Wednesday July 18, 2018

New blood test can detect early signs of Alzheimer’s

The blood test would thus offer an opportunity to identify those at risk and may thereby open the door to new avenues in drug discovery

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Alzheimer Disease. IANS
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Raising hopes for an effective intervention in diagnosing the risk of early onset of disease, German scientists have developed a new blood test that can detect Alzheimer’s long before the first symptoms appear in patients.

Alzheimer’s disease is thought to begin long before patients show typical symptoms like memory loss.The team, led by Klaus Gerwert, professor at Ruhr University Bochum in Germany, noted that one of the hallmarks of Alzheimer’s disease is the accumulation of amyloid-beta plaques in the patient’s brain.

Diabetes drug can help people with alzheimer's disease and other kind of dementia
Alzheimer’s can now be detected using a blood test.Pixabay

The findings, published in the journal EMBO Molecular Medicine, showed that the blood test uses a technology called immuno-infrared sensor to measure distribution of pathological and healthy structures of amyloid-beta in the blood.

The pathological amyloid-beta structure is rich in a sticky, sheet-like folding pattern that makes it prone to aggregation, while the healthy structure is not.

Also Read: Can A Beetroot Compound Prevent Alzheimer’s?

The two structures absorb infrared light at a different frequency, allowing the blood test to determine the ratio of healthy to pathological amyloid-beta in the sample.

The pathological form is a misfolded version of this molecule and known to initiate the formation of toxic amyloid-beta molecules that starts accumulating in the brain 15 to 20 years before disease onset.

They found that the test reliably detected amyloid-beta alterations in the blood of participants with mild cognitive impairment that also showed abnormal amyloid deposits in brain scans. In order to detect blood changes well ahead of disease onset, the researchers compared blood samples of 65 participants that were later in the follow-up studies diagnosed with Alzheimer’s disease with 809 controls.

This can be very beneficial for potential Alzheimer’s patients. Flickr

The assay was able to detect signs of the disease on average eight years before diagnosis in individuals without clinical symptoms with an overall diagnostic accuracy of 86 per cent. The blood test would thus offer an opportunity to identify those at risk and may thereby open the door to new avenues in drug discovery, the researchers said. IANS

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Scientists Track ‘Ghost Particle’ to Source for First Time

The blazar that is considered the source of the neutrino was named TXS 0506+056 and is believed to be the first known source of a high-energy neutrino

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This artist's impression of the active galactic nucleus shows the supermassive black hole at the center of the accretion disk sending a narrow high-energy jet of matter into space, perpendicular to the disc in this image by Science Communication Lab in Kiel, Germany, released on July 12, 2018. In a study published in the journal Science, researchers have determined that a supermassive black hole like this one is the source of high-energy neutrinos detected on Earth. (VOA)

Scientists have announced a new finding about the source of a high-energy neutrino, a subatomic particle detected at an observatory at the Earth’s South Pole.

The study, published Thursday in the journal Science, details the work of more than 1,000 scientists who pooled their research on the tiny particles, which are able to pass through matter in a straight line — like a ghost.

The neutrino’s ability to travel without deviation from its course means its source can be accurately tracked, unlike other types of subatomic particles that can be dragged off course by a magnetic field like the Earth’s.

“[Neutrinos are] very clean, they have simple interactions, and that means every single neutrino interaction tells you something,” said Heidi Schellman, a particle physicist at Oregon State University.

Also Read: Scientists Develop Potential Approach to Treat Dementia, Stroke

The scientists used a large observatory known as IceCube, in use since 2010, to hunt for neutrinos and try to track the source. A group of neutrinos coming from the same location over the past couple of years was determined to have emanated from a blazar, or black hole that aims a jet of radiation at Earth. The black hole is estimated to have been in a distant galaxy that destructed four billion years ago.

The blazar that is considered the source of the neutrino was named TXS 0506+056 and is believed to be the first known source of a high-energy neutrino.

The discovery could be a breakthrough for multimessenger astronomy, where scientists look at the entire electromagnetic spectrum and pool their findings, using known relationships between types of electromagnetic particles to put together a larger picture.

“It is an entirely new means for us to learn about the cosmos,” Roopesh Ojha of NASA’s Goddard Space Flight Center told The Washington Post. (VOA)

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