Saturday, July 4, 2020
Home Life Style Health & Fitness Blood Cancer: Stem Cell Protein Play An Important Role in Cure

Blood Cancer: Stem Cell Protein Play An Important Role in Cure

The stem cell protein Asrij is misexpressed in several human hematological malignancies and implicated in the p53 pathway and DNA damage response, the team said.

Researchers have identified a stem cell protein that may help in finding cure for blood cancer.

The study, done on mice, suggests a stem cell protein called Asrij is a novel regulator of wild type tumour suppressor p53 stability in hematopoietic stem cells (HSCs).

cancer
According to the study, published in the journal Blood, inactivation of the tumour suppressor p53 is essential for unrestrained growth of cancers. But only 11 per cent of hematological malignancies have mutant p53. Pixabay

It could help design targeted therapies for myeloproliferative disease, a group of slow-growing blood cancers, according to researchers, including Maneesha S. Inamdar from the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) in Bengaluru.

“We provide a new mouse model resembling myeloproliferative disease and identify a post-translational regulator of wild type p53 essential for maintaining HSC quiescence that could be a potential target for pharmacological intervention,” the team said.

According to the study, published in the journal Blood, inactivation of the tumour suppressor p53 is essential for unrestrained growth of cancers. But only 11 per cent of hematological malignancies have mutant p53.

microscope
The study, done on mice, suggests a stem cell protein called Asrij is a novel regulator of wild type tumour suppressor p53 stability in hematopoietic stem cells (HSCs). Pixabay

Mechanisms that cause wild type p53 dysfunction and promote leukemia are inadequately deciphered, suggests the study.

Also Read: How is Media Effecting Political Situations in India Today?

The stem cell protein Asrij is misexpressed in several human hematological malignancies and implicated in the p53 pathway and DNA damage response, the team said.

For the study, the team generated the first Asrij null (knockout, KO) in mice and showed they are viable and fertile with no gross abnormalities. However, by six months, they exhibited increased peripheral blood cell counts, splenomegaly and an expansion of bone marrow HSCs with higher myeloid output. (IANS)

 

 

STAY CONNECTED

19,001FansLike
362FollowersFollow
1,779FollowersFollow

Most Popular

Facebook, Instagram to Encourage Users to Wear Face Masks in US

Both Facebook and Instagram will now show an alert on top of the News Feed to encourage users to wear face masks in the...

DIY Tools, Products See a 90% Sale Rise

Indians seem to be completing minor home repairs themselves as they limit outsider entry into their interior spaces, as an e-commerce platform sees fast...

Everything You Need to Know About Pro-Touring

If you hang around car enthusiasts for long enough, there are certain words you become familiar with. Now, being familiar with a word doesn't...

Skincare Essentials Everyone Should Have This Monsoon

Monsoon takes a toll on your skin and hair. Frizzy hair, lackluster skin, and chapped lips are all a result of the humidity. Whether...

Indian Origin Cardiologist Agrees to Pay $400K to Settle False Allegations

By Arul Louis An Indian origin cardiologist and the administrator of her company have agreed to pay $400,000 to settle allegations that they submitted irregular...

Early Marriage is Found to be Unhappy, Says Research

Want to get married at a very young age? Kindly take note. Researchers have found that early marriage may lead to unsafe drinking behavior...

Essential Facts and Details about the Vedas That Pertain To Hindu Dharma

Vedas have influenced ancient Indian society greatly and have become a crucial part in the forming of the Hindu dharma. Although the knowledge the...

PETA Starts Campaign to Stop Sacrifice of Goats on Bakra Eid

A month before the festival of Bakra Eid, the People for the Ethical Treatment of Animals (PETA) India has started a campaign to stop...

Recent Comments