Sunday January 26, 2020

Children with Mild Asthma can Effectively Manage Condition by Using Two Inhalers

Patients in the group that used both inhalers as needed used about one-fourth the steroid dose of the group that inhaled a prescribed daily amount

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Children, Mild, Asthma
The steroid inhaler lowers inflammation and the bronchodilator, also known as a rescue inhaler, relaxes the airway during an asthma attack to quickly make breathing easier, according to the study published. Pixabay

Researchers have found that children with mild asthma can effectively manage the condition by using their two inhalers — one a steroid and the other a bronchodilator — when symptoms occur.

The steroid inhaler lowers inflammation and the bronchodilator, also known as a rescue inhaler, relaxes the airway during an asthma attack to quickly make breathing easier, according to the study published in the Journal of Allergy and Clinical Immunology: In Practice.

“Patients in the group that used both inhalers as needed used about one-fourth the steroid dose of the group that inhaled a prescribed daily amount. We also were pleased to see that the patients and families felt that they had more ownership over their asthma management when practicing as-needed treatment,” said study first author Kaharu Sumino, Associate Professor at the Washington University.

The researchers found that this approach reduced the amount of steroid medication the children took monthly by almost 75 per cent.

Children, Mild, Asthma
Researchers have found that children with mild asthma can effectively manage the condition by using their two inhalers — one a steroid and the other a bronchodilator — when symptoms occur. Pixabay

The study included 206 African American children six to 17 years of age with mild asthma that was adequately controlled with asthma controller steroid medication. The patients were randomly assigned to one of two groups.

Each participant in one group was advised to take a dose from an inhaler containing the steroid beclomethasone as needed when symptoms arose, along with the rescue bronchodilator albuterol.

Each participant in the second group was advised to take a specific inhaled dose of the steroid beclomethasone daily, regardless of symptoms, plus the rescue bronchodilator as needed in response to symptoms.oo

At the end of the one-year study, the researchers found no differences between groups in surveys of how well the patients’ asthma was controlled, as well as no differences in breathing tests that measure lung function.

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However, the group taking daily beclomethasone, an inhaled corticosteroid, used more of the medication per month than those in the symptom-based group.

On average, children in the daily-use group used 1,961 micrograms per month, while the symptom-based group used 526 micrograms per month, cutting the amount of this medication by almost three-fourths. The reduced amount is desirable, according to the investigators, because steroids have side effects that include stunted growth. (IANS)

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Exposure To High Levels of Air Pollution May Lead To Changes in Children’s Brain Structure

Previous studies of traffic-related air pollution suggest that it contributes to neurodegenerative diseases and neurodevelopmental disorders

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Air Pollution
The researchers found that children with higher levels of air pollution exposure at birth had reductions at age 12 in gray matter volume and cortical thickness as compared to children with lower levels of exposure. Pixabay

Exposure to high levels of traffic-related air pollution at age 1 may lead to structural changes in the brain at the age of 12 which can influence the development of various physical and mental processes, warns a study.

The researchers found that children with higher levels of air pollution exposure at birth had reductions at age 12 in gray matter volume and cortical thickness as compared to children with lower levels of exposure. Gray matter includes regions of the brain involved in motor control as well as sensory perception, such as seeing and hearing. Cortical thickness reflects the outer gray matter depth.

The study, published online in the journal PLOS One, found that specific regions in the frontal and parietal lobes and the cerebellum were affected with decreases on the order of three to four per cent. “The results of this study, though exploratory, suggest that where you live and the air you breathe can affect how your brain develops,” said lead author of the study Travis Beckwith, PhD, a research fellow at Cincinnati Children’s Hospital Medical Center in the US.

“While the percentage of loss is far less than what might be seen in a degenerative disease state, this loss may be enough to influence the development of various physical and mental processes,” Beckwith said. For the study, the researchers used magnetic resonance imaging to obtain anatomical brain images from 147 kids.

These children are a subset of the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), which recruited volunteers prior to the age of six months to examine early childhood exposure to traffic-related air pollution and health outcomes.

Pollution
Exposure to high levels of traffic-related air pollution at age 1 may lead to structural changes in the brain at the age of 12 which can influence the development of various physical and mental processes, warns a study. Pixabay

The volunteers in the CCAAPS had either high or low levels of pollution exposure during their first year of life. The researchers estimated exposure using an air sampling network of 27 sites in the Cincinnati area, and 24/7 sampling was conducted simultaneously at four or five sites over different seasons.

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Participating children and their caregivers completed clinic visits at ages 1, 2, 3, 4, 7 and 12. Previous studies of traffic-related air pollution suggest that it contributes to neurodegenerative diseases and neurodevelopmental disorders. (IANS)