Saturday February 29, 2020

Know About Burnout Syndrome That Can Disturb Your Heart Rhythm

For the study, published in the European Journal of Preventive Cardiology, the researchers surveyed more than 11,000 individuals for the presence of vital exhaustion

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Heart
It is already known that exhaustion increases one's risk for cardiovascular disease, including heart attack and stroke. Pixabay

Feeling excessively tired, devoid of energy, demoralised and irritable? You may have burnout, a syndrome associated with a potentially deadly heart rhythm disturbance, say researchers, including one of Indian-origin.

“Vital exhaustion, commonly referred to as burnout syndrome, is typically caused by prolonged and profound stress at work or home, it differs from depression, which is characterised by low mood, guilt and poor self-esteem,” said study author Parveen K Garg of the University of Southern California in the US.

“The results of our study further established the harm that can be caused in people who suffer from exhaustion that goes unchecked,” Garg added.

Atrial fibrillation is the most common form of heart arrhythmia. Psychological distress has been suggested as a risk factor for atrial fibrillation, but previous studies showed mixed results. In addition, until now, the specific association between vital exhaustion and atrial fibrillation had not been evaluated.

For the study, published in the European Journal of Preventive Cardiology, the researchers surveyed more than 11,000 individuals for the presence of vital exhaustion, anger, antidepressant use and poor social support. They then followed them over a period of nearly 25 years for the development of atrial fibrillation.

Participants with the highest levels of vital exhaustion were at a 20 per cent higher risk of developing atrial fibrillation over the course of follow-up compared to those with little to no evidence of vital exhaustion.

While further study is needed to better understand the observed relationship, Garg noted that two mechanisms are likely at play. “Vital exhaustion is associated with increased inflammation and heightened activation of the body’s physiologic stress response,” he said.

“When these two things are chronically triggered that can have serious and damaging effects on the heart tissue, which could then eventually lead to the development of this arrhythmia,” the study author added.

Heart
Feeling excessively tired, devoid of energy, demoralised and irritable? You may have burnout, a syndrome associated with a potentially deadly heart rhythm disturbance, say researchers, including one of Indian-origin. Pixabay

No connections were found between anger, antidepressant use, or poor social support and development of atrial fibrillation. “It is already known that exhaustion increases one’s risk for cardiovascular disease, including heart attack and stroke. We now report that it may also increase one’s risk for developing atrial fibrillation, a potentially serious cardiac arrhythmia,” Garg said.

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“The importance of avoiding exhaustion through careful attention to – and management of – personal stress levels as a way to help preserve overall cardiovascular health cannot be overstated,” he concluded. (IANS)

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People with Damaged Livers Can Continue Medication for Diabetes

Even damaged livers can handle medicines for diabetes, BP

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Diabetes
People with diabetes, hypertension and depression might be able to continue taking life saving medications in small doses even while they heal from drug-induced liver injuries. Pixabay

People with diabetes, hypertension and depression might be able to continue taking life saving medications in small doses even while they heal from drug-induced liver injuries, suggests new research.

The findings, published in the journal Drug Metabolism and Disposition, suggests that doctors need not always make patients with drug-induced liver injury stop taking all their medications until the liver healed.

Drug-induced liver injury — when a person accidentally harms their liver by taking medications prescribed by a doctor (or occasionally over the counter drugs) — affects about almost 1 million people globally. “Doctors give patients drugs to treat diseases. No one wants their liver damaged, but it happens all the time,” said Xiaobo Zhong from the University of Connecticut in the US.

When a person takes a medication by mouth, it goes into their stomach and then to the intestines, where it is absorbed into the blood. This blood, in turn, passes first through the liver before reaching the rest of the body. The liver has enzymes that break down medicines.

But different people naturally have more or less of these enzymes. Sometimes, what could be a safe and effective dose in one person is too much for someone else who has different enzyme levels. This is why some individuals are more vulnerable to liver damage, even when taking drugs just as a doctor prescribed.

Diabetes
If patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control if they do not take their medicines. Pixabay

There is no standard guidance for doctors when a patient gets drug-induced liver damage. Often times they tell the person to stop taking all medications immediately and wait for their liver to recover. But that can take weeks or months.

“But if patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control,” if they stop taking the medications, Zhong said. And that can be life threatening.

The researchers tested whether mice whose livers had been damaged by acetaminophen (the active ingredient in Tylenol) had lower levels of drug metabolising enzymes, called cytochrome P450 enzymes.

The researchers investigated whether mice with drug-induced liver damage can safely take medications for diabetes, hypertension and depression. It looks like they can, as long as the doses are much smaller than normal, said the study.

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Because the damaged liver does not break down the medications as efficiently, they are just as effective at these lower doses. The team still has to test whether these results hold in humans. (IANS)