Saturday January 18, 2020

Chilli Can Serve As A Valuable Medicine in Case of Lung Cancer

Additional experiments revealed capsaicin suppresses lung cancer metastasis by inhibiting activation of the protein Src. This protein plays a role in the signalling that controls cellular processes like proliferation, differentiation, motility and adhesion.

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In experiments involving three lines of cultured human non-small cell lung cancer cells, researchers observed capsaicin inhibited invasion, the first step of the metastatic process. Pixabay

Besides spicing up your food, chilli, it seems, also has some medicinal value. New research suggests the compound responsible for chilli’s heat could help slow the spread of lung cancer, the leading cause of cancer death for both men and women.

Most cancer-related deaths occur when cancer spreads to distant sites, a process called metastasis.

“Lung cancer and other cancers commonly metastasise to secondary locations like the brain, liver or bone, making them difficult to treat,” said one of the study authors Jamie Friedman from Marshall University in the US.

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They also found mice with metastatic cancer that consumed capsaicin showed smaller areas of metastatic cancer cells in the lung compared with mice not receiving the treatment. Pixabay

“Our study suggests the natural compound capsaicin from chilli peppers could represent a novel therapy to combat metastasis in lung cancer patients,” said Friedman, a doctoral candidate who performed the research in the laboratory of Piyali Dasgupta at Marshall University Joan C. Edwards School of Medicine.

In experiments involving three lines of cultured human non-small cell lung cancer cells, researchers observed capsaicin inhibited invasion, the first step of the metastatic process.

They also found mice with metastatic cancer that consumed capsaicin showed smaller areas of metastatic cancer cells in the lung compared with mice not receiving the treatment.

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Most cancer-related deaths occur when cancer spreads to distant sites, a process called metastasis. Pixabay

The findings were presented during the 2019 Experimental Biology meeting being held from April 6-9 in Orlando, Florida.

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Additional experiments revealed capsaicin suppresses lung cancer metastasis by inhibiting activation of the protein Src. This protein plays a role in the signalling that controls cellular processes like proliferation, differentiation, motility and adhesion.

“We hope one day capsaicin can be used in combination with other chemotherapeutics to treat a variety of lung cancers,” said Friedman. (IANS)

Next Story

Researchers Develop AI Tool To Detect Mental Health Issues

Tracking changes in clinical states is important to detect if there is a change that shows whether the condition has improved or worsened that would warrant the need for changing treatment

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The USC Signal Analysis and Interpretation Lab (SAIL), which has long applied artificial intelligence (AI) and machine learning to identify and classify video, audio and physiological data, partnered with researchers to analyse voice data from patients being treated for serious mental illnesses. Pixabay

Researchers, including one of Indian-origin, have developed an artificial intelligence (AI) tool that can accurately detect changes in clinical states in voice data of patients with bipolar, schizophrenia and depressive disorders as accurately as attending doctors.

“Machine learning allowed us to illuminate the various clinically-meaningful dimensions of language use and vocal patterns of the patients over time and personalised at each individual level,” said Indian-origin researcher and study senior author Shri Narayanan from University of Southern California (USC) in the US.

The USC Signal Analysis and Interpretation Lab (SAIL), which has long applied artificial intelligence and machine learning to identify and classify video, audio and physiological data, partnered with researchers to analyse voice data from patients being treated for serious mental illnesses.

For the results, the researchers used the ‘MyCoachConnect’ interactive voice and mobile tool, created and hosted on the Chorus platform to provide voice diaries related to their mental health states.

SAIL team then collaborated with researchers to apply artificial intelligence to listen to hundreds of voicemails using custom software to detect changes in patients’ clinical states. According to the study, the AI was able to match clinicians’ ratings of their patients.

Tracking changes in clinical states is important to detect if there is a change that shows whether the condition has improved or worsened that would warrant the need for changing treatment, the researchers said.

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Researchers, including one of Indian-origin, have developed an artificial intelligence (AI) tool that can accurately detect changes in clinical states in voice data of patients with bipolar, schizophrenia and depressive disorders as accurately as attending doctors. Pixabay

This project builds on SAIL’s body of work in behavioural machine intelligence to analyse psychotherapy sessions to detect empathy of addiction counselors-in-training in order to improve their chances of better outcomes, in addition to the Lab’s work analysing language for cognitive diagnoses and legal processes.

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“Our approach builds on that fundamental technique to hear what people are saying about using the modern AI. We hope this will help us better understand how our patients are doing and transform mental health care to be more personalised and proactive to what an individual needs,” said study lead author Armen Arevian. (IANS)