Monday December 9, 2019

Chinese Researchers Reveal Mechanism of Chronic Stress Promoting Breast Cancer Development

Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours

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Breast Cancer
Nano technology offers hope for better cancer testing. Pixabay

Chinese researchers have revealed the mechanism of how chronic stress promotes breast cancer development, shedding light on future clinical treatment for cancer.

Cancer patients often suffer negative emotions such as anxiety, despair and fear, which are risk factors facilitating tumour growth as well as promoting cancer progression. However, the specific mechanisms of how chronic stress affects cancer development remains unknown yet.

Researchers from the Dalian Medical University in China found that chronic stress might increase epinephrine levels, which enhances lactate dehydrogenase A (LDHA) and promotes breast cancer stem-like cells, Xinhua reported.

Using a drug screen that targeted LDHA, they found that Vitamin C reversed the chronic stress-induced cancer stem-like phenotype.

The study demonstrates the critical importance of psychological factors in promoting stem-like properties in breast cancer cells and provides a promising therapeutic approach for breast cancer, according to Liu Qiang, lead researcher at the varsity.

Representational image.

“The LDHA-lowering agent Vitamin C can be a potential approach for combating stress-associated breast cancer,” Qiang said, in the paper published in the Journal of Clinical Investigation.

His team has been engaged in the dynamic regulation of cancer stem cells research as well as the mechanism of psychosocial behaviour affecting tumour development.

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Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours.

“It is necessary to monitor their chronic stress comprehensively by taking psychological assessments as well as conducting blood tests which include epinephrine levels,” Qiang said. (IANS)

Next Story

Regular Use Of Hair Dye And Straightener May Increase The Risk Of Breast Cancer

An intriguing finding was the association between the use of chemical hair straighteners and breast cancer

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Breast cancer pink ribbon
Breast cancer survival rates are rising as screening and treatment improve. Pixabay

Researchers have found that women who use permanent hair dye and chemical hair straighteners have a higher risk of developing breast cancer than women who don’t use these products.

The study, published in the International Journal of Cancer, suggests that this risk increased with more frequent use of these chemical hair products.

“Researchers have been studying the possible link between hair dye and cancer for a long time, but results have been inconsistent,” said study author Alexandra White from National Institute of Environmental Health Sciences (NIEHS) in US.

“In our study, we see a higher risk associated with hair dye use, and the effect is stronger in African American women, particularly those who are frequent users,” White said.

Using data from 46,709 women in the Sister Study, researchers at NIEHS, found that women who regularly used permanent hair dye in the year prior to enrolling in the study were nine per cent more likely than women who didn’t use hair dye to develop breast cancer.

Among African American women, using permanent dyes every five to eight weeks or more was associated with a 60 per cent increased risk of breast cancer as compared with an eight per cent increased risk for white women.

The research team found little to no increase in breast cancer risk for semi-permanent or temporary dye use.

Permanent hair dye risks breast cancer
Women who regularly use permanent hair dye could be increasing their risk of breast cancer up to 60 percent, according to scientists writing in the International Journal of Cancer. Pixabay

An intriguing finding was the association between the use of chemical hair straighteners and breast cancer.

The researchers found that women who used hair straighteners at least every five to eight weeks were about 30 per cent more likely to develop breast cancer.

While the association between straightener use and breast cancer was similar in African American and white women, straightener use was much more common among African American women, the study said.

The researchers cautioned that although there is some prior evidence to support the association with chemical straighteners, these results need to be replicated in other studies.

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When asked if women should stop dyeing or straightening their hair, study co-author Dale Sandler, “We are exposed to many things that could potentially contribute to breast cancer, and it is unlikely that any single factor explains a woman’s risk.

“While it is too early to make a firm recommendation, avoiding these chemicals might be one more thing women can do to reduce their risk of breast cancer,” Sandler said.(IANS)