Never miss a story

Get subscribed to our newsletter


×
The research discovered that specific cancer drugs inhibit a cell signalling process controlling the death-rate of the harmful neutrophils. Pixabay

Certain class of cancer drugs could be used in the future to treat chronic obstructive pulmonary disease (COPD), say researchers, adding that the drugs could be developed to stop the progression of the disease and promote healing within the lungs.

COPD makes breathing progressively more difficult for millions of people around the world, and the study, published in the journal eLIFE has shown the potential for clinically available cancer treatments to treat it.


“COPD is usually treated with steroids and airway muscle relaxants which ease symptoms, but there is currently no effective treatment clinically available to counteract the damage it does to the lungs,” said study researcher Lynne Prince from the University of Sheffield in UK.

“Our research now shows that inhibitors of these cell signalling processes, or ErbB kinases, could have therapeutic potential in neutrophilic inflammatory disease,” Prince added. According to the researchers, the hope of these drugs is that they can clear the damaging cells from the lungs of people living with COPD, preventing any further damage and therefore the progression of the disease for the first time.

They have been investigating the effect of drugs used to treat a variety of cancers on this inflammatory response; the main driver of lung damage in people living with COPD.

People living with COPD experience a wide range of symptoms that have an increasing impact on their quality of life, including breathlessness, coughing and frequent chest infections. The damage to the lungs is driven by inflammation caused by immune cells called neutrophils.

For the results, the research team screened a library of cancer drugs and identified a number of compounds which accelerate the death of the neutrophil cells and promote healing in the lungs.

The research discovered that specific cancer drugs inhibit a cell signalling process controlling the death-rate of the harmful neutrophils. The team also discovered that editing the genes that encode the cell signalling in the first place, further decreased inflammation.


Certain class of cancer drugs could be used in the future to treat chronic obstructive pulmonary disease (COPD), say researchers, adding that the drugs could be developed to stop the progression of the disease and promote healing within the lungs. Pixabay

“As neutrophilic inflammation is also central to the progression of other chronic inflammatory diseases such as rheumatoid arthritis, the research has the potential to impact not only people living with COPD,” said study researcher Stephen Renshaw from the University of Sheffield in UK.

ALSO READ: 80% Medical Students Feel Low Sense of Personal Achievement, Says New Study

“Our next step is to find a way to test these drugs in people with COPD to understand how the ErbB kinase signalling process has an effect on lung inflammation and to address any potential side effects,” Renshaw added. (IANS)


Popular

wikimedia commons

Children playing ringa ringa roses in an open backyard in England

Great historic events that have shaped the world and changed the outlines of countries are often not recorded in memory, or so we think. Wars made sure to destroy evidence and heritage, and the ones who survived told the tale of what really happened. Folklore, albeit through oral tradition kept alive many such stories, hidden in verse, limericks, and rhymes.

Ringa-ringa-roses, a common playtime rhyme among children across the world, is an example of folklore that has survived for many centuries. It tells the story of the The Great Plague of London which ravaged the city between 1665-1666.

Keep Reading Show less
wikimedia commons

Certain tribes have remained matrilineal, where the decision-making power rests with the eldest female of the family.

In modern times, many social movements aim to bring reform to the society we live in, on the basis of certain existing patterns. Patriarchy is something that many aim to cleanse our cultures of, to usher in the era of social and gender equality. Despite all these so-called movements, in southern India, certain societies that patronise matriarchy have existed since before India's independence. The Nairs and Ezhavas of Kerala, and Bunts and Billavas of Karnataka are matrilineal societies that continue to thrive in a patriarchal country.

Kerala remains separate from the rest of India in many ways. Be it literacy policy, form of government, or cultural practices, this state does not always conform to the ideal that India is known for. Even so with their social structure. Certain tribes have remained matrilineal, where the decision-making power rests with the eldest female of the family.

Keep Reading Show less
Photo by Medhat Dawoud on Unsplash

It is the world's top tech company in turnover (totaling $274.5 billion in 2020) and its most valuable corporation.

Apple inc. Is an American multinational tech firm specialized in consumer electronics, computer programs, and internet services founded by Steve Jobs, Steve Wozniak, and Ronald Wayne in 1976 to manufacture Wozniak's Apple iComputer. It is the world's top tech company in turnover (totaling $274.5 billion in 2020) and its most valuable corporation. Apple is the fourth-largest PC seller by unit sales and the fourth-largest smartphone manufacturer in the world.

Apple has revealed a slew of new products at a special launch event that has been long-awaited. On the day of the live event, Apple announced the iPad mini, Apple Watch Series 7, iPhone 13 mini, and iPhone 13, as well as the iPhone 13 Pro and iPhone 13 Pro Max.

Keep reading... Show less