Tuesday December 11, 2018

Cepheid to Establish Manufacturing Unit for TB Diagnostics in India

Rifampicin is a drug commonly used in treating TB bacteria in first line of treatment

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The GeneXpert Edge is developed specifically for near-patient testing, to help support a one visit test-and-treat approach.
The GeneXpert Edge is developed specifically for near-patient testing, to help support a one visit test-and-treat approach. (IANS)
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Expanding its footprint in India, US-based molecular diagnostics company Cepheid Inc on Thursday announced its plans to establish a manufacturing unit in the country to improve Tuberculosis (TB) diagnostics.

Cepheid’s GeneXpert MTB/RIF test is a closed-cartridge-based system that is easy to operate by minimally trained staff and gives results in approximately two hours, speeding the conventional backlog that used to exist in traditional diagnostic methods.

The new manufacturing unit would produce MTB/RIF test cartridges, contribute to the government’s “Make in India” initiative and thus bringing the company’s global expertise in TB diagnostics to India, the company said in a statement.

As part of the plan, Cepheid also unveiled its latest portable, easy-to-use TB-testing system — the GeneXpert Edge — which is expected to be available in India later this year, the company said.

The GeneXpert Edge is developed specifically for near-patient testing, to help support a one visit test-and-treat approach.

“Cepheid recognises the need for technological advancement and is committed to contributing significantly to India’s goal of TB eradication,” said Peter Farrell, Executive Vice President, Worldwide Commercial Operations, Cepheid.

Cepheid's Xpert MTB/RIF test has the potential to detect Mycobacterium tuberculosis(MTB)
Cepheid’s Xpert MTB/RIF test has the potential to detect Mycobacterium tuberculosis(MTB).

“We are hopeful that GeneXpert Edge will help eliminate delays in TB diagnostics by providing definitive results within hours and facilitating fast and easy last-mile delivery even in the remote villages of India,” he added.

India has nearly one-fourth of the global TB patients and an estimated 4.8 lakh lives are lost every year due to delayed diagnosis and inadequate treatment and there are above 2.5 million new cases of TB every year. The country aims to eradicate TB by 2025.

Approved by the World Health Organisation (WHO) in 2010, more than 1,200 Cepheid’s GeneXpert Systems have been installed in the last two years at various Revised National Tuberculosis Control Programme (RNTCP) sites in the country and more than 2.5 million cartridges were supplied last year at various centres of Central TB Division (CTD).

Also Read: Fruit Bats Identified As Source Of Nipah Virus Outbreak in Kerala

Cepheid’s Xpert MTB/RIF test has the potential to detect Mycobacterium tuberculosis(MTB) and rifampicin-resistance mutations, which are markers for MDR-TB strains in under two hours.

Rifampicin is a drug commonly used in treating TB bacteria in first line of treatment.

Xpert MTB/RIF tests also have excellent negative predictive value, which allows clinicians to manage TB-negative patients more effectively to prevent unnecessary and costly respiratory isolations. (IANS)

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Hindus In Delhi Push For A Temple On The Ruins Of a Mosque

The Supreme Court has delayed hearings into the disputed site but hardliners have vowed to lay a foundation stone next year regardless.

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Supporters of Vishwa Hindu Parishad gather during a rally in New Delhi, Dec. 9, 2018. The group gathered thousands of supporters to demand the construction of a Hindu temple on a site where a mosque was attacked, demolished in 1992. VOA

Tens of thousands of hardline Hindu protesters marched in New Delhi on Sunday, calling for a grand temple to be built on the ruins of a destroyed mosque in a flashpoint Indian city.

Trident-waving devotees clad in saffron filled a huge parade ground in the Indian capital under tight security, where speakers warned Prime Minister Narendra Modi they would not let up until the temple was sanctioned.

Some of Modi’s supporters feel the Hindu nationalist leader has not done enough to raise a shrine at a site in Ayodhya, a city believed by many to be the birthplace of the deity Ram.

The site was home to a medieval mosque for 460 years until Hindu zealots tore it down in 1992, kicking off riots across India that left thousands dead, most of them Muslims.

Its future has been tied up in courts for decades but some hardliners want Modi, who is seeking reelection in 2019, to push parliament to guarantee the temple by law.

World Hindu Congress, Hindu
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“The gathering here is telling you that Hindus won’t sit back until the temple is built, and our wishes are respected,” said Champat Rai, the leader of the Vishva Hindu Parishad (VHP) group that organized the protest.

Demonstrators chanting “Praise be to Ram” packed the Ramlila Maidan, a vast ground capable of holding more than 50,000 people, and filled the surrounding streets.

Some carried maces and tridents — weapons traditionally wielded by Hindu gods — and traveled great distances by train and bus to reach the rally.

“We have come here to protect our religion and Hindu pride. We want a temple for our Lord Ram,” Hitesh Bharadwaj, a teacher from Delhi’s satellite city Noida, told AFP.

The hardline VHP has applied pressure on Modi in recent weeks, staging a huge show of force in Ayodhya itself last month.

Hindu, Mosque
Photo credit: theguardian.com

A close ally of Modi’s Bharatiya Janata Party (BJP), the group is spearheading a push to raise the Ram temple, and is calling for more protests as the premier prepares to go to the polls by May.

The BJP was on the margins until the 1980s when its top leaders, including Modi, backed a growing movement for the construction of the Ram temple.

Its advocates want parliament to introduce a law bypassing legal hurdles blocking the temple before Modi’s term ends.

Also Read: Delhi’s Air Quality Leads To Ban On Trucks And Construction

The Supreme Court has delayed hearings into the disputed site but hardliners have vowed to lay a foundation stone next year regardless.

“We don’t care about the courts. A grand temple will be constructed in 2019,” Sushil Chawdhary, a VHP leader, told AFP. (VOA)