Tuesday December 18, 2018

Cocaine Abuse Can be Controlled With Elevated Bile Acid Levels

The findings also contributed to a greater understanding of how gut-based signalling influenced higher order central functions such as reward

0
//
Himachal
'The traders from across the border have stopped coming' Pixabay
Republish
Reprint

Bile acids that aid in fat digestion may reduce the rewarding properties of cocaine use, suggesting potential new strategies for treatment of drug abuse, a study has found.

The findings showed that bile diversion surgery — an experimental treatment for weight loss by increasing the amount of bile acids that enter the general circulation — lowered dopamine release in response to cocaine.

Further, mice that received the surgery also had lower craving for cocaine.

“These findings redefine the physiological significance of bile acid signalling and highlighting the importance of determining whether bile acid analogues represent a viable pharmacological treatment for cocaine abuse,” said Aurelio Galli from the University of Alabama in the US.

cocaine
Representational image. Pixabay

For the study, published in the journal PLOS Biology, the team administered a drug called OCA — semi-synthetic bile acid — in mice that mimicked the effect of bile at its brain receptor named TGR5.

The results provided evidence to show that elevated levels of bile after the surgery reduced the preference for cocaine.

Also Read: How drugs like heroin, opium, cocaine, marijuana make way into India

Knocking out TGR5 from the brain’s nucleus accumbens — a central reward region — prevented bile acids from reducing cocaine’s effects, confirming that signalling through this receptor was responsible for the cocaine-related results of bile acid elevation.

The findings also contributed to a greater understanding of how gut-based signalling influenced higher order central functions such as reward. (IANS)

Click here for reuse options!
Copyright 2018 NewsGram

Next Story

Colombian drug cartels exporting cocaine underneath Valentine’s day flowers

The season before Valentine's Day is the busiest time of the year for Colombia's growers, when the 130,000 people employed at hundreds of flower farms work nonstop to ship some 500 million stems

0
Cocaine
Powder drugs. Image source-Wikimedia Commons

Cocaine is probably the last thing most people think about when buying roses. But every year, police and growers in Colombia must work around the clock to make sure that the romance of Valentine’s Day isn’t spoiled by the drug, the nation’s other major export along with flowers.

As much as 330,000 pounds (150 metric tons) of flowers leave Colombia on 30-plus jumbo cargo planes daily starting in late January, presenting an opportunity for the country’s ingenious drug cartels to penetrate the frenzied, overworked chain of suppliers and stash drugs amid the roses.

NewsGram brings to you current foreign news from all over the world.

“Without a doubt we’re a target,” said Augusto Solano, president of the Colombian flower exporters’ association.

Security protocols that the flower industry developed with police begin the moment that refrigerated trucks carrying rose buds depart dozens of flower farms dotting the waterlogged savannah surrounding Colombia’s capital. Once the flowers are inside the airport, 100 police offices equipped with 15 drug-sniffing dogs and electronic scanners inspect each shipment.

Last year, police said they found almost 200 pounds (90 kilograms) of cocaine hidden in flower boxes.

“We have to guarantee that our flower exports aren’t contaminated by criminal gangs,” Col. Julio Triana said as he and his drug-sniffing Labrador retriever walked through the refrigerated warehouse where flowers are kept before being loaded onto cargo planes.

Colombia’s flower industry took off in the early 1990s when the U.S. Congress passed a law eliminating tariffs on goods from Andean drug-producing nations in a bid to encourage legal exports. That Colombia’s criminals now train their eyes on flower shipments as a way to smuggle drugs into the U.S. is a sign of just how much the industry has blossomed. It is now is the world’s second-largest cut flower exporter, after the Netherlands, and the top supplier to the U.S.

NewsGram brings to you top news around the world today.

The season before Valentine’s Day is the busiest time of the year for Colombia’s growers, when the 130,000 people employed at hundreds of flower farms work nonstop to ship some 500 million stems, mostly to the United States but other parts of the world as well.

“Right now there’s not a single rose available,” said Solano.

But with competitors from Kenya and Ecuador making inroads, the industry isn’t taking its leadership for granted and works hard to keep out smuggled drugs.

“It requires a big effort because if another country finds drugs they can ban flower imports from Colombia and that would be disastrous,” Solano said. (VOA)