Tuesday April 24, 2018

New Biomarker Helps Identify Cancer Chemotherapy Timing

Angiogenesis therapy is clinically used to suppress tumour growth. Adding an anti-angiogenic drug can boost an anticancer drug's effectiveness

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Biomarker can be used to decide timing fro chemotherapy.
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In ray of hope for doctors to identify the tumour normalising period for effective timing of anti-cancer drug treatment, a team of researchers have discovered a new biomarker that can visualise the activity of blood vessels.

Angiogenesis, the formation of new blood vessels, is essential for tumour growth. The team from Osaka University in Japan, in a paper reported in The American Journal of Pathology, described a vascular stabilization biomarker that can visualize blood vessel activity, thus optimising the timing of anticancer therapies including anti-angiogenics.

Chronic diseases are not yet included in cancer prevention schemes.
This can help cancer patients greatly.

Combination therapy using angiogenesis inhibitors and anticancer drugs can improve drug delivery into tumour tissues and prolong progression-free survival. “Vascular normalisation by angiogenesis inhibitors, such as vascular endothelial growth factor (VEGF) signaling inhibitors, is a promising method for improvement of chemotherapy.

“However, it is unclear how we can recognise the ‘window of opportunity’ for the tumour vascular normalising period for effective timing of anti-cancer drug treatment. Therefore, biomarkers delineating this window are essential,” explained Nobuyuki Takakura, Professor at Research Institute for Microbial Diseases, Osaka University.

Also Read: What We Know About Cancer Risk and Coffee

Angiogenesis therapy is clinically used to suppress tumour growth. Adding an anti-angiogenic drug can boost an anticancer drug’s effectiveness. Basic research indicates that anti-angiogenic therapy allows the blood vessels to return to quiescence and “normalise” so that the anti-cancer drug can penetrate the tumour more effectively. IANS

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High carbohydrate intake may increase cancer recurrence risk

Five-year survival rates among these patients continue to be low, in part because these cancers are often detected in the later stages

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Can sugar contribute to growth of cancer in your body? Pixabay

Consuming high amounts of carbohydrates and sugar prior to treatment for head and neck cancer may increase the patients’ risks of cancer recurrence and mortality, a new study reports.

Patients who consumed the most total carbohydrates and sugars — in the form of sucrose, fructose, lactose and maltose — in the year preceding the cancer treatment were at greater risk of mortality from any cause during the follow-up period. Out of the 400 cancer patients in the study, published in the International Journal of Cancer, more than 17 per cent experienced recurrence of their cancer, and 42 patients died from it.

protein
Cancer can be caused by excessive intake of sugar and carbohydrates too. Pixabay

Associations among carbohydrate intake and patient outcomes differed by cancer type and stage, said lead author Anna E. Arthur, professor at the University of Illinois at Urbana-Champaign.

However, eating moderate amounts of fats and starchy foods such as whole grains, potatoes and legumes after treatment could have protective benefits, reducing the patients’ risks of disease recurrence and death, he added.

What We Know About Cancer Risk and Coffee

“Our results, along with the findings of other studies, suggest that diet composition can affect cancer outcomes,” said co-author Amy M. Goss, professor at the University of Alabama.

Higher mortality rates were found among people with oral cavity cancer who consumed the greatest amounts of total carbohydrates, total sugars and simple carbohydrates, but the researchers found no such associations among people who had oropharyngeal cancers.

Chronic diseases are not yet included in cancer prevention schemes.
Cancer can be caused due to too much sugar.

“Although in this study we found that higher total carbohydrate and total sugar were associated with higher mortality in head and neck cancer patients, because of the study design we can’t say that there’s a definitive cause-effect relationship,” Arthur said.

Five-year survival rates among these patients continue to be low, in part because these cancers are often detected in the later stages, putting patients at high risk of recurrence, the researchers said. IANS

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