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British researchers discover a protein that can control spread of breast cancer in body

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London: British researchers have identified a key protein that can control how breast cancer cells spread in the body.

The study sheds light on how cancer cells leave the blood vessels to travel to a new part of the body, said the researchers from the University of Manchester in Britain.

When tumor cells spread, they first enter the blood stream and grip onto the inner walls of blood vessels, the researchers elicited.

The cancer cells control a receptor protein called EPHA2 in order to push their way out of the vessels, they added.

When these cancer cells interact with the walls of the blood vessels, EPHA2 is activated and the tumor cells remain inside the blood vessels. When the EPHA2 is inactive, the tumor cells can push out and spread, revealed the study published in the journal Science Signaling.

The researchers used a technique that allowed them to map how cancer cells interact and exchange information with cells that make up the blood vessels.

“The next step is to figure out how to keep this receptor switched on, so that the tumor cells can’t leave the blood vessels – stopping breast cancer spreading and making the disease easier to treat successfully,” concluded the lead researcher Claus Jorgensen from the University of Manchester. (IANS)

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Night shifts may increase cancer risk

A positive association between night shifts and risk of cancer

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Night shifts increase cancer risk. Pexels
Night shifts increase cancer risk. Pexels
  • Long-term night shift work among women increased the risk of cancer by 19%.
  • A meta-analysis using using international data from 61 articles comprising 114,628 cancer cases and 3,909,152 participants.
  • These studies found an association between long-term night shift work and risk of 11 types of cancer.

Women who work overnight have a comparatively high risk of developing cancer than women who do not, say researchers. An analysis of international data has confirmed an association between night-shifts and cancer.

“Our study indicates that night shift work serves as a risk factor for common cancers in women,” said Xuelei Ma, co-author of the study from West China Medical Center of Sichuan University in Chengdu, China.

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Findings

These studies found an association between long-term night shift work and risk of 11 types of cancer. Wikimedia commons
These studies found an association between long-term night shift work and risk of 11 types of cancer. Wikimedia commons
  • Long-term night shift work among women increased the risk of cancer by 19 percent.
  • Nurses (working in night shifts) had the highest risk of breast cancer, of all the occupations analysed.
  • The population of women working on night shifts have an increase risk of skin (41%), breast (32%) and gastrointestinal cancer (18%).
  • Among female nurses alone, those who worked the night shift had an increased risk of breast (58%), gastrointestinal (35%) and lung cancer (28%).

Methodology

  • A meta-analysis using data from 61 articles comprising 114,628 cancer cases and 3,909,152 participants from North Amercia, Europe, Australia and Asia.
  • The articles consisted of 26 cohort studies, 24 case-control studies and 11 nested case-control studies.
  • These studies found an association between long-term night shift work and risk of 11 types of cancer.

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“Nurses that worked the night shift were of a medical background and may have been more likely to undergo screening examinations,” the researcher suggested.

The results might help establish and implement effective measures to protect female night shifters. Pixabay
The results might help establish and implement effective measures to protect female night shifters. Pixabay

“Long-term night shift workers should have regular physical examinations and cancer screenings,” Ma noted.

The study was published in journal Cancer Epidemiology. (IANS)

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