Saturday November 16, 2019

Cepheid to Establish Manufacturing Unit for TB Diagnostics in India

Rifampicin is a drug commonly used in treating TB bacteria in first line of treatment

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The GeneXpert Edge is developed specifically for near-patient testing, to help support a one visit test-and-treat approach.
The GeneXpert Edge is developed specifically for near-patient testing, to help support a one visit test-and-treat approach. (IANS)

Expanding its footprint in India, US-based molecular diagnostics company Cepheid Inc on Thursday announced its plans to establish a manufacturing unit in the country to improve Tuberculosis (TB) diagnostics.

Cepheid’s GeneXpert MTB/RIF test is a closed-cartridge-based system that is easy to operate by minimally trained staff and gives results in approximately two hours, speeding the conventional backlog that used to exist in traditional diagnostic methods.

The new manufacturing unit would produce MTB/RIF test cartridges, contribute to the government’s “Make in India” initiative and thus bringing the company’s global expertise in TB diagnostics to India, the company said in a statement.

As part of the plan, Cepheid also unveiled its latest portable, easy-to-use TB-testing system — the GeneXpert Edge — which is expected to be available in India later this year, the company said.

The GeneXpert Edge is developed specifically for near-patient testing, to help support a one visit test-and-treat approach.

“Cepheid recognises the need for technological advancement and is committed to contributing significantly to India’s goal of TB eradication,” said Peter Farrell, Executive Vice President, Worldwide Commercial Operations, Cepheid.

Cepheid's Xpert MTB/RIF test has the potential to detect Mycobacterium tuberculosis(MTB)
Cepheid’s Xpert MTB/RIF test has the potential to detect Mycobacterium tuberculosis(MTB).

“We are hopeful that GeneXpert Edge will help eliminate delays in TB diagnostics by providing definitive results within hours and facilitating fast and easy last-mile delivery even in the remote villages of India,” he added.

India has nearly one-fourth of the global TB patients and an estimated 4.8 lakh lives are lost every year due to delayed diagnosis and inadequate treatment and there are above 2.5 million new cases of TB every year. The country aims to eradicate TB by 2025.

Approved by the World Health Organisation (WHO) in 2010, more than 1,200 Cepheid’s GeneXpert Systems have been installed in the last two years at various Revised National Tuberculosis Control Programme (RNTCP) sites in the country and more than 2.5 million cartridges were supplied last year at various centres of Central TB Division (CTD).

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Cepheid’s Xpert MTB/RIF test has the potential to detect Mycobacterium tuberculosis(MTB) and rifampicin-resistance mutations, which are markers for MDR-TB strains in under two hours.

Rifampicin is a drug commonly used in treating TB bacteria in first line of treatment.

Xpert MTB/RIF tests also have excellent negative predictive value, which allows clinicians to manage TB-negative patients more effectively to prevent unnecessary and costly respiratory isolations. (IANS)

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Sambhar Lake Becomes Death Bed for Large Number of Birds

The excessive salt in the water led to the poisoning, causing hypernectremia, which is water deprivation due to sodium intoxication

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Sambhar Lake
After witnessing drought for many years, this year the Sambhar Lake, however, brimmed with water due to heavy rains. The inflow made the water toxic due to the change in its alkalinity. Pixabay

A deadly game of survival is on in the Sambhar lake of Rajasthan for decades — salt versus birds. The result came a few days back: thousands of birds were seen floating dead in the lake and their carcasses scattered on the edge of the 12 km catchment area.

The dead birds seen floating in this largest inland salt lake in the country, include plovers, common coot, black winged stilt, northern shovelers, ruddy shelduck, and pied avocet among many other migratory birds.

Harsh Vardhan, a renowned environmentalist, told IANS that no forest department official has ever been appointed to look after the lake. The lake comes under the Hindustan Salt Limited, a public limited enterprise formed in the post independence era to manufacture salt. Its job is to manufacture salt. So who should look after the lake; this has never been decided, he said.

The lake has not been handed to the forest department, and the area, where birds come, is no one’s land. Sambhar lake may be a part of the Hindustan Salt Ltd, but the company has nothing to do with the birds, he says.

The chief wildlife warden Arindam Tomar has maintained silence over the issue.

Even, Principal secretary, forest and environment Shreya Guha has washed her hands off the issue. All that she did was to a give statement that the Jaipur and Nagaur District Collectors have been asked to remove the bodies. She added that 4,800 birds have been dead till date, which is disputed by experts like Harsh Vardhan, who say that counting is not easy in the vast area.

Chief minister Ashok Gehlot on Thursday held a meeting on the issue.

Sambhar Lake
A deadly game of survival is on in the Sambhar Lake of Rajasthan for decades — salt versus birds. Pixabay

Meanwhile, Harsh Vardhan questioned the presence of several private salt miners and entrepreneurs, who have set shops in and around the lake. “They dig tube wells which suck water from the land making it parched. The remaining water gets evaporated leaving crystal of salts which are packed and sold in gunny bags,” he said.

Lack of water and drought has haunted Sambhar lake for years. State government has been spending huge money to woo tourists through activities like mobiking, balloning, race, Bollywood shoots, etc. A resort on the rim of the lake showcases salt manufacturing for the tourists. Crores of Rupees have been spent on the upkeep of the narrow gauge train and watch stations, but birds and conversation issues were always overlooked.

As Sambhar lake went dry, concentration of salt deposits came up within it. The water from surrounding rivers, meant to flow into the lake, was diverted by the miners.

After witnessing drought for many years, this year the lake, however, brimmed with water due to heavy rains. The inflow made the water toxic due to the change in its alkalinity.

The excessive salt in the water led to the poisoning, causing hypernectremia, which is water deprivation due to sodium intoxication, Vardhan said.

It seems birds which came in high numbers due to high water quantity this season died due to hypernectermia after consuming their feed which is the planktons, the microrganisms found in water.

Sambhar Lake
The dead birds seen floating in this largest inland salt lake i.e Sambhar Lake in the country, include plovers, common coot, black winged stilt, northern shovelers, ruddy shelduck, and pied avocet among many other migratory birds. Wikimedia Commons

The only step that has ever been taken by any government in the state was in 1981 when it was decided to designate the site as wetland and was renamed as the Ramsar site.

According to an estimate, around 60,000 birds visited the lake in a year which has come down to less than 20,000.

Vardhan says that if the lake remains with the Hindustan Salt Limited, which has been a loss making unit since years or if it is handed over to the private operators, who do excessive mining of water, then the lake and the birds are sure to die.

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Experts like him want the lake to be handed over to the forest department which can develop it as a wetland. (IANS)