Wednesday, September 30, 2020
Home Life Style Health & Fitness Bioinformatics Method to be Used to Study Communication Between Cells

Bioinformatics Method to be Used to Study Communication Between Cells

Do you know how a cell interacts with the other? The way you do on Twitter. Now, computational biologists have developed a new bioinformatics method to better study communication between cells.

The method, called NicheNet, helps researchers gain insight into how the gene expression of cells is regulated by interacting cells.

Studying intercellular communication is not only important to understand fundamental biology, but also to gain insights into diseases like cancer.

Interactions between cancer cells and others in the microenvironment of the tumour are crucial for its growth.

Led by Professor Ivan Saeys from VIB-UGent Center for Inflammation Research in Belgium developed this new bioinformatics method.

NicheNet has a broad range of potential applications in fields like immunology and tumour biology, say researchers.

cells
Computational biologists have developed a new bioinformatics method to better study communication between cells. (Representational Image). Pixabay

Researchers used the method to study Kupffer cells, a macrophage in the liver blood stream. They generated a lot of gene expression data of all cells involved.

“But, using this type of data to unravel how a cell communicates is not a trivial task”, said Saeys. “We needed to develop a new sophisticated algorithm to tackle this problem”.

Researchers were able to experimentally validate some of the signals that NicheNet predicted.

“Thanks to NicheNet, we looked into factors that we would not have thought about ourselves”, confirms Martin Guilliams from VIB-Ghent University, who works in close collaboration with the Saeys lab.

“For us, NicheNet was an essential tool to help unravel the Kupffer cell niche”.

In addition to the Kupffer cell story, the team has also been applying NicheNet to investigate cell-cell communication in the tumour microenvironment.

Also Read- Investors in Vietnam to be More Cautious With Investing in Tech Startups

“We used NicheNet on single-cell data that was published earlier, but we are now working on novel single-cell datasets generated by collaborating research groups,” said Saeys in a paper published in the journals Nature Methods and Immunity.

An example of a process in which intercellular communication is essential, is the differentiation of macrophages, a type of immune cell. This process is affected by other cell types in the environment, or “niche”, of the macrophage. (IANS)

STAY CONNECTED

19,133FansLike
362FollowersFollow
1,779FollowersFollow

Most Popular

Jewelry: An Investment and a Sentiment

After a tough six months of pandemic (and continuing) wherein most of us were resigned to our homes and restrained ourselves from socializing, finally...

Is There Greater Risk of Heart Disease to Men than Women?

Over the years, multiple researchers have concluded that heart disease impacts men and women differently. It has been noted that in the younger age...

Knowing the Basics of Your Sneaker Shoes

Sneaker Shoes have taken over the world and how! Understandably so, because who would do not want to sport footwear that is not only...

Fusion Taking Over in Indian Kitchens

Owing to the pandemic, food consumption has become a cautious habit and people are highly conscious of what they are eating and where it...

Sean Toy Provides Rudimentary Overview of Nutrition

Nutrition makes up the second half of the exercise equation, with work and effort being the other, yet many who are committed to consistently...

Reviewing the Song ‘Bol re Dilli Bol’ by Kailash Kher

BY RADHIKA TANDON The song Bol re Dilli Bol, vocalized by Kailash Kher, is indeed a thought-provoking song that leaves you gutted to your core....

How To Become An Influencer On Angel Amplifiers

Marketing techniques and strategies are changing. With the advent of the digital age, brands and companies are also evolving, cruising towards online marketing. This...

Virtual ‘Deepotsav’ in Ayodhya Instead of Ram Lila

The Ayodhya administration has denied permission for Ram Lila in Ayodhya due to the coronavirus pandemic, however, the administration has started preparations to organize...

Recent Comments