Sunday December 15, 2019

“The Cancer Cells Have An Unlimited Appetite For Nutrients,” said Xiaoyong Yang, Professor at Yale

Scientists at Yale Cancer Scientists have uncovered the workings of a metabolic pathway or "gauge" that lets cancer cells detect when they have enough nutrients around them to grow

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Cancer, cells, metabolism, research, treatment, science
the workings of a metabolic pathway or "gauge" that lets cancer cells detect when they have enough nutrients around them to grow.. Pixabay

Scientists at Yale Cancer Scientists at Yale Cancer Center in the US have uncovered the workings of a metabolic pathway or “gauge” that lets cancer cells detect when they have enough nutrients around them to grow.

The researchers hope that drugs designed to turn down the gauge may eventually aid in treating many forms of cancer.

“The cancer cell has an unlimited appetite for nutrients,” said Xiaoyong Yang, Associate Professor at Yale Cancer Center and senior author of the study.

Cancer, cells, metabolism, research, treatment, science
Cancer cells in culture from human connective tissue, illuminated by darkfield amplified contrast, at a magnification of 500x. These cells can be compared to normal cells. Wikimedia Commons

“But in many parts of the body, especially for solid tumours, nutrients and oxygen are often limited, so the cell has to make a decision to grow or survive. We have shown how the cell adapts to its microenvironment, detecting nutrient availability to make this decision,” Yang said.

Yang and his colleagues studied the role of a process called O-GlcNAc protein modification in cancer metabolism.

O-GlcNAc modification alters the function of proteins by attaching certain kinds of sugar molecules and is thought to generally act as a nutrient sensor for the cell.

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“We were interested in this modification because it is a common feature across many types of cancer,” Yang noted.

The team began by examining a wide range of human cancer tissue samples for signs of O-GlcNAc modification, including levels of expression for the OGT and OGA enzymes.

They found that both OGT and OGA are expressed at higher levels in many cancers than in normal tissues.

Their findings were published in the journal Oncogene. (IANS)

Next Story

The Dangers of Following Fad Diets: Recognizing the Top 3 Signs

Here are the side effects of following a fad diet

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Fad Diets
In short, a fad diet is one that is “here today and gone tomorrow.”. Lifetime Stock

Almost everyone has tried a diet of some sort in their lifetime, typically with the goal of shedding some extra pounds. Today, there are so many diet plans and regimens out there that if you did a basic Google search, your mind would be overloaded with a plethora of information, leaving you to wreck your brain figuring out which one is best and which one you should try. From diet pills to flat tummy teas, are these dieting plans even effective and sustainable? The more important question you need to be asking yourself is, “are these dieting fads even safe?”

According to nutrition experts, the biggest area where diets tend to fail is its sustainability. There are diets out there that will definitely get the weight off of you but they’re not sustainable, meaning that as soon as you deviate from the diet, all the weight you initially lost, will quickly find its way back to you. Sure, you might be able to go without carbs or try a diet that’s high in fiber, but your body can only properly function for so long without certain nutrients. So these fad diets might help you to shed those unwanted pounds but what is that diet doing to your body in the process? It’s potentially putting your body in danger of certain health risks.

What is a Fad Diet?

In short, a fad diet is one that is “here today and gone tomorrow.” Dieticians refer to fad diets as meal plans that are extremely restrictive with small amounts of foods to consume OR it’s a meal plan with an odd combination of foods; you will typically consume these foods in a short amount of time and lose weight very quickly.

Fad diets
Fad diets include foods that are consumed in a short amount of time and lose weight very quickly. Lifetime Stock

Some fad diet examples include but are not limited to:

  • Atkins Diet
  • Keto Diet
  • South Beach Diet
  • Military Diet

These diets definitely would help people shed the pounds but they weren’t sustainable. Studies have shown that 90% of people who lose weight on these fad diets end up gaining more weight back than they originally lost… why? Because those diets are not sustainable or realistic. The average person with a moderately busy lifestyle would not be able to maintain a lifestyle on these diets, especially when you’re in a rush to lose the weight quickly.
Trying to lose the weight quickly where you start to run into those health risks. Take a look at some of the signs that let you know that a fad diet is negatively affecting your health.

Fad Diets Leave You Feeling Hungry and Fatigued

Being on a fad diet, you’ll be consuming foods low in calories and in carbohydrates. What does that mean? That means that you’re more than likely going to be malnourished. The state of malnutrition can put your body in a metabolic state called “starvation mode.” Starvation mode is what’s going to make you still feel hungry even after you’ve eaten. That’s because that fad diet is so restricted. Not only will you feel hungry still but you’ll also feel fatigued as well.

Instead of resorting to fad diets, there is a diet where you consume a well-balanced diet and lose weight at the same time. The Mediterranean Diet is a diet that has good fats in it that will leave you feeling full all while not consuming very many calories. The recipes are all delicious and also promote heart health. From delicious chicken recipes to a simple recipe for stuffed peppers, the Mediterranean diet is one that’s not only delicious but it’s also sustainable.

Fad Diets Have a Negative Impact on Your Hormones and Metabolism

You know how your body needs fuel to thrive? Well, food is your body’s fuel and in order for your body to properly function, you have to give our body the right kind of fuel (food). It’s almost like putting gas in your car. In order for your car to drive, it requires a certain type of gas. If you put regular unleaded fuel in a car that requires premium, that car is not going to run… that same theory applies to your body.

Fad diets
According to nutrition experts, fad diets are failure as they are not sustainable. Lifetime Stock

As mentioned earlier, fad diets restrict your food intake, which also means that you’re missing out on important nutrients your body needs to function properly. Without those calories from the food you eat, your body won’t be able to use the energy from those foods. So instead of losing weight, your body will indeed do the opposite and store fat because your body has gone into starvation mode.

Can Cause You to Have an Unhealthy Relationship With Food

With these fad diets, you’re so restricted that when you make the mistake of eating something that’s not on your diet, it can cause you to feel guilty for deviating from your diet, which can, in turn, cause you to stress over it… the next thing you know, you find yourself struggling with yet another failed diet, leaving you to stress eat.

According to verywellfit.com, the best way to stop this unealth relationship with food is to find the source of your stress eating. Well, the source is going to be easy to find because it’s your quick-fix diet. If you can kick the diet that’s causing you to stress eat, your health will improve and you won’t have those random food cravings. If you were eating a well-balanced diet, your body wouldn’t even crave those unhealthy foods. 

Be Realistic in Your Approach to Weight Loss

When people make the decision to lose weight, they want the result to happen right away and that’s the reason why a lot of people turn to these fad diets but instead of resorting to fad diets that put your health at risk, try taking a realistic approach to your weight loss? 

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Taking a realistic approach means knowing that it’s not something that’s going to happen overnight. You need to practice patience and embrace a long-term approach to weight loss where you will over time learn sustainable eating habits and make healthier food choices.