Monday March 30, 2020

Blood Test Can Predict Onset of Tuberculosis, Says Study

For this study, researchers initially conducted a systematic review of published gene signatures found to be present in blood samples from people with TB, compared to healthy individuals

0
//
Blood Test
For the findings, published in the journal Lancet Respiratory Medicine, researchers at University College London sought to identify which, if any, gene expression signatures in blood could be used to predict the disease at a very early stage and before symptoms. Pixabay

Researchers, including one of Indian-origin, have revealed a blood test could predict the onset of tuberculosis three to six months before people become unwell, a finding which could help better target antibiotics and save countless lives.

For the findings, published in the journal Lancet Respiratory Medicine, researchers at University College London sought to identify which, if any, gene expression signatures in blood could be used to predict the disease at a very early stage and before symptoms

Gene expression signatures are single or combined measurements of levels of specific gene products and are being tested in a range of diseases to aid diagnosis, prognosis or prediction of the response to treatment.

Some are already being used to support the management of cancers, but none have reached the clinic in infectious diseases, such as tuberculosis (TB).

“Our findings establish the gene signatures in blood which show most promise for identifying people who are at risk of disease,” said study author Mahdad Noursadeghi, Professor at University College London.

“Future development of a blood test based on these findings could make an important contribution to efforts to reduce the impact and spread of this deadly infection,” Noursadeghi added.

For this study, researchers initially conducted a systematic review of published gene signatures found to be present in blood samples from people with TB, compared to healthy individuals.

From this, 17 candidate gene expression signatures for TB were identified, and tested in more than 1,100 blood samples in published data sets from South Africa, Ethiopia, The Gambia, and the UK. Scientists analysed samples from people who had no TB symptoms at the time they gave blood.

Those people were then followed up to identify which participants developed TB in the subsequent months.

Researchers found that eight of these signatures, including measurement of expression of a single gene, could predict the diagnosis of TB within three to six months, which falls within the accuracy required by the World Health Organisation (WHO) for new diagnostic tests.

This accuracy was achieved, by revealing the patients’ immune responses to bacteria before the symptoms of the disease develop.

Blood Test
Researchers, including one of Indian-origin, have revealed a blood test could predict the onset of tuberculosis three to six months before people become unwell, a finding which could help better target antibiotics and save countless lives. Pixabay

“The emergence of gene expression signature tests, which can aid diagnosis and early treatment, provides real hope for the management of infectious diseases,” said Indian-origin researcher and the study’s lead author Rishi Gupta.

“In this study we identify multiple signatures to identify the onset of tuberculosis, which is extremely encouraging, potentially providing multiple targets for early detection,” Gupta added.

ALSO READ: “We Are Prepared To Face Novel Coronavirus”, Says MakeMyTrip CEO Deep Kalra

Further development of these tests could help identify people who will benefit most from preventative antibiotic treatment, in order to reduce the occurrence of tuberculosis, the researchers said. (IANS)

Next Story

Here Are Some Health-Boosting Beverages Which You Can Try

Want to have a quick, refreshing drink that also boosts your health and immunity? Look no further

0
Beverages
Beverages can make you feel refreshed and energized. Pixabay

Want to have a quick, refreshing drink that also boosts your health and immunity? Look no further, these recipes don’t come out of a bottle and are healthier options suggests Chef Ayesha Nallaseth, Culinary Product Specialist, Tupperware India.

Banana Walnut Shake

Ingredients:

Half tropical cup banana,
peeled and quartered
1 cup milk
2 tbsp walnuts
chopped
4-5 ice cubes
Honey to drizzle

Method: Chop the banana and walnut. Add the mixture to Tupperware Quick Shake, pour milk, honey and ice cubes and shake well till well incorporated and serve immediately.

Tip: Complete food for the nerves, muscle, immunity and brain to save them from damage and boost recovery.

Ultimate Green Smoothie

Ingredients:

1 cup soy milk/almond milk
1 cup spinach leaves
1 banana
1 tbsp peanut butter

Breakfast Drink, Almond, Cocoa, Nibs, Shake, Banana
Healthy beverages may actually boost your immunity and help you stay fit in long run. Pixabay

Method: Add the spinach leaves banana and peanut butter and finely chop. Add ice cubes to quick shake add the above mix and soy or almond milk and shake well. Serve chilled.

Kahwa tea

Ingredients:

2 cups water
1 Tsp tea leaves
2 tsp sugar
4 green cardamom
1 pc Cinnamon stick,
4 to 5 strands saffron (optional)

ALSO READ: Researchers Develop New Framework To Select Best Trees For Fighting Air Pollution

Method: Boil water add the tea leaves and sugar and strain and pour it in the flask. Then add the cardamom, cinnamon sticks and saffron strands.

Close the flask. Serve using smidgets as a welcome drink. (IANS)