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Researchers have found that a simple Blood Test can detect Breast Cancer up to five years before there are any clinical signs of it.
The blood test identifies the body’s immune response to substances produced by tumour cells, according to the research presented at the 2019 NCRI (National Cancer Research Institute) Cancer Conference in Glasgow, UK, on Sunday.
“We need to develop and further validate this test,” said Daniyah Alfattani from University of Nottingham in Britain.
“However, these results are encouraging and indicate that it’s possible to detect a signal for early breast cancer. Once we have improved the accuracy of the test, then it opens the possibility of using a simple blood test to improve early detection of the disease,” she said.
Cancer cells produce proteins called antigens that trigger the body to make antibodies against them — auto-antibodies.
The researchers have found that these tumour-associated antigens (TAAs) are good indicators of cancer, and now they have developed panels of tumour-associated antigens that are known already to be associated with breast cancer to detect whether or not there are auto-antibodies against them in blood samples taken from patients.
In a pilot study, the researchers took blood samples from 90 breast cancer patients at the time they were diagnosed with breast cancer and matched them with samples taken from 90 patients without breast cancer (the control group).
They used screening technology (protein microarray) that allowed them to screen the blood samples rapidly for the presence of auto-antibodies against 40 tumour-associated antigens associated with breast cancer, and also 27 tumour-associated antigens that were not known to be linked with the disease.
“The results of our study showed that breast cancer does induce autoantibodies against panels of specific tumour-associated antigens. We were able to detect cancer with reasonable accuracy by identifying these auto-antibodies in the blood,” Alfattani said while presenting the research.
The researchers identified three panels of tumour-associated antigens against which to test for autoantibodies. The accuracy of the test improved in the panels that contained more tumour-associated antigens.
The panel of five tumour-associated antigens correctly detected breast cancer in 29 per cent of the samples from the cancer patients and correctly identified 84 per cent of the control samples as being cancer-free.
The panel of seven tumour-associated antigens correctly identified cancer in 35 per cent of cancer samples and no cancer in 79 per cent of control samples. The panel of nine antigens correctly identified cancer in 37 per cent of cancer samples and no cancer in 79 per cent of the controls.
The researchers are now testing samples from 800 patients against a panel of nine tumour-associated antigens, and they expect the accuracy of the test to improve with these larger numbers.
“A blood test for early breast cancer detection would be cost effective, which would be of particular value in low and middle income countries. It would also be an easier screening method to implement compared to current methods, such as mammography,” said Alfattani. (IANS)
By Olivia Sarkar
Comforting Christmas cocktails help you enjoy the celebrations and get into the festive spirit. The Leela Palaces, Hotels, and Resorts offer distinctive cocktails ranging from Hot Toddies to Decadent Egg Nogs. Sit back and enjoy one martini at a time to make the festive season a little brighter.
Dirty Chai Eggnog:
30 ml Bourbon
30 ml Baileys
90 ml Hot milk tea
Sweet cream foam to top up
Cinnamon powder and star anise.
1. In a heavy bottomed med sauce pot, prepare tea with milk. Strain and let it cool.
2. In a cocktail shaker add egg white, Bourbon, Baileys with whole spices. Shake well.
3. Pour the tea in the glass followed by ingredients from cocktail shaker.
4. Garnish with nutmeg and cinnamon powder, whole star anise
Eggnog is a Christmas favourite that is accustomed to toasts for good health and prosperity.| Pikist
Inspired by the Christmas Spirits and holiday flavours is a wonderful concoction of warm whisky, sweet vanilla, and thick butter.
45 ml Butter fat washed Whiskey
20 ml Ginger bread syrup
15 ml Spiced Apple liquor
2 dashes of Bitters
1/2 teaspoon Vanilla extract
1. Pour all ingredients into a cocktail shaker
2. Shake well
3. Pour into an old-fashioned glass
4. Garnish with Gingerbread cookie
Inspired by the Christmas Spirits and holiday flavors is a wonderful concoction of warm whisky, sweet vanilla, and thick butter. | Flickr
(Keywords: Santa's Apple, Egg Nogs, December, Cocktail, Cocktail, Christmas, holiday, celebrations)
Probiotics may significantly improve the symptoms of pregnancy-related nausea, vomiting and constipation, finds a new study.
The study, published in the journal Nutrients, showed that nausea hours (the number of hours participants felt nauseous) were reduced by 16 per cent, and the number of times they vomited was reduced by 33 per cent.
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Probiotic intake also significantly improved symptoms related to the quality of life, such as fatigue, poor appetite and difficulty maintaining normal social activities, as scored by questionnaires.
"The cause of nausea and vomiting during pregnancy is unknown to this date. Various theories have been proposed, but none of them is conclusive," said lead author Albert T. Liu from the University of California, Davis.
Also Read : Changes in the Skin during Pregnancy
"Nausea, vomiting and constipation during pregnancy can significantly diminish the quality of patients' lives. Once nausea and vomiting during pregnancy progress, they can become difficult to control, and sometimes the patient even needs to be hospitalized," Liu added.
For the study, the team involved a small yet significant number of participants who took a probiotic capsule twice a day for six days and then took two days off. They then repeated the cycle.
The team found that probiotics were also found to reduce constipation significantly.Unsplash
The probiotics were available over-the-counter and mainly contained Lactobacillus., a type of good bacteria. Each capsule contained approximately 10 billion live cultures at the time of manufacture.
Participants kept 17 daily observations of their symptoms during the duration of the study, for a total of 535 observations for the researchers to statistically assess.
The team found that probiotics were also found to reduce constipation significantly.
Another finding was that vitamin E levels increased after taking probiotics. Higher levels of vitamin E were associated with low vomiting scores. (IANS/SP)
(Keywords : probiotics, pregnancy, nausea, vomiting, nutrients, symptoms, fatigue, appetite, constipation, vitamin.)
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By Olivia Sarkar
If the year 2020 appeared bleak for the world, the year 2021 served as a frightening reminder that it wasn't so much about the year as it was about the times we've come to live in. Every domain and industry has experienced seismic shifts, both for the better and for the bad. However, just a few fields have seen such a huge paradigm shift as online dating throughout the course of 2021.
It becomes critical to document and analyse the important observations in the year 2021's dating trends in order to determine where online dating stands and where it is headed. This is where a poll conducted by one of India's popular dating apps, QuackQuack, comes in handy. "The pandemic has undoubtedly thrown a few curveballs towards folks wanting to date," remarked Mr. Ravi Mittal, Founder and CEO of QuackQuack, in response to the survey report. Males and females, in my opinion, are fast coming to terms with a new universe of online dating every day, adopting more self-paced and healthier forms of dating, a growing process that will soon become the standard."
The key takeaways from the survey can be best summarized as below:
- Vaccination is a must: An overwhelming 8 out of 10 persons in the survey's sample size expressed support for mandatory vaccination as a prerequisite to a date. A considerable 65 per cent and 75 per cent of people in the 18-20 and 21-30 age categories, respectively, agreed on the same thing. The need of a double jab was consistently emphasized across the country's top cities and tier 2 cities, with 75 per cent and 70 per cent of the sample size in each believing that the first step toward a safe date would have to be complete immunization of the other.
An overwhelming 8 out of 10 persons in the survey's sample size expressed support for mandatory vaccination as a prerequisite to a date. | Photo by CDC on Unsplash
- Dating with a purpose: The poll revealed that, because of the Covid procedures in place, people have had little motivation to walk outside, leading them to think on the nature of the dates they've discovered on the dating app rather than searching for matches in a desperate manner. The survey found that 47 per cent of women and 35 per cent of men agreed with this behavioral change, and that the act of reflection and introspection allowed them to have healthier relationships than before.
The difference in deliberate dating trends between people who live in cities and those who live in rural or semi-urban settings was quite similar. While roughly 37 per cent of urban teenagers believed their dating experience had taken an intentional turn, 39 per cent of rural or semi-urban teenagers felt the same way.
The difference in deliberate dating trends between people who live in cities and those who live in rural or semi-urban settings was quite similar. | Photo by René Ranisch on Unsplash
- Location is pivotal: According to the survey, a whopping 58 per cent and 56 per cent of people between the ages of 18 and 20 and 21 and 30 preferred hooking up with someone from a different place to broaden their search for a potential spouse. This trend proved to be more prevalent among women, as 58 per cent of them were comfortable dating partners from foreign countries, compared to only 50 per cent of men. Further study into a demographic analysis of the sampled data found that 46 per cent of those living in major metro cities preferred dating outside of their home location, while 57 per cent of those living in smaller cities and towns favored the same.
According to the survey, a whopping 58 per cent and 56 per cent of people between the ages of 18 and 20 and 21 and 30 preferred hooking up with someone from a different place to broaden their search for a potential spouse. | Pixabay
- Video calling versus meeting in person: Due to the ongoing Covid problem across the country, a large majority of 56 per cent of 18 to 20-year-olds preferred having their first date on a virtual medium and were risk-averse, according to the survey. On the other hand, 43 per cent of persons aged 30 and up, who adhere to a more traditional approach, decided to meet in person while taking all essential safety steps.
43 per cent of persons aged 30 and up, who adhere to a more traditional approach, decided to meet in person while taking all essential safety steps. | Photo by Matt W Newman on Unsplash
According to the survey, a vast majority of 56 per cent of 18 to 20-year-olds preferred having their first date on a virtual medium and were risk-averse due to the ongoing Covid crisis across the country. In contrast, 43 per cent of people aged 30 and up who prefer a more traditional approach preferred to meet in person while following all necessary safety precautions according to the survey. (IANS/ MBI)
(Keywords: meeting, Video calling, Location, Vaccination, dating trends, 2021, Online Dating)