Sunday January 26, 2020

Children of Diabetic Mothers May Develop Heart Risks: Study

Kids born of diabetic mothers at heart risk

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Diabetes- heart
Children of mothers with diabetes have increased rates of early onset heart diseases. Pixabay

Children of mothers with diabetes have increased rates of early onset cardiovascular disease or CVD (conditions affecting the heart or blood vessels) from childhood up to the age of 40, the researchers have warned.

The increased rates were more pronounced among children of mothers with a history of CVD or diabetic complications, said the study published in the journal The BMJ.

“our study provides evidence that children of mothers with diabetes, especially those with a history of CVD or with diabetic complications, had increased rates of early onset CVD throughout the early decades of life,” said study researchers from Aarhus University in Denmark.

If this association is shown to be causal, preventing, screening, and treating diabetes in women of childbearing age could be important not only for improving the health of the women but also for reducing long term risks of CVD in their offspring, the researchers added

The number of women diagnosed with diabetes before or during pregnancy has increased globally, and children of these women are more likely to have risk factors for future CVD, such as high blood pressure and high blood sugar levels.

It is unclear, however, whether or to what extent exposure to diabetes in the womb increases the risk of developing CVD in offspring over a lifetime.

Heart disease
Children with diabetic mothers may develop CVD which may increase heart complications. Pixabay

So an international team of researchers set out to evaluate associations between diabetes diagnosed before or during pregnancy and early onset CVD in children during their first four decades of life.

They base their findings on national registry data for over 2.4 million children born without congenital heart disease in Denmark from 1977 to 2016.

Diabetes was categorised as pregestational (before pregnancy) or gestational (during pregnancy) and women with diabetic complications were identified.

Other potentially influential factors, such as mother’s age, education, lifestyle and medical history were also taken into account.

During up to 40 years of follow-up, children of mothers with diabetes had a 29 per cent increased overall rate of early onset CVD compared with children of mothers who did not have diabetes (cumulative risks: 17.8 per cent vs 13.1 per cent ).

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The researchers also found higher rates for specific types of CVD children of mothers with diabetes, particularly heart failure (45 per cent), hypertensive disease (78 per cent), deep vein thrombosis (82 per cent), and pulmonary embolism (91 per cent).

Increased rates were seen in each age group in childhood (before 20 years of age) and early adulthood (from 20 to 40 years of age), regardless of the type of diabetes they were exposed to (pregestational or gestational) and rates were similar for both type 1 and type 2 diabetes, the study said. (IANS)

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Exposure To High Levels of Air Pollution May Lead To Changes in Children’s Brain Structure

Previous studies of traffic-related air pollution suggest that it contributes to neurodegenerative diseases and neurodevelopmental disorders

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Air Pollution
The researchers found that children with higher levels of air pollution exposure at birth had reductions at age 12 in gray matter volume and cortical thickness as compared to children with lower levels of exposure. Pixabay

Exposure to high levels of traffic-related air pollution at age 1 may lead to structural changes in the brain at the age of 12 which can influence the development of various physical and mental processes, warns a study.

The researchers found that children with higher levels of air pollution exposure at birth had reductions at age 12 in gray matter volume and cortical thickness as compared to children with lower levels of exposure. Gray matter includes regions of the brain involved in motor control as well as sensory perception, such as seeing and hearing. Cortical thickness reflects the outer gray matter depth.

The study, published online in the journal PLOS One, found that specific regions in the frontal and parietal lobes and the cerebellum were affected with decreases on the order of three to four per cent. “The results of this study, though exploratory, suggest that where you live and the air you breathe can affect how your brain develops,” said lead author of the study Travis Beckwith, PhD, a research fellow at Cincinnati Children’s Hospital Medical Center in the US.

“While the percentage of loss is far less than what might be seen in a degenerative disease state, this loss may be enough to influence the development of various physical and mental processes,” Beckwith said. For the study, the researchers used magnetic resonance imaging to obtain anatomical brain images from 147 kids.

These children are a subset of the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), which recruited volunteers prior to the age of six months to examine early childhood exposure to traffic-related air pollution and health outcomes.

Pollution
Exposure to high levels of traffic-related air pollution at age 1 may lead to structural changes in the brain at the age of 12 which can influence the development of various physical and mental processes, warns a study. Pixabay

The volunteers in the CCAAPS had either high or low levels of pollution exposure during their first year of life. The researchers estimated exposure using an air sampling network of 27 sites in the Cincinnati area, and 24/7 sampling was conducted simultaneously at four or five sites over different seasons.

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Participating children and their caregivers completed clinic visits at ages 1, 2, 3, 4, 7 and 12. Previous studies of traffic-related air pollution suggest that it contributes to neurodegenerative diseases and neurodevelopmental disorders. (IANS)