Tuesday January 21, 2020
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Health Alert! Be Cautious While Taking Pills With Inactive Ingredients, Can Lead To Adverse Reactions

"While we call these ingredients 'inactive', in many cases they are not. While the doses may be low, we don't know what the threshold is for individuals to react in the majority of instances," the researchers noted. 

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medicines
For certain drugs, such as progesterone, there are few alternatives that do not contain this inactive ingredient. VOA

Be cautious while taking medicines as a new study suggests that some ingredients added to pills to improve their shelf life may cause allergy or lead to adverse reactions.

The study found that more than 90 per cent of all oral medications tested contained at least one ingredient including lactose, peanut oil, gluten and chemical dyes that can cause gastrointestinal issues and difficulty in breathing in sensitive individuals.

These components are added to improve the taste, shelf life, absorption and other characteristics of a pill, said researchers from the Massachusetts Institute of Technology (MIT) in the US.

Pills
“While we call these ingredients ‘inactive’, in many cases they are not. While the doses may be low, we don’t know what the threshold is for individuals to react in the majority of instances,” the researchers noted. 
VOA

“There are hundreds of different versions of pills or capsules that deliver the same medication using a different combination of inactive ingredients,” said Daniel Reker from the varsity.

For the study, published in the journal Science Translational Medicine, the team analysed data on inactive ingredients in over 42,000 oral medications that contained more than 350,000 inactive ingredients.

The findings showed a total of 38 inactive ingredients that cause allergic symptoms after oral exposure. Approximately 45 per cent of medications contained lactose, nearly 33 per cent contained a food dye, and 0.08 per cent contained peanut oil.

Pills
“There are hundreds of different versions of pills or capsules that deliver the same medication using a different combination of inactive ingredients,” VOA

For certain drugs, such as progesterone, there are few alternatives that do not contain this inactive ingredient.

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“While we call these ingredients ‘inactive’, in many cases they are not. While the doses may be low, we don’t know what the threshold is for individuals to react in the majority of instances,” the researchers noted.

Precision care and the role for regulation and legislation are essential when it comes to labelling medications that contain an ingredient that may cause an adverse reaction, the team suggested. (IANS)

Next Story

This New Method Can Improve The Development of New Medicines

By dialling the parameters in this new mathematical model, researchers can quickly understand how these different binding configurations are affected

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Medicines
A New computational model will make research much more efficient and could accelerate the creation of new Medicines and therapies for many kinds of diseases. Pixabay

A new mathematical framework on molecular interactions will make it easier and more efficient for scientists to develop new medicines and other therapies for diseases such as cancer, HIV and autoimmune diseases, say reseachers.

The mathematical framework simulates the effects of the key parameters that control interactions between molecules that have multiple binding sites, as is the case for many medicines, the researchers said in a study, published in the journal Proceedings of the National Academy of Sciences (PNAS). The researchers have planned to use this computational model to develop a web-based app that other researchers can use to speed the development of new therapies for diseases.

“The big advance with this study is that usually researchers use a trial-and-error experimental method in the lab for studying these kinds of molecular interactions, but here we developed a mathematical model where we know the parameters so we can make accurate predictions using a computer,” said Indian-origin researcher and study senior author Casim Sarkar from University of Minnesota in the US.

“This computational model will make research much more efficient and could accelerate the creation of new therapies for many kinds of diseases,” Sarkar added.

For the findings, the research team studied three main parameters of molecular interactions–binding strength of each site, rigidity of the linkages between the sites, and the size of the linkage arrays.

They looked at how these three parameters can be ‘dialled up’ or ‘dialled down’ to control how molecule chains with two or three binding sites interact with one another. The team then confirmed their model predictions in lab experiments. “At a fundamental level, many diseases can be traced to a molecule not binding correctly,” said study lead author Wesley Errington.

“By understanding how we can manipulate these ‘dials’ that control molecular behaviour, we have developed a new programming language that can be used to predict how molecules will bind,” Errington added.

Medicines
A new mathematical framework on molecular interactions will make it easier and more efficient for scientists to develop new medicines and other therapies for diseases such as cancer, HIV and autoimmune diseases, say reseachers. Pixabay

The need for a mathematical framework to decode this programming language is highlighted by the researchers’ finding that, even when the interacting molecule chains have just three binding sites each, there are a total of 78 unique binding configurations, most of which cannot be experimentally observed.

By dialling the parameters in this new mathematical model, researchers can quickly understand how these different binding configurations are affected, and tune them for a wide range of biological and medical applications. “We think we’ve hit on rules that are fundamental to all molecules, such as proteins, DNA, and medicines, and can be scaled up for more complex interactions,” said Errington.

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“It’s really a molecular signature that we can use to study and to engineer molecular systems. The sky is the limit with this approach,” Errington added. (IANS)