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Beetroot compound may prevent Alzheimer’s

The team investigated betanin's potential to block the effects of copper on beta-amyloid and, in turn, prevent the misfolding of these peptides and the oxidation of neurons

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Beetroot can help prevent Alzheimer's disease. IANS
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  • Beetroot can help prevent Alzheimer’s disease
  • A compound found in it can also lead to the development of drugs for the disease
  • Betanin found in it can do wonders for the patients of Alzheimer’s

A compound found in beetroot that gives the vegetable its distinctive red colour could help prevent Alzheimer’s, finds a study that could lead to the development of drugs for treating the disease.

The findings showed that the compound betanin in beetroot extract could eventually help slow the accumulation of misfolded proteins in the brain, a process that is associated with Alzheimer’s disease.

Diabetes drug could now treat Alzheimer's disease
Beetroot compounds can help develop a drug for Alzheimer’s disease. IANS

“Our data suggest that betanin shows some promise as an inhibitor of certain chemical reactions in the brain that are involved in the progression of Alzheimer’s disease,” said Li-June Ming, from the University of South Florida.

Beta-amyloid is a sticky protein fragment, or peptide, that accumulates in the brain, disrupting communication between brain cells called neurons. Much of the damage occurs, when beta-amyloid attaches itself to metals such as iron or copper.

Also Read: Could diabetes drug cure Alzheimer’s disease?

These metals can cause beta-amyloid peptides to misfold and bind together in clumps that can promote inflammation and oxidation — a process similar to rusting — in nearby neurons, eventually killing them. Betanin is also used in commercial dyes that readily binds to metals. The team investigated betanin’s potential to block the effects of copper on beta-amyloid and, in turn, prevent the misfolding of these peptides and the oxidation of neurons.

When betanin was added to the copper-bound beta-amyloid mixture, the researchers found oxidation dropped by as much as 90 percent, suggesting that misfolding of the peptides was potentially suppressed. “We can’t say that betanin stops the misfolding completely, but we can say that it reduces oxidation,” noted Darrell Cole Cerrato from the varsity.

Pixabay
Betanin present in beetroot can help the patients. Pixabay

“Less oxidation could prevent misfolding to a certain degree, perhaps even to the point that it slows the aggregation of beta-amyloid peptides, which is believed to be the ultimate cause of Alzheimer’s,” Cerrato explained. The results were presented at the 255th National Meeting & Exposition of the American Chemical Society in New Orleans. IANS

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Managing Cholesterol Might Help To Reduce Alzheimer’s Risk

These included several points within the CELF1/MTCH2/SPI1 region on chromosome 11 that previously had been linked to the immune system

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Can managing cholesterol reduce Alzheimer's risk? Read it out here. Pixabay

Managing cholesterol might help reduce Alzheimer’s risk, says researchers, including one of Indian-origin, who identified a genetic link between the progressive brain disorder and heart disease.

Examining DNA from more than 1.5 million people, the study showed that risk factors for heart disease such as elevated triglyceride and cholesterol levels (HDL, LDL, and total cholesterol) were genetically related to Alzheimer’s risk.

However, genes that contribute to other cardiovascular risk factors, like body mass index and Type-2 diabetes, did not seem to contribute to genetic risk for Alzheimer’s.

“The genes that influenced lipid metabolism were the ones that also were related to Alzheimer’s disease risk,” said Celeste M. Karch, Assistant Professor at the Washington University’s School of Medicine.

Thus, if the right genes and proteins could be targeted, it may be possible to lower the risk for Alzheimer’s disease in some people by managing their cholesterol and triglycerides, added Rahul S. Desikan, Assistant Professor at the UCSF.

For the study, published in the journal Acta Neuropathologica, the team identified points of DNA that increase the risk of cardiovascular disease and also heighten the risk for Alzheimer’s disease.

"The question for us now is not how to eliminate cholesterol from the brain, but about how to control cholesterol's role in Alzheimer's disease through the regulation of its interaction with amyloid-beta," Vendruscolo said.
In Alzheimer’s disease, patients start losing memory, Pixabay

The team looked at differences in the DNA of people with factors that contribute to heart disease or Alzheimer’s disease and identified 90 points across the genome that were associated with risk for both diseases.

Their analysis confirmed that six of the 90 regions had very strong effects on Alzheimer’s and heightened blood lipid levels, including several within genes that had not previously been linked to dementia risk.

These included several points within the CELF1/MTCH2/SPI1 region on chromosome 11 that previously had been linked to the immune system.

Also Read- Longer Exposure to Honking Traffic Makes You Obese

The researchers confirmed their findings in a large genetic study of healthy adults by showing that these same risk factors were more common in people with a family history of Alzheimer’s, even though they had not themselves developed dementia or other symptoms such as memory loss.

“These results imply that cardiovascular and Alzheimer’s pathology co-occur because they are linked genetically. That is, if you carry this handful of gene variants, you may be at risk not only for heart disease but also for Alzheimer’s,” Desikan said. (IANS)