London: British researchers have identified a key protein that can control how breast cancer cells spread in the body.
The study sheds light on how cancer cells leave the blood vessels to travel to a new part of the body, said the researchers from the University of Manchester in Britain.
When tumor cells spread, they first enter the blood stream and grip onto the inner walls of blood vessels, the researchers elicited.
The cancer cells control a receptor protein called EPHA2 in order to push their way out of the vessels, they added.
When these cancer cells interact with the walls of the blood vessels, EPHA2 is activated and the tumor cells remain inside the blood vessels. When the EPHA2 is inactive, the tumor cells can push out and spread, revealed the study published in the journal Science Signaling.
The researchers used a technique that allowed them to map how cancer cells interact and exchange information with cells that make up the blood vessels.
“The next step is to figure out how to keep this receptor switched on, so that the tumor cells can’t leave the blood vessels – stopping breast cancer spreading and making the disease easier to treat successfully,” concluded the lead researcher Claus Jorgensen from the University of Manchester. (IANS)
Eating natural yogurt daily may lesson breast cancer risk owing to lactose fermenting bacteria which reduces inflammation triggered by harmful bacteria, say researchers.
Yoghurt contains beneficial lactose-fermenting bacteria commonly found in milk, similar to the bacteria — or microflora 00 found in the breasts of mothers who have breastfed.
Scientists from Lancaster University said their idea — as yet unproven — is supported by the available evidence, which is that bacterial induced inflammation is linked to cancer.
“There is a simple, inexpensive potential preventive remedy; which is for women to consume natural yoghurt on a daily basis,” the authors wrote in a paper appeared in the journal Medical Hypotheses.
“We now know that breast milk is not sterile and that lactation alters the microflora of the breast,” said Dr Rachael Rigby from Lancaster University’s Faculty of Health and Medicine.
“Lactose fermenting bacteria are commonly found in milk and are likely to occupy the breast ducts of women during lactation and for an unknown period after lactation,” Rigby added.
The researchers suggest that lactose-fermenting bacteria in the breast is protective because each year of breast-feeding reduces the risk of breast cancer by 4.3 per cent.
Several studies have shown that the consumption of yoghurt is associated with a reduction in the risk of breast cancer, which the researchers suggest may be due to the displacement of harmful bacteria by beneficial bacteria.
There are approximately 10 billion bacterial cells in the human body and while most are harmless, some bacteria create toxins that trigger inflammation in the body.
Chronic inflammation destroys the harmful germs but it also damages the body.
One of the most common inflammatory conditions is gum disease or periodontitis which has already been linked to oral, oesophageal, colonic, pancreatic, prostatic and breast cancer.
“The stem cells which divide to replenish the lining of the breast ducts are influenced by the microflora, and certain components of the microflora have been shown in other organs, such as the colon and stomach, to increase the risk of cancer development,” said the researchers.