Friday November 16, 2018

Cannabidiol Proven Effective in Eliminating Depression

The team found that cannabidiol induced acute and sustained antidepressant-like effects in mice submitted to the forced swim test

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Cannabidiol effective against depression: Study. Pixabay
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A single dose of cannabidiol — a non-intoxicating compound of marijuana — was found highly effective in eliminating the symptoms of depression in rats, finds a study.

The findings showed that as compared to the commercial anti-depressants that typically take two to four weeks to have a significant effect, cannabidiol’s first results appear in 24 hours after a single dose.

Moreover, the beneficial effects were fast acting and sustained, persisting for seven days.

It could be because cannabidiol activates mechanisms which repair neuronal circuitry in patients’ prefrontal cortex and hippocampus, the researchers said.

“In light of the study, we believe cannabidiol rapidly triggers neuroplastic mechanisms that help repair the neuronal circuitry that gets damaged in depression,” said lead author Samia Regiane Lourenco Joca, Professor at the University of Sao Paulo in Brazil.

Depression
Moreover, the beneficial effects were fast acting and sustained, persisting for seven days. Flickr

For the study, published in the journal Molecular Neurobiology, the team performed tests using rat and mouse lines selected by cross-breeding to develop symptoms of depression. The tests and behavioural analysis involved a total of 367 animals.

Before the test, some of the animals were given an injection of cannabidiol with doses of 7, 10 and 30 mg/kg in saline solution, and the rest, which were the control group, received only saline.

After 30 minutes, the animals were placed for five minutes in cylinders with a height of 25 cm and a diameter of 17 cm, containing 10 cm of water for mice and 30 cm of water for rats.

Also Read About Meal Timings Helping in Weight Loss-Changing Breakfast and Dinner Timings Might Help you in Loosing Weight

The team found that cannabidiol induced acute and sustained antidepressant-like effects in mice submitted to the forced swim test.

According to Joca, if studies in humans also find cannabidiol to be beneficial in treating depression, given that cannabidiol is already used in humans to treat other diseases or disorders, “they could result in an important advance in the treatment of depression, potentially helping patients who suffer for weeks, often with a risk of suicide, until the treatment starts working.” (IANS)

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Loneliness And Depression Can Be Linked to Social Media: Study

It is unclear if the depressing effects of social media will cross generational lines to older or younger people

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This photo taken March 22, 2018, shows apps for WhatsApp, Facebook, Instagram and other social networks on a smartphone. VOA

University of Pennsylvania researchers say that for the first time they have linked social media use to increases in depression and loneliness.

The idea that social media is anything but social when it comes to mental health has been talked about for years, but not many studies have managed to actually link the two.

To do that, Penn researchers, led by psychologist Melissa Hunt, designed a study that focused on Facebook, Snapchat and Instagram.

The results were published in the November issue of the Journal of Social and Clinical Psychology.

Social media. Offensive Speech
An iPhone with Twitter, Facebook and other apps, May 21, 2013. U.S. internet companies are taking a harder look at their policies that have promoted free expression around the world.. VOA

How study worked

The study was conducted with 143 participants, who before they began, completed a mood survey and sent along photos of their battery screens, showing how often they were using their phones to access social media.

“We set out to do a much more comprehensive, rigorous study that was also more ecologically valid,” Hunt said. That term, ecologically valid, means that the research attempts to mimic real life.

The study divided the participants into two groups: The first group was allowed to maintain their normal social media habits. The other, the control group, was restricted to 10 minutes per day on each of the three platforms: Facebook, Snapchat and Instagram.

The restrictions were put in place for three weeks and then the participants returned and were tested for outcomes such as fear of missing out (FOMO), anxiety, depression and loneliness.

Social Media
Chiara Valenzano, right, photographs her food as she has lunch with her friend Giulia Terranova at the ‘This is not a Sushi bar’ restaurant, in Milan, Italy, Oct. 16, 2018. At the restaurant, payment can be made according to the number of Instagram followers one has. VOA

Results of study

The results showed a very clear link between social media use and increased levels of depression and loneliness.

“Using less social media than you normally would leads to significant decreases in both depression and loneliness,” Hunt said. “These effects are particularly pronounced for folks who were more depressed when they came into the study.”

She calls her findings the “grand irony” of social media.

What is it about social media that’s just so depressing?

Hunt says that it’s two major things. The first is that social media invites what Hunt calls “downward social comparison.” When you’re online, it can sometimes seem that “everyone else is cooler and having more fun and included in more things and you’re left out,” she said. And that’s just generally demoralizing.

Social Media
The study was conducted with 143 participants, who before they began, completed a mood survey Pixabay

The second factor is a bit more nuanced.

“Time is a zero-sum game,” Hunt told VOA. “Every minute you spend online is a minute you are not doing your work or not meeting a friend for dinner or having a deep conversation with your roommate.”

And these real life activities are the ones that can bolster self-esteem and self worth, Hunt said.

What to learn

So what’s the takeaway?

social media
A girl uses her mobile phone in Jakarta, Indonesia, July 5, 2017. A researcher in Britain says her findings suggest young girls who are more active on social media have lower levels of well-being in their teens. VOA

People are on their devices, and that’s not going to change, she said. But as in life, a bit of moderation goes a long way.

“In general, I would say, put your phone down and be with the people in your life,” she added.

Also Read: Childhood Violence May Spur Puberty, Depression: Study

Hunt pointed out a few caveats to the study. First, it was done exclusively with 18- to 22-year-olds, and it is unclear if the depressing effects of social media will cross generational lines to older or younger people, Hunt said. But she expects her results should generalize at least for people through the age of 30.

Hunt says she is now beginning a study to gauge the emotional impact of dating apps. (VOA)