Wednesday March 20, 2019

Cannabidiol Proven Effective in Eliminating Depression

The team found that cannabidiol induced acute and sustained antidepressant-like effects in mice submitted to the forced swim test

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Depression
Cannabidiol effective against depression: Study. Pixabay

A single dose of cannabidiol — a non-intoxicating compound of marijuana — was found highly effective in eliminating the symptoms of depression in rats, finds a study.

The findings showed that as compared to the commercial anti-depressants that typically take two to four weeks to have a significant effect, cannabidiol’s first results appear in 24 hours after a single dose.

Moreover, the beneficial effects were fast acting and sustained, persisting for seven days.

It could be because cannabidiol activates mechanisms which repair neuronal circuitry in patients’ prefrontal cortex and hippocampus, the researchers said.

“In light of the study, we believe cannabidiol rapidly triggers neuroplastic mechanisms that help repair the neuronal circuitry that gets damaged in depression,” said lead author Samia Regiane Lourenco Joca, Professor at the University of Sao Paulo in Brazil.

Depression
Moreover, the beneficial effects were fast acting and sustained, persisting for seven days. Flickr

For the study, published in the journal Molecular Neurobiology, the team performed tests using rat and mouse lines selected by cross-breeding to develop symptoms of depression. The tests and behavioural analysis involved a total of 367 animals.

Before the test, some of the animals were given an injection of cannabidiol with doses of 7, 10 and 30 mg/kg in saline solution, and the rest, which were the control group, received only saline.

After 30 minutes, the animals were placed for five minutes in cylinders with a height of 25 cm and a diameter of 17 cm, containing 10 cm of water for mice and 30 cm of water for rats.

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The team found that cannabidiol induced acute and sustained antidepressant-like effects in mice submitted to the forced swim test.

According to Joca, if studies in humans also find cannabidiol to be beneficial in treating depression, given that cannabidiol is already used in humans to treat other diseases or disorders, “they could result in an important advance in the treatment of depression, potentially helping patients who suffer for weeks, often with a risk of suicide, until the treatment starts working.” (IANS)

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Increased Usage of Digital Media Can Lead to Depression in Young Adults

Moreover, research shows that young people are not sleeping as much as they did in previous generations

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carbon, digital
Multiple apps are displayed on an iPhone in New York.. VOA

Increased use of digital media may be partly responsible for the growth in the percentage of young adults experiencing certain types of mental health disorders in the US over the past decade, suggests new research.

“More US adolescents and young adults in the late 2010s, versus the mid-2000s, experienced serious psychological distress, major depression or suicidal thoughts, and more attempted suicide,” said lead study author Jean Twenge, Professor of Psychology at San Diego State University in the US.

“These trends are weak or non-existent among adults 26 years and over, suggesting a generational shift in mood disorders instead of an overall increase across all ages,” Twenge added.

For the study, the researchers analysed data from the National Survey on Drug Use and Health, a nationally representative survey that has tracked drug and alcohol use, mental health and other health-related issues in individuals aged 12 and over in the US since 1971.

They looked at survey responses from more than 200,000 adolescents aged 12 to 17 from 2005 to 2017, and almost 400,000 adults aged 18 and over from 2008 to 2017.

Social Media, digital, Encryption, drink, whatsapp, depression
Study Links Social Media Addicts, Substance Abusers. (VOA)

The rate of individuals reporting symptoms consistent with major depression in the last 12 months increased 52 per cent in adolescents from 2005 to 2017 – from 8.7 per cent to 13.2 per cent — and 63 per cent in young adults aged 18 to 25 from 2009 to 2017 – from 8.1 per cent to 13.2 per cent, showed the findings published in the Journal of Abnormal Psychology.

“Cultural trends in the last 10 years may have had a larger effect on mood disorders and suicide-related outcomes among younger generations compared with older generations,” said Twenge.

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She believes this trend may be partially due to increased use of electronic communication and digital media, which may have changed modes of social interaction enough to affect mood disorders.

Moreover, research shows that young people are not sleeping as much as they did in previous generations, she noted. (IANS)