Thursday January 17, 2019

New Biomarker Helps Identify Cancer Chemotherapy Timing

Angiogenesis therapy is clinically used to suppress tumour growth. Adding an anti-angiogenic drug can boost an anticancer drug's effectiveness

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Biomarker can be used to decide timing fro chemotherapy.

In ray of hope for doctors to identify the tumour normalising period for effective timing of anti-cancer drug treatment, a team of researchers have discovered a new biomarker that can visualise the activity of blood vessels.

Angiogenesis, the formation of new blood vessels, is essential for tumour growth. The team from Osaka University in Japan, in a paper reported in The American Journal of Pathology, described a vascular stabilization biomarker that can visualize blood vessel activity, thus optimising the timing of anticancer therapies including anti-angiogenics.

Chronic diseases are not yet included in cancer prevention schemes.
This can help cancer patients greatly.

Combination therapy using angiogenesis inhibitors and anticancer drugs can improve drug delivery into tumour tissues and prolong progression-free survival. “Vascular normalisation by angiogenesis inhibitors, such as vascular endothelial growth factor (VEGF) signaling inhibitors, is a promising method for improvement of chemotherapy.

“However, it is unclear how we can recognise the ‘window of opportunity’ for the tumour vascular normalising period for effective timing of anti-cancer drug treatment. Therefore, biomarkers delineating this window are essential,” explained Nobuyuki Takakura, Professor at Research Institute for Microbial Diseases, Osaka University.

Also Read: What We Know About Cancer Risk and Coffee

Angiogenesis therapy is clinically used to suppress tumour growth. Adding an anti-angiogenic drug can boost an anticancer drug’s effectiveness. Basic research indicates that anti-angiogenic therapy allows the blood vessels to return to quiescence and “normalise” so that the anti-cancer drug can penetrate the tumour more effectively. IANS

Next Story

Risk Of Suicide Quadruples With Cancer: Study

The results could be used to help identify patients who may be at a higher risk for suicide and help health care providers tailor their treatments accordingly.

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A Family In Delhi Commits Suicide To Thank God: Police Reports
While the risk of suicide decreases five years after a diagnosis, the risk remains high for patients with Hodgkin lymphoma and testicular cancer.

People with cancer are over four times more likely to commit suicide than people without the deadly disease, finds a study.

According to researchers from the Penn State Cancer Institute in Pennsylvania, while a lot of progress has been made in treating cancer, not as much research has been put into how cancer affects patients mentally and emotionally.

“Even though cancer is one of the leading causes of death, most cancer patients do not die from cancer, the patients usually die of another cause,” said Nicholas Zaorsky, radiation oncologist at the Penn State Cancer Institute.

“There are multiple competing risks for death, and one of them is suicide. Distress and depression can arise from cancer diagnosis, treatment, financial stress, and other causes. Ultimately, distress and depression may lead to suicide. Our goal was to quantify the risk of suicide among cancer patients,” he added.

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The study, published in the Nature Communications journal, the team compared the risk of suicide in eight million patients who had been diagnosed with cancer and those without.

They found that among people with cancer, males, patients who were diagnosed at a younger age, patients with lung, head, neck and testicular cancer, and lymphomas were more likely to commit suicide.

While the risk of suicide decreases five years after a diagnosis, the risk remains high for patients with Hodgkin lymphoma and testicular cancer.

“Treatments for some cancers — like leukemia and testicular cancer among adolescents and young adults, for example — can decrease a patient’s fertility, and that seems to be one of the risks for suicide in the long term,” Zaorsky said.

Also Read: Here’s What Causes Cancer in Children

“In contrast, elderly patients who are diagnosed with lung, prostate and head and neck cancers, are at an increased risk of suicide for the remainder of their life.”

The results could be used to help identify patients who may be at a higher risk for suicide and help health care providers tailor their treatments accordingly. (IANS)