Saturday November 23, 2019

Breast Cancer Drugs may Force Some Cancer Cells into ‘Sleeper Mode’

The team studied human breast cancer cells in the laboratory and examined the effects of a group of breast cancer drugs called hormone treatments

0
//
Breast Cancer, Drugs, Cells
The research could open avenues for finding ways of keeping the cancer cells dormant for longer, or even potentially finding a way of awakening the cells so they can then be killed by the treatment. Pixabay

Breast cancer drugs may force some cancer cells into ‘sleeper mode’, allowing them to potentially come back to life years after initial treatment.

The research could open avenues for finding ways of keeping the cancer cells dormant for longer, or even potentially finding a way of awakening the cells so they can then be killed by the treatment.

The team studied human breast cancer cells in the laboratory and examined the effects of a group of breast cancer drugs called hormone treatments.

“For a long time scientists have debated whether hormone therapies – which are a very effective treatment and save millions of lives – work by killing breast cancer cells or whether the drugs flip them into a dormant ‘sleeper’ state,” said Luca Magnani, lead author of the study from Imperial College London.

Breast Cancer, Drugs, Cells
Breast cancer drugs may force some cancer cells into ‘sleeper mode’, allowing them to potentially come back to life years after initial treatment. Pixabay

“This is an important question as hormone treatments are used on the majority of breast cancers. Our findings suggest the drugs may actually kill some cells and switch others into this sleeper state,” Magnani added.

“If we can unlock the secrets of these dormant cells, we may be able to find a way of preventing cancer coming back, either by holding the cells in permanent sleep mode, or be waking them up and killing them,” Magnani said.

In the study, published in the journal Nature Communications, the team studied around 50,000 human breast cancer single cells in the lab, and found that treating them with hormone treatment exposed a small proportion of them as being in a dormant state.

The ‘sleeper cells’ may also provide clues as to why some breast cancer cells become resistant to treatment, causing a patient’s drugs to stop working, and their cancer to return, the researchers said.

Also Read- Killer Gorge in Hell’s Gate National Park Closed after 7 killed

Hormone therapies are used to treat a type of breast cancer called oestrogen-receptor positive. These make up over 70 per cent of all breast cancers, and are fuelled by the hormone oestrogen.

These cancers are usually treated with surgery to remove the tumour, followed by a course of targeted hormone therapy – usually either aromatase inhibitors or tamoxifen, which target oestrogen receptors.

However, around 30 per cent of breast cancer patients taking hormone therapies see their cancer eventually return – sometimes as long as 20 years after treatment.

This returning cancer is usually metastatic, meaning it has spread around the body, and the tumours are often now resistant to medication. (IANS)

Next Story

Researchers Find That Discount on Medical Drugs Can Make you Purchase Them More

The study used Canadian national pharmacy data from 2.82 million prescriptions for 89 different medications where brand-name drug discount cards were used and compared

0
Discount
While Discount cards decreased some patients' out-of-pocket costs by 7 per cent on an average, the study surprisingly found that many patients who filled prescriptions using a card were worse-off financially as a result. Pixabay

Researchers have found that brand-name Drug Discount cards are leading to higher healthcare spending in Canada.

Brand-name drug discount cards — also known as co-pay cards — are coupons offered by drug manufacturers to encourage patients to use brand-name drugs even after much cheaper generics became available.

Despite often boosting savings for customers, the study’s findings published in the Canadian Medical Association Journal show that drug discount cards actually increased private insurer costs by 46 per cent and public insurer costs by 1.3 per cent, compared to patients purchasing generics instead.

“We know that generic drugs are equally effective for the vast majority of patients. Given that, I believe these cards are leading to unjustifiable increases in health care costs,” said the study’s lead author Michael Law from the University of British Columbia in Canada.

While discount cards decreased some patients’ out-of-pocket costs by 7 per cent on an average, the study surprisingly found that many patients who filled prescriptions using a card were worse-off financially as a result.

This wasn’t the case for all drugs, but in some cases patients could pay up to $10 more out-of-pocket when using a discount card.

The study used Canadian national pharmacy data from 2.82 million prescriptions for 89 different medications where brand-name drug discount cards were used and compared the costs of these prescriptions to matched generic equivalents.

Discount
Researchers have found that brand-name Drug Discount cards are leading to higher healthcare spending in Canada. Pixabay

The researchers said that patients, their clinicians and employers should be aware of the impact that brand-name discount cards have on the healthcare system.

For example, the increased costs to private insurers will likely be passed on to the patients and their employers in the form of increased insurance premiums.

ALSO READ: Ram Mandir To Be Built In Ayodhya By 2022

“Regardless of whether they hold insurance, patients should check the relative price between brand-name drugs with a discount card and the equivalent generics at their pharmacy,” said Law. (IANS)