London: British researchers have identified a key protein that can control how breast cancer cells spread in the body.
The study sheds light on how cancer cells leave the blood vessels to travel to a new part of the body, said the researchers from the University of Manchester in Britain.
When tumor cells spread, they first enter the blood stream and grip onto the inner walls of blood vessels, the researchers elicited.
The cancer cells control a receptor protein called EPHA2 in order to push their way out of the vessels, they added.
When these cancer cells interact with the walls of the blood vessels, EPHA2 is activated and the tumor cells remain inside the blood vessels. When the EPHA2 is inactive, the tumor cells can push out and spread, revealed the study published in the journal Science Signaling.
The researchers used a technique that allowed them to map how cancer cells interact and exchange information with cells that make up the blood vessels.
“The next step is to figure out how to keep this receptor switched on, so that the tumor cells can’t leave the blood vessels – stopping breast cancer spreading and making the disease easier to treat successfully,” concluded the lead researcher Claus Jorgensen from the University of Manchester. (IANS)
Researchers have found that women who use permanent hair dye and chemical hair straighteners have a higher risk of developing breast cancer than women who don’t use these products.
The study, published in the International Journal of Cancer, suggests that this risk increased with more frequent use of these chemical hair products.
“Researchers have been studying the possible link between hair dye and cancer for a long time, but results have been inconsistent,” said study author Alexandra White from National Institute of Environmental Health Sciences (NIEHS) in US.
“In our study, we see a higher risk associated with hair dye use, and the effect is stronger in African American women, particularly those who are frequent users,” White said.
Using data from 46,709 women in the Sister Study, researchers at NIEHS, found that women who regularly used permanent hair dye in the year prior to enrolling in the study were nine per cent more likely than women who didn’t use hair dye to develop breast cancer.
Among African American women, using permanent dyes every five to eight weeks or more was associated with a 60 per cent increased risk of breast cancer as compared with an eight per cent increased risk for white women.
The research team found little to no increase in breast cancer risk for semi-permanent or temporary dye use.
An intriguing finding was the association between the use of chemical hair straighteners and breast cancer.
The researchers found that women who used hair straighteners at least every five to eight weeks were about 30 per cent more likely to develop breast cancer.
While the association between straightener use and breast cancer was similar in African American and white women, straightener use was much more common among African American women, the study said.
The researchers cautioned that although there is some prior evidence to support the association with chemical straighteners, these results need to be replicated in other studies.
When asked if women should stop dyeing or straightening their hair, study co-author Dale Sandler, “We are exposed to many things that could potentially contribute to breast cancer, and it is unlikely that any single factor explains a woman’s risk.
“While it is too early to make a firm recommendation, avoiding these chemicals might be one more thing women can do to reduce their risk of breast cancer,” Sandler said.(IANS)