Sunday, January 24, 2021
Home Life Style Health & Fitness Blood Cancer: Stem Cell Protein Play An Important Role in Cure

Blood Cancer: Stem Cell Protein Play An Important Role in Cure

The stem cell protein Asrij is misexpressed in several human hematological malignancies and implicated in the p53 pathway and DNA damage response, the team said.

Researchers have identified a stem cell protein that may help in finding cure for blood cancer.

The study, done on mice, suggests a stem cell protein called Asrij is a novel regulator of wild type tumour suppressor p53 stability in hematopoietic stem cells (HSCs).

cancer
According to the study, published in the journal Blood, inactivation of the tumour suppressor p53 is essential for unrestrained growth of cancers. But only 11 per cent of hematological malignancies have mutant p53. Pixabay

It could help design targeted therapies for myeloproliferative disease, a group of slow-growing blood cancers, according to researchers, including Maneesha S. Inamdar from the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) in Bengaluru.

“We provide a new mouse model resembling myeloproliferative disease and identify a post-translational regulator of wild type p53 essential for maintaining HSC quiescence that could be a potential target for pharmacological intervention,” the team said.

According to the study, published in the journal Blood, inactivation of the tumour suppressor p53 is essential for unrestrained growth of cancers. But only 11 per cent of hematological malignancies have mutant p53.

microscope
The study, done on mice, suggests a stem cell protein called Asrij is a novel regulator of wild type tumour suppressor p53 stability in hematopoietic stem cells (HSCs). Pixabay

Mechanisms that cause wild type p53 dysfunction and promote leukemia are inadequately deciphered, suggests the study.

Also Read: How is Media Effecting Political Situations in India Today?

The stem cell protein Asrij is misexpressed in several human hematological malignancies and implicated in the p53 pathway and DNA damage response, the team said.

For the study, the team generated the first Asrij null (knockout, KO) in mice and showed they are viable and fertile with no gross abnormalities. However, by six months, they exhibited increased peripheral blood cell counts, splenomegaly and an expansion of bone marrow HSCs with higher myeloid output. (IANS)

 

 

STAY CONNECTED

19,120FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

Bilingual Homes Makes The Child More Attentive

 If your child grew up speaking two different languages, it can shift your attention between different tasks quicker than those who pick up a...

Yerwada Jail Is Now Unlocked For Tourists

Marking a new chapter for tourists, the Maharashtra government will throw open important prisons in the state for 'jail tourism', starting this Republic Day...

Mountain Kilimanjaro Is Scaled By A Telangana IPS Officer

The Indian Police Service IPS official reached the top of Mountain Kilimanjaro, 5,895 meters above sea level, on January 21 at 08.15 a.m. (local...

Amit Shah Claims North East Has The Potential To Become A Tourist Hub

Union Home Minister Amit Shah on Saturday said that the central government led by Prime Minister Narendra Modi is leaving no stone unturned in...

Swara Bhasker Says That The Idea Is To Try Things One Hasn’t Done Before

Actress Swara Bhasker has donned multiple looks in her new web series, Aapkey Kamrey Mein Koi Rehta Hai, and she says trying different things...

How Financial Institutions Assess Your Financial Health And What You Can Do To Improve It

Everyone works hard to make the right financial decisions in their lives. Doing so involves adopting practices like saving money and making secure investments....

7 Great Teachings Of Guru Acharya Chanakya

BY SHWETA PORWAL Chanakya, traditionally identified as Kautilya or Vishnugupta was born in the 3rd century BC (350-275 BC) in Patliputra. Chanakya was born to...

CT Helps Catch Liver Disease

Researchers have identified that multiple CT findings can identify patients with high-risk non-alcoholic fatty liver disease (NAFLD) -- advanced fibrosis or cirrhosis, that is...

Recent Comments