Tuesday January 21, 2020

Researchers Identify Extract From Avocado Seeds Exhibiting Anti-inflammatory Properties

Avocado seed extract shows anti-inflammatory activity

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more than 80% of avocados are grown in California, where there is a drought
more than 80% of avocados are grown in California, where there is a drought. Pixabay

Researchers have identified that an extract from avocado seeds exhibited anti-inflammatory properties in a laboratory study.

The team, including Joshua Lambert from Penn State, said that it represents a potential source for novel anti-inflammatory compounds that could be developed as a functional food ingredient or pharmaceuticals.

The researchers developed the extract over the last decade as a food colourant and it is not known whether the compounds responsible for the extract’s vibrant orange colour play any role in its ability to inhibit the production of pro-inflammatory mediators, said Lambert.

To determine the anti-inflammatory properties of the avocado seed extract, the researchers used cell culture models and enzymes that are important in immune response and inflammatory diseases.

A class of immune cells called macrophages were grown in petri dishes and activated with a pro-inflammatory stimuli in the presence or absence of the avocado seed extract.

Avocado boxes are collected an avocado orchard in Michoacan, Mexico, Jan. 16, 2014.

The researchers measured the production of important pro-inflammatory mediators and signalling pathways in the cells after treatment with the extract.

“The next step, before we can draw further conclusions about the anti-inflammatory activity of this avocado seed extract, will be to design animal model studies,” Lambert explained.

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“The level of activity that we see from the extract is very good. We saw inhibitory activity at concentrations in the low microgram-per-millilitre range, which is an acceptable amount of activity to justify further studies,” Lambert added.

The discovery could be important because cancer, cardiovascular diseases, arthritis, colitis and many more serious conditions are associated with chronic inflammation, suggests the study published in the journal Advances in Food Technology and Nutritional Sciences. (IANS)

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Usage of Anti-Inflammatory Drugs to Curb Symptoms of Depression, still Controversial

We cannot say anti-inflammatory drugs will tackle the issue

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Anti-Inflammatory, Drugs, Depression
A lot of studies are taking place around the world regarding this but none of them had shown 100 per cent cure, Kumar told IANS. Pixabay

Although researchers abroad claim that anti-inflammatory agents such as aspirin or paracetamol can safely and effectively curb the symptoms of major depression, doctors here dispute the claim.

According to Rajnish Kumar, Neurologist, Paras Hospital in Gurugram, usage of anti-inflammatory drugs to curb symptoms of depression is still controversial.

“We haven’t seen any such cases where anti-inflammatory drugs like aspirin, paracetamol or brufen have helped a patient. A lot of studies are taking place around the world regarding this but none of them had shown 100 per cent cure,” Kumar told IANS.

“We cannot say anti-inflammatory drugs will tackle the issue. These drugs will have more counter-productive action as compared to curbing the depression symptoms. So, these agents won’t be that beneficial,” Kumar stressed.

Anti-Inflammatory, Drugs, Depression
According to Rajnish Kumar, Neurologist, Paras Hospital in Gurugram, usage of anti-inflammatory drugs to curb symptoms of depression is still controversial. Pixabay

For undertaking the study on the curative aspects of anti-inflammatory agents, researchers trawled databases to find suitable studies published up to January 2019. They have found 30 relevant randomised controlled trials, involving 1,610 people, which reported changes in depression scales.

They pooled the data from 26 of these studies.

The study, published in the US in the Journal of Neurology Neurosurgery and Psychiatry, suggested that anti-inflammatory agents were better than placebo and enhanced the effects of standard antidepressant treatment.

The effects were even greater when one or other of these agents were added to standard antidepressant treatment.

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“The study claims that OTC drugs like aspirin and brufen can be used in depressive disorders. However it’s premature to accept this in routine clinical practice as yet,” said Tarun Sahni, Senior Consultant, Internal Medicine, Indraprastha Apollo Hospitals in Delhi.

“The danger is that this may lead to self-diagnosing and medication for such illnesses and therefore the risk of delay in it with increased morbidity,” Gupta added.

However, Rahul Gupta, Director of Department of Neurosurgery, Fortis Hospital in Nodia, said that anti-inflammatory medicine like aspirin in low doses can be effective in Psychiatric illnesses like bipolar disorder.

“In bipolar disorder, there is evidence of chronic inflammation and elevated pro-inflammatory cytokines. Aspirin, by its capacity to inhibit COX 1 enzyme, can reduce the inflammatory process in the brain. It down-regulates the brain arachidonic acid (AA) cascade to reduce neuroinflammation and excitotoxicity of neurons,” Gupta explained.

Anti-Inflammatory, Drugs, Depression
We haven’t seen any such cases where anti-inflammatory drugs like aspirin, paracetamol or brufen have helped a patient. Pixabay

“This has been hypothesised to reduce the symptoms in bipolar disorder. Also, it augments the effect of conventional anti-depressants in major depressive disorder and is helpful in resistant cases,” Gupta told IANS.

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“The doses of conventional medicines can be reduced and side effects like nausea, insomnia, weight gain, and suicidal thoughts can be reduced,” he concluded. (IANS)