Sunday, October 25, 2020
Home Life Style Health & Fitness "The Cancer Cells Have An Unlimited Appetite For Nutrients," said Xiaoyong Yang,...

“The Cancer Cells Have An Unlimited Appetite For Nutrients,” said Xiaoyong Yang, Professor at Yale

Scientists at Yale Cancer Scientists have uncovered the workings of a metabolic pathway or "gauge" that lets cancer cells detect when they have enough nutrients around them to grow

Scientists at Yale Cancer Scientists at Yale Cancer Center in the US have uncovered the workings of a metabolic pathway or “gauge” that lets cancer cells detect when they have enough nutrients around them to grow.

The researchers hope that drugs designed to turn down the gauge may eventually aid in treating many forms of cancer.

“The cancer cell has an unlimited appetite for nutrients,” said Xiaoyong Yang, Associate Professor at Yale Cancer Center and senior author of the study.

Cancer, cells, metabolism, research, treatment, science
Cancer cells in culture from human connective tissue, illuminated by darkfield amplified contrast, at a magnification of 500x. These cells can be compared to normal cells. Wikimedia Commons

“But in many parts of the body, especially for solid tumours, nutrients and oxygen are often limited, so the cell has to make a decision to grow or survive. We have shown how the cell adapts to its microenvironment, detecting nutrient availability to make this decision,” Yang said.

Yang and his colleagues studied the role of a process called O-GlcNAc protein modification in cancer metabolism.

O-GlcNAc modification alters the function of proteins by attaching certain kinds of sugar molecules and is thought to generally act as a nutrient sensor for the cell.

ALSO READ: Salmonella Bacteria Found In MDH ‘Sambhar Masala’ In US

“We were interested in this modification because it is a common feature across many types of cancer,” Yang noted.

The team began by examining a wide range of human cancer tissue samples for signs of O-GlcNAc modification, including levels of expression for the OGT and OGA enzymes.

They found that both OGT and OGA are expressed at higher levels in many cancers than in normal tissues.

Their findings were published in the journal Oncogene. (IANS)



Most Popular

Stars and Planets Grow Up Together, says Study

In a unique study, astronomers have found compelling evidence that the planets begin forming while stars are still infants and they grow up together...

Diana Penty Talks About Digitalizing Fashion Shows

In a day and age where most things are digital and everything has moved online, one would imagine the same to be the case...

New AI Predicts Risks of Developing Acute Kidney Injury

A new artificial-intelligence-based tool can help clinicians predict which hospitalized patients face a high risk of developing acute kidney injury (AKI), say, researchers, including...

Artificial Limbs to Differently-Abled by Charitable Body

Narayan Seva Sansthan, which runs charitable hospitals in the country for the differently-abled, particularly polio-affected and those affected by birth, has launched a campaign...

Need for Continuing the Polio Immunization During Pandemic

As World Polio Day is observed around the globe amid the COVID-19 pandemic on Saturday, experts underlined the need for continuing the polio immunization...

Patients with NCD More Vulnerable to COVID in India

Researchers have revealed that the COVID-19 pandemic came as a double blow for people with non-communicable diseases (NCDs) such as diabetes, cancer, respiratory problems,...

How to Check if Something is an Online Scam

While there’s no failsafe way to recognize a scam, it never hurts to be vigilant. You can protect yourself when you know what to...

Washing Hands Thoroughly is Far off the Basics

Medical authorities have made themselves clear: washing our hands thoroughly and frequently with soap, or using a hand sanitizer in absence of soap and...

Recent Comments