Friday July 19, 2019

Good News for Cancer Patients, Treatments to be Less Invasive

Many people have some combination of chemo, radiation and surgery

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Cancer, Patients, Invasive
The treatments kill healthy cells as well as cancerous ones, and the side effects are legendary. Pixabay

There’s good news for cancer patients: Treatments are becoming less invasive and taking less time.

Traditional treatments often include chemotherapy or radiation to kill cancer cells and shrink tumors. The treatments kill healthy cells as well as cancerous ones, and the side effects are legendary.

Surgery can be an option, too. Sometimes it’s all that’s needed, but many people have some combination of chemo, radiation and surgery. These treatments can span months, and patients have months more of recovery time.

Cancer treatment is now moving toward precision medicine that targets just the cancer.

 Cancer, Patients, Invasive
There’s good news for cancer patients: Treatments are becoming less invasive and taking less time. Pixabay

For example, doctors are using focused radiation, after a lumpectomy, for women who have early stage breast cancer. With this procedure, radiation beams pinpoint the tumor from hundreds of different angles for a short period of time. Each beam itself is weak, but together, when they hit the tumor, the result is a higher dose of radiation.

Just five days

Dr. Julia White at the Ohio State University Comprehensive Cancer Center found focused radiation has the same positive results as full breast radiation. Plus, the partial radiation takes only five days.

White said, “The short five-day treatment is just as good as the whole breast irradiation [that lasts] for four to six weeks.”

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Other treatments use the body’s own immune system. Dr. William Nelson at Johns Hopkins Medicine told VOA it’s clear that the immune system sees cancer cells as abnormal, “and if we unleash the immune system, it can attack and destroy the cancer cells.”

The American Cancer Society says immunotherapy has become an important part of treating some cancers, and that newer types of immune treatments, currently being studied, will affect how we treat cancer in the future.

Still another new treatment, genomic testing, involves testing the cancer cells to determine their genetic makeup.

Most cancers start because of genetic mutations, and each patient’s cancer is unique, just like his or her DNA. If doctors know the particular DNA, they can prescribe medicine that targets the mutated cells. Healthy cells are left alone.

 Cancer, Patients, Invasive
Traditional treatments often include chemotherapy or radiation to kill cancer cells and shrink tumors. Pixabay

Dr. Marcia Brose at the Abramson Cancer Center at the University of Pennsylvania specializes in this type of treatment. In a Skype interview with VOA, she said genomic testing and precision medicine targets cancer cells “at the very core of what made them a cancer to begin with, and that’s what precision medicine is really about.”

Few side effects

Brose said few patients have any side effects. If they do, she lowers the dose of the medication. It eliminates the side effect, and the treatment is still effective.

Because genomic testing is costly, Brose said, the biggest impact right now is for patients whose cancer keeps returning or spreads to other parts of the body. She doesn’t see it yet as a first-line treatment. But the results are outstanding.

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Brose recalled treating a woman with a rare type of cancer called sarcoma. When they met, the patient was in a wheelchair and on oxygen. Brose said that three years after treatment, the woman is hiking with her kids.

Brose said that patients whose cancers aren’t responding to treatment should ask their doctors about genomic testing. It isn’t for everyone, but Brose and other cancer specialists think targeted therapy, immunotherapy or genomic testing and precision medicine are the future of cancer treatment. And one day, it will be the standard treatment worldwide. (VOA)

Next Story

Researchers Find Way to Make Cancer Cells Self-destruct

It also shows that ATF4 turns on the genes MYC needs for growth and also controls the rate at which cells make specific proteins called 4E-BP

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Cancer, Patients, Invasive
Traditional treatments often include chemotherapy or radiation to kill cancer cells and shrink tumors. Pixabay

In a new hope for cancer patients, researchers have found a way to cause some cancer cells to self-destruct.

The research team has identified a new pathway that works as a partner to a gene called MYC which controls normal cell growth, but when it is mutated or amplified in cancer, it sets off a chain reaction that helps tumours grow uncontrollably.

The pathway involves a protein called ATF4, and when it’s blocked, it can cause cancer cells to produce too much protein and die.

Published in the journal Nature Cell Biology, the study done on mice points the way towards a new therapeutic approach as inhibitors that can block synthesis of ATF4 already exist.

Cancer
Cancer Ribbon. Pixabay

“What we’ve learned is that we need to go further downstream to block tumour growth in a way that cancer cells can’t easily escape, and our study identifies the target to do just that,” said Constantinos Koumenis, Professor at the University of California.

According to researchers, this finding shows the alternative approach is to target ATF4 itself, since it’s the point where both signal pathways converge, meaning there’s less redundancy built in to allow cancer to survive.

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It also shows that ATF4 turns on the genes MYC needs for growth and also controls the rate at which cells make specific proteins called 4E-BP.

This study also found that when tumours in humans are driven by MYC, ATF4 and its protein partner 4E-BP are also overly expressed, which is further evidence that these findings may point to an approach that could work for humans. (IANS)