Tuesday April 23, 2019

Chinese Researchers Reveal Mechanism of Chronic Stress Promoting Breast Cancer Development

Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours

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Breast Cancer
Nano technology offers hope for better cancer testing. Pixabay

Chinese researchers have revealed the mechanism of how chronic stress promotes breast cancer development, shedding light on future clinical treatment for cancer.

Cancer patients often suffer negative emotions such as anxiety, despair and fear, which are risk factors facilitating tumour growth as well as promoting cancer progression. However, the specific mechanisms of how chronic stress affects cancer development remains unknown yet.

Researchers from the Dalian Medical University in China found that chronic stress might increase epinephrine levels, which enhances lactate dehydrogenase A (LDHA) and promotes breast cancer stem-like cells, Xinhua reported.

Using a drug screen that targeted LDHA, they found that Vitamin C reversed the chronic stress-induced cancer stem-like phenotype.

The study demonstrates the critical importance of psychological factors in promoting stem-like properties in breast cancer cells and provides a promising therapeutic approach for breast cancer, according to Liu Qiang, lead researcher at the varsity.

Representational image.

“The LDHA-lowering agent Vitamin C can be a potential approach for combating stress-associated breast cancer,” Qiang said, in the paper published in the Journal of Clinical Investigation.

His team has been engaged in the dynamic regulation of cancer stem cells research as well as the mechanism of psychosocial behaviour affecting tumour development.

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Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours.

“It is necessary to monitor their chronic stress comprehensively by taking psychological assessments as well as conducting blood tests which include epinephrine levels,” Qiang said. (IANS)

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Research Claims, Regular Exercise Can Boost Life Of Breast Cancer Survivors

"The main cause of mortality in women diagnosed with early-stage breast cancer is heart disease," said Kyuwan Lee, doctoral student at the University of Southern California (USC), noting that prescribed exercise is not considered standard care currently.

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The study found that patients who participated in a 16-week exercise programme had a significantly reduced risk of developing cardiovascular disease over their sedentary counterparts. Pixabay

Exercise can likely reduce the risk of heart disease in women with breast cancer, results of a clinical trial has showed.

Breast cancer patients are exposed to a higher risk of cardiovascular complications during and after cancer treatment from chemotherapy and radiation therapy. These can be exacerbated by obesity and sedentary lifestyles.

The study found that patients who participated in a 16-week exercise programme had a significantly reduced risk of developing cardiovascular disease over their sedentary counterparts.

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In his next phase, he plans to study prevention of cardiovascular dysfunction in cancer patients undergoing cardio-toxic chemotherapy, which uses drugs whose side effects can cause irreversible damage to the heart muscles. Pixabay

“The main cause of mortality in women diagnosed with early-stage breast cancer is heart disease,” said Kyuwan Lee, doctoral student at the University of Southern California (USC), noting that prescribed exercise is not considered standard care currently.

“We hope that this study shows the importance of exercise in reducing the risk of heart disease to emphasise the need to integrate exercise into clinical practice for cancer patients,” he added.

cancer
Breast cancer patients are exposed to a higher risk of cardiovascular complications during and after cancer treatment from chemotherapy and radiation therapy. These can be exacerbated by obesity and sedentary lifestyles. VOA

For the study, published in the journal Oncology, the team conducted a randomised clinical trial that included 100 sedentary, obese women breast cancer stage I-III survivors.

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The women participated in three weekly supervised one-on-one exercise sessions for 16 weeks: 80-minute sessions of resistance and aerobic exercise for two days and 50 minutes of aerobic exercise on the third day. This intervention meets the exercise guidelines set forth by the American Cancer Society for cancer survivors.

The findings are only the beginning for Lee. In his next phase, he plans to study prevention of cardiovascular dysfunction in cancer patients undergoing cardio-toxic chemotherapy, which uses drugs whose side effects can cause irreversible damage to the heart muscles. (IANS)