Friday August 23, 2019

Chinese Scientists to Start Testing Long-lasting HIV Vaccine on Humans

There are nearly 1.25 million HIV-positive patients in China, where around 80,000 people contract the disease every year, according to the National Health Commission

0
//
sexually transmitted disease
A nurse takes blood from a man for a free HIV test on a bus in Tehran, Dec. 16, 2015. VOA

A group of Chinese scientists will start trialing a long-lasting human immunodeficiency virus (HIV) vaccine on 160 volunteers, the first time that such a vaccine has reached a second-phase human trial, the official newspaper China Daily reported on Friday.

The candidate vaccine, known as DNA-rTV, relies on replication of the virus’ DNA to stimulate “effective immunization” against the virus, said Shao Yiming, an HIV researcher at the Chinese Centre for Disease Control and Prevention.

According to Shao, this vaccine — similar to the one used to prevent smallpox — is the first to undergo a second-phase human trial.

“With significant reduction of virulence, the vaccine will not cause infection in healthy receivers,” Shao was quoted as saying by Efe news.

Moreover, the vaccine being developed does not contain all segments of the virus but some parts of its genetic material, so that the chances of infection are significantly reduced, the report said.

The DNA of the virus will continue replicating after vaccination, thereby stimulating the immune system continuously to produce antibodies, a similar process to the one used by vaccines for other diseases.

HIV
Nearly 40 individual HPV types linked to HIV infection. Pixabay

Most of the HIV vaccines being developed in China and around the world are inactivated vaccines, which do not contain HIV DNA that can replicate, so their effect is not long-lasting.

The first phase of testing, started in 2007, proved the “safety” of the vaccine while the second phase will serve to determine the vaccination procedure to be followed in the future, Shao said.

“Hopefully, the second-phase trial will be completed in the latter half of 2021, and the third-phase clinical trial may start at the end of that year, which will involve thousands of volunteers in a trial to test the effectiveness of the vaccine to protect people against HIV,” he added.

Also Read: Cigarette Butts Significantly Reduce Plant Growth, Find Researchers

The research group has already recruited over 130 volunteers and initial work has begun in two Chinese hospitals, one in Beijing and another in Hangzhou in eastern China.

Chuang Chuang, head of Hangzhou Sunflower, a non-profit promoting lesbian, gay, bisexual, and transgender (LGBT) rights, told China Daily that over 100 volunteers had already registered with the organization after coming to know about the second phase.

There are nearly 1.25 million HIV-positive patients in China, where around 80,000 people contract the disease every year, according to the National Health Commission. (IANS)

Next Story

People Living with HIV Significantly Elevates Risk of Chronic Obstructive Pulmonary Disease (COPD)

They found that people living with HIV are at an increased risk of contracting specific diseases and illnesses

0
HIV, COPD, Disease
For the study, published in the journal Clinical Infectious Diseases, researchers combined data from 20 separate observational studies and examined 55 different illnesses. Pixabay

People living with HIV have a significantly elevated risk of Chronic Obstructive Pulmonary Disease (COPD) and coughs, heart disease, pregnancy mortality and sepsis, anemia and bone fractures, according to a study.

For the study, published in the journal Clinical Infectious Diseases, researchers combined data from 20 separate observational studies and examined 55 different illnesses.

They found that people living with HIV are at an increased risk of contracting specific diseases and illnesses, some of which are more commonly associated with ageing.

“By pooling data from different studies, we have been able to show for the first time that even with the rise in life expectancy amongst people living with HIV, this population now seems to be disproportionately affected by chronic illnesses often attributable to lifestyle issues such as smoking, drug and alcohol use or more commonly associated with an older population,” said study researcher Lee Smith from Anglia Ruskin University in the UK.

HIV, COPD, Disease
People living with HIV have a significantly elevated risk of Chronic Obstructive Pulmonary Disease (COPD) and coughs, heart disease, pregnancy mortality and sepsis, anemia and bone fractures. Pixabay

Although the number of people contracting HIV is declining, approximately 1.8 million people are infected every year and HIV remains one of the world’s major health issues.

In recent years, people with HIV have benefited from improved access to antiretroviral treatment. However, increased life expectancy and a lower immunity has meant higher levels of comorbidity, with people living with HIV also more likely to suffer from other illnesses.

The greater prevalence of age-associated diseases may be explained by the persistent immunodeficiency and inflammation connected with HIV. There are also adverse effects associated with antiretroviral treatment.

Also Read- Doctors can Help Parents and Teens Communicate about Sex

Previous studies have also suggested that people with HIV in developed countries, as a population, often exhibit greater risk factors associated with non-AIDS related illnesses, such as smoking, drug use and alcohol use. (IANS)