after a diagnosis, the risk remains high for patients with Hodgkin lymphoma and testicular cancer.

“Treatments for some cancers — like leukemia and testicular cancer among adolescents and young adults, for example — can decrease a patient’s fertility, and that seems to be one of the risks for suicide in the long term,” Zaorsky said.

Also Read: Here’s What Causes Cancer in Children

“In contrast, elderly patients who are diagnosed with lung, prostate and head and neck cancers, are at an increased risk of suicide for the remainder of their life.”

The results could be used to help identify patients who may be at a higher risk for suicide and help health care providers tailor their treatments accordingly. (IANS)