Sunday September 22, 2019

“The Cancer Cells Have An Unlimited Appetite For Nutrients,” said Xiaoyong Yang, Professor at Yale

Scientists at Yale Cancer Scientists have uncovered the workings of a metabolic pathway or "gauge" that lets cancer cells detect when they have enough nutrients around them to grow

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Cancer, cells, metabolism, research, treatment, science
the workings of a metabolic pathway or "gauge" that lets cancer cells detect when they have enough nutrients around them to grow.. Pixabay

Scientists at Yale Cancer Scientists at Yale Cancer Center in the US have uncovered the workings of a metabolic pathway or “gauge” that lets cancer cells detect when they have enough nutrients around them to grow.

The researchers hope that drugs designed to turn down the gauge may eventually aid in treating many forms of cancer.

“The cancer cell has an unlimited appetite for nutrients,” said Xiaoyong Yang, Associate Professor at Yale Cancer Center and senior author of the study.

Cancer, cells, metabolism, research, treatment, science
Cancer cells in culture from human connective tissue, illuminated by darkfield amplified contrast, at a magnification of 500x. These cells can be compared to normal cells. Wikimedia Commons

“But in many parts of the body, especially for solid tumours, nutrients and oxygen are often limited, so the cell has to make a decision to grow or survive. We have shown how the cell adapts to its microenvironment, detecting nutrient availability to make this decision,” Yang said.

Yang and his colleagues studied the role of a process called O-GlcNAc protein modification in cancer metabolism.

O-GlcNAc modification alters the function of proteins by attaching certain kinds of sugar molecules and is thought to generally act as a nutrient sensor for the cell.

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“We were interested in this modification because it is a common feature across many types of cancer,” Yang noted.

The team began by examining a wide range of human cancer tissue samples for signs of O-GlcNAc modification, including levels of expression for the OGT and OGA enzymes.

They found that both OGT and OGA are expressed at higher levels in many cancers than in normal tissues.

Their findings were published in the journal Oncogene. (IANS)

Next Story

Here’s What You Can Do To Undo Damage From Prolonged Sitting

These days prolonged sitting on office chairs for long hours, leads to a sedentary lifestyle our bodies were not designed for

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long sitting hours, prolonged sitting, damage, exercise, treatment
Regular jogging was found to be the best type of exercise. Pixabay

After millions of years of physical evolution, modern humans have a body millions died for — quite literally. However, these days prolonged sitting on office chairs for long hours, leads to a sedentary lifestyle our bodies were not designed for.

IANSlife asks a fitness trainer why sitting in the office for too long is dangerous for your body and how one can undo this damage.

“There are three parts to achieve good health — mental wellness, balanced diet and physical movement. Most of us often struggle with the last — physical movement,” says Shivoham, a fitness trainer and brand ambassador at Avvatar Whey Protein.

“Millennials and Gen-Z are accumulating calories, suffering from weak bones, cardiovascular problems and diabetes more than ever before due to long sitting hours.”

For office-goers, Shivoham recommends a minimum of 20 minutes of daily exercise.

“It doesn’t have to be an elaborate work-out with fancy equipment. One just needs to find out what works best for them.”

long sitting hours, damage, exercise, treatment, prolonged sitting
For office-goers, Shivoham recommends a minimum of 20 minutes of daily exercise. Pixabay

Shivoham’s top tips:

*If you go to work via public transport, try to include a walk to your stop.

*Simple tricks like multiple trips to a water cooler to quench thirst can help you increase your steps and thereby exercising your body.

*Regular stretching and flexing can help one keep their joints and muscles in a healthy condition.

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*Ditch chairs sometimes and sit on a swiss ball as it helps in building a strong core.

*Use a standing bench once in a while to keep up the leg movement.

*Try and sit in an Asian squat position to keep your joints in motion.

The fitness guru urges people to be watchful of their posture while sitting in an office chair. Sitting upright and avoiding a sluggish position is what he advises people who have to sit in the office all day. (IANS)